Binge-pattern cocaine administration causes long-lasting behavioral hyperarousal but does not enhance vulnerability to single prolonged stress in rats

Lisieski, Michael J.; Perrine, Shane A.

doi:10.1016/j.psychres.2017.07.026

Cited by 9 publications

(7 citation statements)

References 49 publications

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“…This study confirmed our previous findings (Lisieski & Perrine, 2017) that repeated cocaine exposure followed by an extended drug-free period caused a disinhibited, hyperexploratory phenotype in the OF and EPM tests. As in our previous study, cocaine exposure increased locomotor activity in the OF and open arm exploration in the EPM.…”

Section: Discussionsupporting

confidence: 92%

“…Although there were no group‐wise effects of previous cocaine exposure on LC c‐fos expression or NE concentrations in this study, novelty exposure significantly increased NE in the ACC, and increased exploration of anxiogenic areas of the EPM was correlated with LC c‐fos expression and NE in the ACC and NAC. This pattern of associations suggests that changes in NE function may be related to disinhibited exploratory phenotypes such as those generated by repeated stimulant administration (Lisieski & Perrine, ; Mantsch et al, ; Olausson et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Values in which significant effects were seen are bolded. (Lisieski & Perrine, 2017;Mantsch et al, 2008;Olausson et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, we observed that rats treated with binge‐pattern cocaine followed by an extended drug‐free period exhibited a disinhibited, hyperexploratory phenotype (Lisieski & Perrine, ). Similar observations have been made by other investigators following cocaine self‐administration (Mantsch et al, ) and amphetamine injections (Olausson, Engel, & Söderpalm, ).…”

Section: Introductionmentioning

confidence: 97%

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Divergent effects of repeated cocaine and novel environment exposure on locus coeruleus c‐fos expression and brain catecholamine concentrations in rats

et al. 2019

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Introduction Chronic administration of cocaine causes a disinhibited, hyperexploratory response to novel environments. As the norepinephrine (NE) system regulates exploration and is dysregulated following cocaine exposure, we hypothesized that this cocaine‐mediated hyperexploratory response is associated with increased locus coeruleus (LC) reactivity. Methods To test this hypothesis, we used dual fluorescent in situ hybridization immunofluorescence to analyze novelty‐induced c‐fos and tyrosine hydroxylase expression in the LC and high‐pressure liquid chromatography to measure dopamine (DA) and NE concentrations in key catecholamine projection regions following exposure to cocaine. Results Repeated cocaine exposure followed by a 14‐day drug‐free period increased exploration of novel environments, replicating previous findings. Novelty exposure increased LC c‐fos expression, increased anterior cingulate NE, and decreased ventral tegmental area DA. Cocaine exposure decreased amygdala (AMY) DA, but had no effect on LC c‐fos expression or NE in any tested brain region. No interactions between cocaine and novelty were found. Open arm exploration was positively correlated with LC c‐fos expression and NE concentrations in both the anterior cingulate and nucleus accumbens, and negatively correlated with AMY DA concentration. Conclusions Our findings confirm that exposure to novel environments increases LC activity and NE in the anterior cingulate cortex, that long‐term exposure to cocaine dysregulates AMY DA, and that disinhibited exploration in novel environments correlates with NE and DA in regions that modulate risk‐taking and avoidance behavior. Further studies investigating the effects of cocaine on brain catecholamine systems are important in understanding the long‐lasting effects of cocaine on brain function.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

“…Values in which significant effects were seen are bolded. (Lisieski & Perrine, 2017;Mantsch et al, 2008;Olausson et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Divergent effects of repeated cocaine and novel environment exposure on locus coeruleus c‐fos expression and brain catecholamine concentrations in rats

et al. 2019

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“…Water level was maintained at 2 cm above the platform's surface [15] . There were many prominent visual cues that remained constantly positioned around the testing room throughout the study, to serve as distal spatial cues to the location of the platform [16] .No local cues were present within the pool.A stopwatch was used to measure latency to reach the platform during acquisition trials [17] . A video camera was mounted on the ceiling to record the rats' swim patterns during the probe trials and individuals blinded to group assignment scored the videos to obtain the retention data [18] .…”

Section: Water Mazementioning

confidence: 99%

Changes of Learning and Memory Ability in fos-GFP Transgenic Mice

W¹,

Cao²,

XiaoM³

2019

ijSciences

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Objective To study the changes of learning and memory ability in fos-GFP transgenic mice. Methods The mice in the fos-GFP group and the control were tested by using overhead cross maze,open field,and Morris Water Maze [1]. The spontaneous activity,anxiety state,the ability of learning and memory were tested as well. Results The differences between fos-GFP mice and the control were not significant in terms of distance of motion within the field,velocity,duration of stay at the marginal zone,and duration of open arm in the maze(p>0.05).The difference between the mice in the two groups was not significant with regard to latency of finding the flat at each time point(p>0.05),and the percentage of duration in target quadrant in Morris Water Maze(p>0.05),and similar freezing time in contextual fear conditioning test(p>0.05).The fos-GFP mice showed higher freezing level than normal controls in no-exposed fear conditioning(t=9.48,P<0.001). Conclusion The ability of hippocampus-dependent associative learning and memory in fos-GFP transgenic mice was somewhat improved.

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Repeated cocaine exposure prior to fear conditioning induces persistency of PTSD-like symptoms and enhancement of hippocampal and amygdala cell density in male rats

et al. 2021

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Repeated cocaine exposure prior to fear conditioning induces persistency of PTSD-like symptoms and enhancement of hippocampal and amygdala cell density in male rats --Manuscript Draft--Manuscript Number: BSAF-D-21-00049R1Full Title: Repeated cocaine exposure prior to fear conditioning induces persistency of PTSD-like symptoms and enhancement of hippocampal and amygdala cell density in male rats Article Type:

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Binge-pattern cocaine administration causes long-lasting behavioral hyperarousal but does not enhance vulnerability to single prolonged stress in rats

Cited by 9 publications

References 49 publications

Divergent effects of repeated cocaine and novel environment exposure on locus coeruleus c‐fos expression and brain catecholamine concentrations in rats

Divergent effects of repeated cocaine and novel environment exposure on locus coeruleus c‐fos expression and brain catecholamine concentrations in rats

Changes of Learning and Memory Ability in fos-GFP Transgenic Mice

Repeated cocaine exposure prior to fear conditioning induces persistency of PTSD-like symptoms and enhancement of hippocampal and amygdala cell density in male rats

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