Binge-like palatable food intake in rats reduces preproglucagon in the nucleus tractus solitarius

Mukherjee, Ashmita; Hum, Avery; Gustafson, Tyler J.; Mietlicki‐Baase, Elizabeth G.

doi:10.1016/j.physbeh.2020.112830

Cited by 4 publications

(2 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, intermittent access to a high‐fat diet reduced PPG mRNA levels in the NTS of male rats, suggesting lower levels of centrally released GLP1. Still, these rats increased plasma GLP1 before food administration, which may indicate an anticipatory food response compared to rats with daily access to the same diet (Mukherjee et al ., 2020; Vahl et al ., 2010; Dailey et al ., 2012). This effect has not been reproduced in female rats (Mukherjee, DiBrog & Mietlicki‐Baase, 2022), suggesting sexual dimorphism in the GLP1 regulation of feeding behaviour.…”

Section: Exploring the Roles Of Leptin Glucocorticoids And Glp1 In Ea...mentioning

confidence: 99%

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

Perez‐Leighton,

Kerr,

Scherer

et al. 2023

Biological Reviews

View full text Add to dashboard Cite

Nutritional, endocrine, and neurological signals converge in multiple brain centres to control feeding behaviour and food intake as part of the allostatic regulation of energy balance. Among the several neuroendocrine systems involved, the leptin, glucocorticoid, and glucagon‐like peptide 1 (GLP1) systems have been extensively researched. Leptin is at the top hierarchical level since its complete absence is sufficient to trigger severe hyperphagia. Glucocorticoids are key regulators of the energy balance adaptation to stress and their sustained excess leads to excessive adiposity and metabolic perturbations. GLP1 participates in metabolic adaptation to food intake, regulating insulin secretion and satiety by parallel central and peripheral signalling systems. Herein, we review the brain and peripheral targets of these three hormone systems that integrate to regulate food intake, feeding behaviour, and metabolic homeostasis. We examine the functional relationships between leptin, glucocorticoids, and GLP1 at the central and peripheral levels, including the cross‐regulation of their circulating levels and their cooperative or antagonistic actions at different brain centres. The pathophysiological roles of these neuroendocrine systems in dysregulated intake are explored in the two extremes of body adiposity – obesity and lipodystrophy – and eating behaviour disorders.

show abstract

Section: Exploring the Roles Of Leptin Glucocorticoids And Glp1 In Ea...mentioning

confidence: 99%

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

Perez‐Leighton,

Kerr,

Scherer

et al. 2023

Biological Reviews

View full text Add to dashboard Cite

show abstract

“…The loss of control and overeating results in compulsive eating behavior, certain forms of obesity, and the recently proposed term of "food addiction" [264]. Recently, it has been demonstrated that binge-like eating over several weeks in a model of intermittent fat feeding in rats affects the GLP-1 system, decreasing PPG mRNA expression in the NTS, suggesting downregulation of central GLP-1 signaling [265], accordingly with dysfunction in satiation processes that generally serve to limit food intake observed in different animal models [265]. Moreover, rats with intermittent access to a high-fat diet show large meals [266] and reduced responsiveness to intragastric nutrients and amylin, supporting the idea of reduced sensitivity to satiation signals under these conditions [266].…”

Section: Stress In Obesity: Glp-1 and The Motivation To Feedmentioning

confidence: 99%

Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress

et al. 2020

View full text Add to dashboard Cite

Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding, and the motivation to feed or regulate the stress response and the hypothalamic-pituitary-adrenal axis. GLP-1 receptor (GLP-1R) controls both food intake and feeding behavior (hunger-driven feeding, the hedonic value of food, and food motivation). The activation of GLP-1 receptors involves second messenger pathways and ionic events in the autonomic nervous system, which are very relevant to explain the essential central actions of GLP-1 as neuromodulator coordinating food intake in response to a physiological and stress-related stimulus to maintain homeostasis. Alterations in GLP-1 signaling associated with obesity or chronic stress induce the dysregulation of eating behavior. This review summarized the experimental shreds of evidence from studies using GLP-1R agonists to describe the neural and endocrine integration of stress responses and feeding behavior.

show abstract

Macronutrient intake: Hormonal controls, pathological states, and methodological considerations

Przybysz

DiBrog²,

Kern³

et al. 2023

Appetite

View full text Add to dashboard Cite

Binge-like palatable food intake in rats reduces preproglucagon in the nucleus tractus solitarius

Cited by 4 publications

References 70 publications

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress

Macronutrient intake: Hormonal controls, pathological states, and methodological considerations

Contact Info

Product

Resources

About