Binge drinking impacts dorsal striatal response during decision making in adolescents

Jones, Scott A.; Cservenka, Anita; Nagel, Bonnie J.

doi:10.1016/j.neuroimage.2016.01.044

Cited by 38 publications

(39 citation statements)

References 66 publications

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“…Dopamine release in the NAcc was not altered by BD; however, we found reduced DA release in rats categorized as PDM compared with those categorized as GDMs, consistent with previous studies (de Visser et al . ; Rogers ; Jones, Cservenka, & Nagel ). The absence of a significant difference between our control and BD groups could be due to one of three possible factors.…”

Section: Discussionmentioning

confidence: 99%

Face validity of a pre‐clinical model of operant binge drinking: just a question of speed

et al. 2018

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Binge drinking (BD) is often defined as a large amount of alcohol consumed in a 'short' period of time or 'per occasion'. In clinical research, few researchers have included the notion of 'speed of drinking' in the definition of BD. Here, we aimed to describe a novel pre-clinical model based on voluntary operant BD, which included both the quantity of alcohol and the rapidity of consumption. In adult Long-Evans male rats, we induced BD by regularly decreasing the duration of ethanol self-administration from 1-hour to 15-minute sessions. We compared the behavioral consequences of BD with the behaviors of rats subjected to moderate drinking or heavy drinking (HD). We found that, despite high ethanol consumption levels (1.2 g/kg/15 minutes), the total amounts consumed were insufficient to differentiate HD from BD. However, consumption speed could distinguish between these groups. The motivation to consume was higher in BD than in HD rats. After BD, we observed alterations in locomotor coordination in rats that consumed greater than 0.8 g/kg, which was rarely observed in HD rats. Finally, chronic BD led to worse performance in a decision-making task, and as expected, we observed a lower stimulated dopaminergic release within nucleus accumbens slices in poor decision makers. Our BD model exhibited good face validity and can now provide animals voluntarily consuming very rapidly enough alcohol to achieve intoxication levels and thus allowing the study of the complex interaction between individual and environmental factors underlying BD behavior.

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Section: Discussionmentioning

confidence: 99%

Face validity of a pre‐clinical model of operant binge drinking: just a question of speed

et al. 2018

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“…Only the feedback phase (combining wins across all types of trials) was analyzed in the present study, because it offers the most power for statistical analysis (i.e. number of trials is not limited by participant selections) (Jones, Cservenka, & Nagel, 2016; Steele et al, 2016). During this phase, the screen indicated whether the participant won or did not win money during that trial, as well as the cumulative dollar amount won up to that point.…”

Section: Methodsmentioning

confidence: 99%

“…One-sample t -tests of task activation were thresholded at a voxel level of p < 0.001, uncorrected, summed and binarized to create a task-relevant mask (33,903 total voxels). By using this approach, we limit the detection of findings to those pertinent to the task conditions, as previously published (Cservenka et al, 2012; Cservenka, Jones, & Nagel, 2015; Jones et al, 2016). Sex differences were then examined within this reward-related activity mask.…”

Section: Methodsmentioning

confidence: 99%

Adolescent neural response to reward is related to participant sex and task motivation

Alarcón

Cservenka

Nagel

2017

Brain and Cognition

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Risky decision making is prominent during adolescence, perhaps contributed to by heightened sensation seeking and ongoing maturation of reward and dopamine systems in the brain, which are, in part, modulated by sex hormones. In this study, we examined sex differences in the neural substrates of reward sensitivity during a risky decision-making task and hypothesized that compared with girls, boys would show heightened brain activation in reward-relevant regions, particularly the nucleus accumbens, during reward receipt. Further, we hypothesized that testosterone and estradiol levels would mediate this sex difference. Moreover, we predicted boys would make more risky choices on the task. While boys showed increased nucleus accumbens blood oxygen level-dependent (BOLD) response relative to girls, sex hormones did not mediate this effect. As predicted, boys made a higher percentage of risky decisions during the task. Interestingly, boys also self-reported more motivation to perform well and earn money on the task, while girls self-reported higher state anxiety prior to the scan session. Motivation to earn money partially mediated the effect of sex on nucleus accumbens activity during reward. Previous research shows that increased motivation and salience of reinforcers is linked with more robust striatal BOLD response, therefore psychosocial factors, in addition to sex, may play an important role in reward sensitivity. Elucidating neurobiological mechanisms that support adolescent sex differences in risky decision making has important implications for understanding individual differences that lead to advantageous and adverse behaviors that affect health outcomes.

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“…This criterion is in accordance with NIAAA guidelines of binge drinking (32) and has been utilized previously by our lab (33, 34). …”

Section: Methodsmentioning

confidence: 99%

Binge drinking and family history of alcoholism are associated with an altered developmental trajectory of impulsive choice across adolescence

2017

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Aims To test whether binge drinking, the density of familial alcoholism (FHD), and their interaction are associated with an altered developmental trajectory of impulsive choice across adolescence, and whether more lifetime drinks is associated with a greater change in impulsive choice across age. Design Alcohol-naïve adolescents, with varying degrees of FHD, were recruited as part of an ongoing longitudinal study on adolescent development, and were grouped based on whether they remained non-drinkers (n = 83) or initiated binge drinking (n = 33) during follow-up. During all visits, adolescents completed a monetary delay discounting task to measure impulsive choice. The effects of binge-drinking status, FHD, and their interaction on impulsive choice across adolescence were tested. Setting Developmental Brain Imaging Lab, Oregon Health & Science University, Portland, Oregon, USA. Participants 116 healthy male and female adolescents (ages 10–19) completed 2–4 visits between July 2008 and May 2016. Measurements Discounting rates were obtained based on adolescents’ preference for immediate or delayed rewards. FHD was based on parent-reported prevalence of alcohol use disorder in the participant’s first and second degree relatives. Binge-drinking status was determined based on the number of recent binge-drinking episodes. Findings There was a significant interaction effect of binge-drinking status and FHD on impulsive choice across age (b = 1.090, p < 0.05, β = 0.298). In adolescents who remained alcohol-naïve, greater FHD was associated with a steeper decrease in discounting rates across adolescence (b = −0.633, p < 0.05, β = −0.173); however, this effect was not present in binge-drinkers. Furthermore, total lifetime drinks predicted escalated impulsive choice (b = 0.002, p < 0.05, β = 0.295) in binge-drinking adolescents. Conclusions A greater degree of familial alcoholism is associated with a steeper decline in impulsive choice across adolescence, but only in those who remain alcohol-naïve. Meanwhile, more lifetime drinks during adolescence is associated with increases in impulsive choice across age.

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Binge drinking impacts dorsal striatal response during decision making in adolescents

Cited by 38 publications

References 66 publications

Face validity of a pre‐clinical model of operant binge drinking: just a question of speed

Face validity of a pre‐clinical model of operant binge drinking: just a question of speed

Adolescent neural response to reward is related to participant sex and task motivation

Binge drinking and family history of alcoholism are associated with an altered developmental trajectory of impulsive choice across adolescence

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