Binocular, Accommodative and Oculomotor Alterations In Multiple Sclerosis: A Review

Gil-Casas, Amparo; Piñero, David P.; Molina‐Martín, Ainhoa

doi:10.1080/08820538.2020.1744671

Cited by 9 publications

(3 citation statements)

References 129 publications

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“…These changes are distributed unevenly across the retina meaning that multifocal functional measures such as mfPOP are ideally suited to quantifying them. Studying the pupils may offer an additional advantage given that the whole accommodative triad has recently been shown to be affected by MS [ 25 ]. Despite a relatively small cohort, this study was able to obtain significant results but a larger, prospective study using the novel techniques with a similar duration of follow-up is clearly warranted.…”

Section: Discussionmentioning

confidence: 99%

Objective perimetry and progression of multiple sclerosis

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Objective perimetry and progression of multiple sclerosis

et al. 2022

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“…Ocular motor dysfunction is present in almost 90–95% of the patients with multiple sclerosis (MS) due to the demyelination in the visual pathway [ 1 , 2 ]. Demyelinating lesions in the posterior fossa are a frequent cause of ocular motor dysfunction [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Developmental Eye Movement (DEM) and King-Devick (K-D) Performance in Multiple Sclerosis

2022

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Eye movement disorders have been reported in patients with multiple sclerosis (MS) as saccadic disturbances. Several methods have been described for the assessment of saccades, including the K-D and DEM tests. The performance of these tests also involves attention, language, and other brain areas which have been reported to be altered in MS patients. The aim of the study was to determine how developmental eye movement (DEM) and King-Devick (K-D) tests are affected in MS-patients. It was also to analyze whether a resolved episode of optic neuritis (ON) has a negative influence. Subjects with MS showed worse outcomes (higher times) in DEM test (72 (26) s and a K-D test (56 (22) s compared to healthy subjects (64 (7) s and 55 (11) s, respectively). However, a previous ON episode did not worsen the MS-times of DEM (80 (33) s or of K-D (62 (33) s. Horizontal saccades with the DEM showed differences between subjects with MS (with and without ON) and healthy ones (p < 0.05), whereas no such differences were found in the vertical saccades. According to the DEM instructions, MS patients would present heterogeneous oculomotor and non-visual disturbances. Regarding the K-D test, only the third card (the most complex one) showed differences (p < 0.05) between groups. These tests can capture impairment of attention, language, and other areas that correlate with suboptimal brain function in addition to the oculomotor dysfunctions present in subjects with MS.

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“…Several studies have demonstrated that oculomotricity can be limited or altered in different health conditions, including neurological [ 9 ] or neurodevelopmental disorders (NDD), such as dyslexia, attention deficit disorder (ADHD) or developmental coordination disorder (DCD) [ 10 ]. In general, problems of ability and precision of saccades have been detected in these three NDDs, with movements of body and head associated [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Objective and Subjective Evaluation of Saccadic Eye Movements in Healthy Children and Children with Neurodevelopmental Disorders: A Pilot Study

Bilbao

Piñero

2021

Vision

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The objective of this study was to characterize saccades in children with neurodevelopmental disorders (NDDG, 17 children, age: 7–12 years) and compare them with a control group (CG, 15 children, age: 7–12 years), comparing the outcomes obtained with a subjective score system (Northeastern State University College of Optometry’s Oculomotor test, NSUCO) with the objective analysis obtained through a commercially available Eye Tracker (Tobii Eye X, Tobii, Stockholm, Sweden) and a specialized software analysis (Thomson Software Solutions, Welham Green, UK). Children from the NDDG obtained significantly lower NSUCO scores (p < 0.001) compared with CG. Concerning eye tracking analyses, we found a significantly higher number of hypometric saccades in NDGG (p ≤ 0.044). Likewise, we found a significantly higher percentage of regressions in the NDDG for a time interval of presentation of stimuli of 1 s (p = 0.012). Significant correlations were found between different NSUCO scores and percentage of regressions, number of saccades completed and number of hypometric saccades. The presence of hypometric saccades and regressions seems to be a differential characteristic sign of children with neurodevelopmental disorders that can be detected using an objective eye tracking analysis, but also using the subjective test NSUCO that can be easily implemented in all clinical settings.

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Binocular, Accommodative and Oculomotor Alterations In Multiple Sclerosis: A Review

Cited by 9 publications

References 129 publications

Objective perimetry and progression of multiple sclerosis

Objective perimetry and progression of multiple sclerosis

Developmental Eye Movement (DEM) and King-Devick (K-D) Performance in Multiple Sclerosis

Objective and Subjective Evaluation of Saccadic Eye Movements in Healthy Children and Children with Neurodevelopmental Disorders: A Pilot Study

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