Binge eating, depressive symptoms and suicidal ideation in obese candidates for bariatric surgery

Aguiar, Priscilla Vasconcelos; Dionísio, Weslley Alex da Silva; Souza, Ester Alana da Costa; Vantini, Davi; Campanholi, Raphael; Pinto, Tiago Coimbra Costa; Ximenes, Rosana Christine Cavalcanti

doi:10.1007/s40519-023-01533-8

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…There is evidence to support that obesity and eating disorders are related to psychiatric comorbidities [15][16][17][18][19][20][21][22][23][24]. Among Brazilian obese patients, binge eating disorders were found to correlate with depression and suicidal thoughts [25]. Additionally, patients seeking bariatric weight loss surgery often suffer from various affective and psychological disorders including anxiety, depression, and body image dissatisfaction [26].…”

Section: Introductionmentioning

confidence: 99%

Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year

Thanos,

Hanna,

Mihalkovic

et al. 2023

Biomedicines

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This study analyzed genetic risk assessments in patients undergoing bariatric surgery to serve as a predictive factor for weight loss parameters 1 year after the operation. Thirty (30) patients were assessed for Genetic Addiction Risk Severity (GARS), which analyzes neurogenetic polymorphisms involved in addiction and reward deficiency. Genetic and psychosocial data collected before the operation were correlated with weight loss data, including changes in weight, body mass index (BMI), and percent of expected weight loss (%EWL). Results examined correlations between individual gene risk alleles, 1-year body weight data, and psychosocial trait scores. Spearman’s correlations revealed that the OPRM1 (rs1799971) gene polymorphism had significant negative correlation with 1-year weight (rs = −0.4477, p < 0.01) and BMI (rs = −0.4477, p < 0.05). In addition, the DRD2 risk allele (rs1800497) was correlated negatively with BMI at 1 year (rs = −0.4927, p < 0.05), indicating that one risk allele copy was associated with lower BMI. However, this allele was positively correlated with both ∆Weight (rs = 0.4077, p < 0.05) and %EWL (rs = 0.5521, p < 0.05) at 1 year post-surgery. Moreover, the overall GARS score was correlated with %EWL (rs = 0.4236, p < 0.05), ∆Weight (rs = 0.3971, p < 0.05) and ∆BMI (rs = 0.3778, p < 0.05). Lastly, Food Cravings Questionnaire (FCQ) scores were negatively correlated with %EWL (rs = −0.4320, p < 0.05) and ∆Weight at 1 year post-surgery (rs = −0.4294, p < 0.05). This suggests that individuals with a higher genetic addiction risk are more responsive to weight loss treatment, especially in the case of the DRD2 polymorphism. These results should translate clinically to improve positivity and attitude related to weight management by those individuals born with the risk alleles (rs1800497; rs1799971).

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Section: Introductionmentioning

confidence: 99%

Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year

Thanos,

Hanna,

Mihalkovic

et al. 2023

Biomedicines

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“…The higher the degree of obesity, the greater the risk of developing complex comorbidities [ 1 ]. Specially, obesity is related with increased risk of accelerated cognitive decline and emotional distress [ 3 , 4 ], suggesting neurobiological changes.…”

Section: Introductionmentioning

confidence: 99%

White Matter Integrity Abnormalities in Healthy Overweight Individuals Revealed by Whole Brain Meta-Analysis of Diffusion Tensor Imaging Studies

Cheng,

Wang,

Sun

et al. 2023

Journal of Obesity

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Objective. This study aimed to conduct a coordinate-based meta-analysis (CBMA) to investigate white matter (WM) abnormalities in healthy individuals with overweight or obesity. Methods. A systematic literature search using Web of Science and PubMed datasets was performed. Original investigations that used diffusion tensor imaging (DTI) to explore fractional anisotropy (FA) differences between healthy overweight/obese individuals and normal weight controls were collected. The meta-analysis was conducted using the seed-based d mapping (SDM) software, employing stringent thresholds for significance. Sensitivity analyses and meta-regression analysis were also performed to examine the robustness of the results and explore potential associations with age and body mass index (BMI). Results. The analysis included five studies comprising 232 overweight/obese individuals and 219 healthy normal weight controls. The findings showed that overweight/obese individuals exhibited reduced fractional anisotropy (FA) in specific regions, namely, the right superior longitudinal fasciculus (SLF), the splenium of the corpus callosum (CC), and the right median network, cingulum. Meta-regression analysis further revealed that these FA reductions were associated with age. Conclusion. These findings provided insights into the potential impact of overweight/obesity on cognition, emotion, and neural functions and highlighted the significance of early prevention and intervention for overweight on the basis of neuroimaging.

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Adipositaschirurgie (Bariatrische Chirurgie)

Kapfhammer

2023

Depression, Angst Und Traumatischer Stress in Der Chirurgie

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Binge eating, depressive symptoms and suicidal ideation in obese candidates for bariatric surgery

Cited by 3 publications

References 53 publications

Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year

Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year

White Matter Integrity Abnormalities in Healthy Overweight Individuals Revealed by Whole Brain Meta-Analysis of Diffusion Tensor Imaging Studies

Adipositaschirurgie (Bariatrische Chirurgie)

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