Binge Ethanol Consumption Causes Differential Brain Damage in Young Adolescent Rats Compared With Adult Rats

Crews, Fulton T.; Braun, Christopher J.; Hoplight, Blair J.; Switzer, Robert C.; Knapp, Darin J.

doi:10.1111/j.1530-0277.2000.tb01973.x

Cited by 440 publications

(273 citation statements)

References 56 publications

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“…It would be interesting for future studies to investigate in longitudinal studies if an alcohol-specific impairment of response inhibition changes over the course of time when drinking patterns are changing and problem drinking develops. At present, we only know that impulsive behavior and an impairment of response inhibition are risk factors for the development of problem drinking and addictive behavior [22], and it is assumed that this association is reciprocal as chronic alcohol consumption further impairs cognitive control processes [37]. …”

Section: Discussionmentioning

confidence: 99%

Is Binge Drinking in Young Adults Associated with an Alcohol-Specific Impairment of Response Inhibition?

Czapla

Simon²,

Friederich³

et al. 2014

Eur Addict Res

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Background/Aims: Little is known about the association of binge drinking with impulsivity related to trait- or state-like aspects of behavior. The aim of the present study was therefore to investigate whether binge drinkers show an impairment of inhibitory control in comparison to non-binge drinkers when confronted with alcohol-associated or control stimuli, and whether this is reflected in self-reported impulsivity. Methods: A go/no-go task with pictures of alcoholic and nonalcoholic beverages as well as control stimuli was administered to binge drinkers and a gender-matched group of non-binge drinkers. All participants also completed the Barratt Impulsiveness Scale (BIS-11). Results: We found an alcohol-specific impairment of response inhibition for binge drinkers only, while the groups did not differ with regard to overall response inhibition to the experimental stimuli or self-reported impulsiveness (BIS-11). In addition, the number of commission errors in response to alcohol-associated stimuli was the only significant predictor of binge drinking. Conclusion: The findings of the present study suggest that when young adults have established binge drinking as a common drinking pattern, impairment of inhibition in response to alcoholic stimuli is the only significant predictor of binge drinking, but not general impulsive behavior. i 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Is Binge Drinking in Young Adults Associated with an Alcohol-Specific Impairment of Response Inhibition?

Czapla

Simon²,

Friederich³

et al. 2014

Eur Addict Res

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“…Heavy alcohol consumption within a short period of time (i.e., binge drinking) may be particularly detrimental for college-aged students because motivational neurocircuitry underlying risk, reward and decision-making continues to develop during this period (Crews, et al, 2000; Chambers et al, 2003; Monti, et al, 2005). Consistent with this idea, binge ethanol consumption during adolescence in animals is associated with damage of frontal brain areas (Crews et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Binge drinking in undergraduates: relationships with sex, drinking behaviors, impulsivity, and the perceived effects of alcohol

Balodis¹,

Potenza²,

Olmstead

2009

Behavioural Pharmacology

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Binge drinking on university campuses is associated with social and health-related problems. In order to determine the factors that may predict this behavior, we collected information on alcohol use, alcohol expectations, and impulsivity from 428 undergraduate students attending a Canadian university. The subjective effects of a binge-drinking dose of alcohol were assessed in a subset of participants. In the larger sample, 72% of students reported drinking at or above binge drinking thresholds on a regular basis. Men reported alcohol consumption per drinking occasion that was consistent with other studies, but the frequency of drinking occasions among women was higher than previous studies, suggesting that consumption in women may be increasing. Compared to men, women reported different expectations of alcohol, specifically related to sociability and sexuality. Self-reported impulsivity scores were related, albeit weakly, to drinking behaviors and to expectations in both sexes. Finally, intoxicated binge drinkers reported feeling less intoxicated, liking the effects more and wanting more alcohol than did non-binge drinkers receiving an equivalent dose of alcohol. These results have implications for gender-specific prevention strategies for binge drinking on university campuses

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“…Some authors have demonstrated that ethanol leads to neuronal loss in different brain regions and neuronal loss seems to be associated with cognitive impairment and dementia, neurotransmitter deficiency and mental health issues (Brooks 1997;Brooks 2000;Harper and Matsumoto 2005). Binge ethanol consumption in adult rats leads to neuronal damage in the entorhinal and perirhinal cortices, while in juvenile animals, there also is a marked damage to frontal paleocortical regions (Crews et al 2000).…”

Section: Discussionmentioning

confidence: 98%

Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats

et al. 2015

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Binge Ethanol Consumption Causes Differential Brain Damage in Young Adolescent Rats Compared With Adult Rats

Abstract: The young-adolescent brain shows differential sensitivity to alcohol-induced brain damage compared with adults.

Cited by 440 publications

References 56 publications

Is Binge Drinking in Young Adults Associated with an Alcohol-Specific Impairment of Response Inhibition?

Is Binge Drinking in Young Adults Associated with an Alcohol-Specific Impairment of Response Inhibition?

Binge drinking in undergraduates: relationships with sex, drinking behaviors, impulsivity, and the perceived effects of alcohol

Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats

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