Binuclear Complexes of Cu(II) and Mg(II) with 2-Furancarboxylic Acid: Synthesis, Structure, EPR Spectroscopy, and Results of In Vitro Biological Activity against Mycolicibacterium Smegmatis and SCOV3

Abstract

Using the reactions of copper(II) acetate magnesium(II) oxide with 2-furancarboxylic acid (HFur), compounds with chemical compositions [Cu 2 (Fur) 4 (MeCN) 2 ] (I) and [Mg 2 (Fur) According to the X-ray diffraction data (CIF files CCDC nos. 2085817 (I) and 2085818 (II)), both complexes have a binuclear structure. The metal core of I correspond to the tetracarboxylate bridged {Cu 2 (μ-Fur) 4 } complex, the coordination number of the copper atom in which is 5 (CuNO 4 ); in II, the metal atoms are linked by two carboxylate groups and a water molecule, and the coordination environment of the metal centers is completed to the polyhedron (MgO 6 ) by oxygen atoms of the Furanions and water molecules. According to EPR spectroscopy data, exchange-coupled copper(II) dimers with a substantial zero-field splitting are observed in I. For I and II, antibacterial activity against the nonpathogenic strain of M. smegmatis, and cytotoxicity against human ovarian adenocarcinoma cells SCOV3 and normal human fibroblast cells of the HDF line have been determined.

Highly selective cross ketonization of renewable acids over magnesium oxide

“…6d). 24,40 This deactivation was observed by Huang et al where 2-furoic acid produced in situ through the Cannizzaro reaction blocked the active sites of the calcium catalyst by forming metal carboxylates. 41 Despite deactivation through the 2-furoic acid complex formation and carbonate deposition, the spent catalyst was successfully recycled for four runs via regeneration by calcination in air, as shown in Fig.…”

Cu(ii) 3,5-diiodosalicylate complexes: precursor-dependent formation of mono-, di-, tri- and tetranuclear compounds and 1D coordination polymers

“…4 belongs to a very widespread family of paddlewheel-type complexes: the [Cu 2 (carboxylate) 4 L 2 ] family. [46][47][48][49] Four HDISA units (Cu-O = 1.966 Å) connect two Cu atoms into a binuclear core (Cu⋯Cu = 2.668 Å). The -OH groups of HDISA are disordered over two positions with equal occupancies.…”

Solvent effect in the chemical design of coordination polymers of various topologies with Co2+ and Ni2+ ions and 2-furoate anions

“…13,26,30 The complexes of 3d-metals with 2-furoic acid (Hfur) studied previously showed bioactivity against mycobacterial strains, along with interesting magnetic and sorption properties. [32][33][34][35][36][37][38][39][40][41] In this work, we focused on the study of the self-assembly of 1-, 2-and 3-D coordination polymers by slow diffusion of a crosslinking ligand solution (1,2-bis(4-pyridyl)ethylene) into solutions of Ni II /Co II furoates in various solvents. Given the apparent simplicity of the suggested approach (no special conditions), it was observed that varying the solvents allowed polymers with various dimensions and structures to be formed.…”

“…13,26,30 The complexes of 3d-metals with 2-furoic acid (Hfur) studied previously showed bioactivity against mycobacterial strains, along with interesting magnetic and sorption properties. 32–41…”