Binuclear VIV/V, MoVI and ZnII - hydroquinonate complexes: Synthesis, stability, oxidative activity and anticancer properties

Loizou, Maria; Papaphilippou, Petri; Vlasiou, Manos C.; Spilia, Maria; Peschos, Dimitrios; Simos, Yannis V.; Keramidas, Anastasios D.; Drouza, Chryssoula

doi:10.1016/j.jinorgbio.2022.111911

Cited by 3 publications

(1 citation statement)

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“…The potentiality of vanadium coordination compound in the treatment of cancer is thus-at least in part-due to the formation of DNA-hurtful ROS [50] in the physiological broth-as depicted in Equation ( 4). The intracellular formation of ROS (and thus the anti-cancer potentiality) is also activated by dinuclear complexes based on V V /Zn 2+ and V V /Mo VI [51], while mixed VO 2+ /M complexes (M = Ni 2+ , Cu 2+ , Co 3+ ) show antioxidant as well as anti-cancer activity [52].…”

Section: Medicinal Applicationsmentioning

confidence: 99%

Import and Implications of Vanadium in Live Aspects

Rehder

2023

Inorganics

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In Earth’s regions accessible for living organisms (Earth’s crust, crude oil, water sanctuaries and lower atmosphere), vanadium is present in the oxidation states +III and—essentially—+IV (cationic) and +V (cationic and anionic), with the redox interchange and biochemical recycling often monitored by bacteria. Organisms having available vanadium-containing (bio)molecules with essential functions for life include marine brown algae (haloperoxidases), ascidians and fan worms, as well as terrestrial organisms, viz., nitrogen-fixing bacteria (associated with the roots of legumes), and the fly agaric mushroom. The hypohalite generated by the algal haloperoxidases in turn is involved in the emission of bromoform into the atmosphere. Nitrogen fixation (N2 ε NH4+) is a process of immanent importance for life on our planet. Other bacterial issues include the reduction of vanadate to VO2+. Medicinal applications of vanadium coordination compounds are directed towards the treatment of diabetes mellitus (vanadium complexes with hypoglycemic activity) and cancer—although boundaries are set due to side effects such as oxidative damage elicited by vanadium-induced hyperoxide formation. Physiological actions of vanadium are often invoked due to the structural and physiological similarity between vanadate and phosphate. An additional field of medicinal applications addresses the treatment of cancer, such as leukaemia, malignant melanoma and bone cancer.

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Section: Medicinal Applicationsmentioning

confidence: 99%