Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior

Nikolić, Mirjana Antonijević; Szécsényi, Katalin Mészáros; Dražić, Branka; Rodić, Marko V.; Stanić, Vojislav; Tanasković, Slađana

doi:10.1016/j.molstruc.2021.130133

Cited by 8 publications

(3 citation statements)

References 54 publications

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“…In vitro cytotoxic evaluation, formation constants, and thermal stability of four mixed-ligand Co(II) complexes with N , N ′, N ″, N ‴-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane were reported by Nicolic and coauthors. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and EGA-MS measurements [ 29 ]. Studies over several years on imidazole derivative ligands suggested two main characteristic complex structures that are independent of the central metal ion.…”

Section: Applications To Complexes and Compoundsmentioning

confidence: 99%

On-Line Thermally Induced Evolved Gas Analysis: An Update—Part 1: EGA-MS

et al. 2022

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Advances in on-line thermally induced evolved gas analysis (OLTI-EGA) have been systematically reported by our group to update their applications in several different fields and to provide useful starting references. The importance of an accurate interpretation of the thermally-induced reaction mechanism which involves the formation of gaseous species is necessary to obtain the characterization of the evolved products. In this review, applications of Evolved Gas Analysis (EGA) performed by on-line coupling heating devices to mass spectrometry (EGA-MS), are reported. Reported references clearly demonstrate that the characterization of the nature of volatile products released by a substance subjected to a controlled temperature program allows us to prove a supposed reaction or composition, either under isothermal or under heating conditions. Selected 2019, 2020, and 2021 references are collected and briefly described in this review.

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Section: Applications To Complexes and Compoundsmentioning

confidence: 99%

On-Line Thermally Induced Evolved Gas Analysis: An Update—Part 1: EGA-MS

et al. 2022

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“…The current approach of advanced bioinorganic chemistry consists of using simple well-known biologically active molecules to design effective metallodrugs. Such ligands include, for example, benzimidazole derivatives [ 1 , 2 ]; purine bases [ 3 , 4 ], particularly caffeine [ 5 , 6 , 7 , 8 , 9 ]; the well-known commercially available ligand 1,10-phenanthroline [ 10 ]; anions of biologically active carboxylic acids (benzoic [ 11 , 12 ], 2-furoic [ 13 , 14 ], etc. ); dithiocarbamates [ 15 , 16 ]; and redox-active ligands [ 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol

Yambulatov,

Lutsenko,

Baravikov

et al. 2023

Molecules

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A new silver(I) cluster [Ag8L4(Py)(Pype)]·4Py·11H2O (I) with 3-benzyl-4-phenyl-1,2,4-triazol-5-thiol (L) was synthesized via the direct reaction of AgNO3 and L in MeOH, followed by recrystallization from a pyridine–piperidine mixture. The compound I was isolated in a monocrystal form and its crystal structure was determined via single crystal X-ray diffraction. The complex forms a “butterfly” cluster with triazol-5-thioles. The purity of the silver complex and its stability in the solution was confirmed via NMR analysis. Excitation and emission of the free ligand and its silver complex were studied at room temperature for solid samples. The in vitro biological activity of the free ligand and its complex was studied in relation to the non-pathogenic Mycolicibacterium smegmatis strain. Complexation of the free ligand with silver increases the biological activity of the former by almost twenty times. For the newly obtained silver cluster, a bactericidal effect was established.

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“…Cobalt(II) macrocyclic complexes possess significant antibacterial and antifungal as compared to other transition metal complexes. 24 Here in the presented work, the macrocyclic ligands were synthesized by condensation of o-phenylenediamine with substituted pyridine and phthalic acid, and their coordination behaviour with cobalt(II) compounds was studied (Scheme 1 ). Numerous spectral analyses, including elemental analysis, FT-IR, 1 H NMR, 13 C NMR, mass spectrometry, UV-vis, SEM analysis, X-ray diffraction, DFT, and TG analysis, were used to explain the structure of these ligands and their complexes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic Characterization, Biocidal evaluation Molecular Docking & DFT Investigation of 16-18 membered Macrocyclic Complexes of Cobalt (II)

et al. 2022

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Macrocyclic ligands (MacL 1 -MacL 3 ) and Co(II) complexes were synthesized via template condensation of o-phenylenediamine with various aromatic dicarboxylic acids. The elemental analysis, FT-IR, mass spectrometry, 1 H NMR, 13 C NMR, UV-vis, SEM analysis, powder X-ray diffraction, thermogravimetric (TG) analysis, electrochemical studies, and DFT analysis were used to characterize these synthesized ligands and their cobalt (II) complexes. TGA analysis to determine the stability and decomposition kinetic parameters. In element analysis, the percentage of different elements present and also the stoichiometry of compounds were confirmed. The proposed framework for tetraaza macrocyclic cobalt (II) complexes was supported by spectral analysis, which also revealed distorted octahedral geometry surrounding the central metal atom. The molecular structure of cobalt (II) complexes was also optimized theoretically, and their electronic or thermodynamic parameters were obtained from density functional theory (DFT). The synthesized ligands and their cobalt (II) complexes were tested against bacteria: Escherichia coli, Bacillus subtitles. Candida albicans were tested for antifungal properties. It was found that ligands and complexes show good antimicrobial results. Finally, using the Auto Dock VinaPyRx programme, molecular docking studies were used to evaluate the biological significance of the synthesized ligands to identify the probable and efficient binding mechanisms between the various ligands and the active site of the receptor protein. Graphical abstract Antimicrobial, DFT, and Docking representation of Cobalt (II) macrocyclic complexes Supplementary Information The online version contains supplementary material available at 10.1007/s12039-022-02109-2.

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Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior

Cited by 8 publications

References 54 publications

On-Line Thermally Induced Evolved Gas Analysis: An Update—Part 1: EGA-MS

On-Line Thermally Induced Evolved Gas Analysis: An Update—Part 1: EGA-MS

Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol

Synthesis, Spectroscopic Characterization, Biocidal evaluation Molecular Docking & DFT Investigation of 16-18 membered Macrocyclic Complexes of Cobalt (II)

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