Binge Drinking During Pregnancy as a Predictor of Psychiatric Disorders on the  Structured Clinical Interview for DSM-IV in Young Adult Offspring

Barr, Helen M.; Bookstein, Fred L.; O’Malley, Kieran; Connor, Paul; Huggins, Janet E.; Streissguth, Ann P.

doi:10.1176/ajp.2006.163.6.1061

Cited by 140 publications

(49 citation statements)

References 25 publications

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“…Replications of these findings in human studies would provide support for a biological origin of some cases of early drinking through a 'programming' effect on the brain's natural reward circuitry and confirm emerging evidence pointing to in utero alcohol exposure in the development of addictions ([Alati et al, 2006], [Baer et al, 2003] and [Barr et al, 2006]). On the other hand, the possibility remains that the effect found is not explained by intrauterine mechanisms, but maybe due to shared familial, environmental and modelling factors, which existing studies have not been able to appropriately taken into account.…”

Section: Introductionsupporting

confidence: 60%

“…The evidence regarding a relationship between in utero alcohol exposure and early alcohol uptake in offspring is limited. Of the studies published to date, three have found an effect in early adulthood ([Alati et al, 2006], [Baer et al, 2003] and [Barr et al, 2006]). In this sample, the effect of in utero exposure to alcohol was not confined to the antenatal period, but appears to persist in childhood.…”

mentioning

confidence: 99%

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The developmental origin of adolescent alcohol use: Findings from the Mater University Study of Pregnancy and its outcomes

Alati¹,

Clavarino²,

Najman³

et al. 2008

Drug and Alcohol Dependence

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BackgroundIt is unclear whether fetal alcohol exposure contributes to alcohol use in adolescence. In this study, we examine the association between maternal alcohol use in pregnancy and adolescents' drinking patterns at age 14. MethodsThe association of maternal alcohol exposure with early drinking was examined in 4363 adolescents taking part to the Mater University Study of Pregnancy (MUSP) and its outcomes, a population based birth cohort study commenced in Brisbane (Australia) in 1981. Mothers and children were followed up at birth, 5 and 14 years after the initial interview. Maternal alcohol use was assessed before and during pregnancy and at the 5 years follow-up. Adolescents' alcohol use was assessed at child age 14. ResultsIn multivariable analysis those born of mothers who consumed 3+ glasses during pregnancy were at increased risk to report drinking 3+ glasses compared with those whose mothers reported no drinking or drinking up to 2 glasses. Comparisons controlling for drinking before pregnancy and at age 5 found the averaged odds ratio of maternal drinking in pregnancy on risk of reporting alcohol consumption of 3 and more glasses at age 14 was 2.74 (CI 1.70, 4.22). ConclusionOur study suggests that they maybe a biological origin of early drinking. Further studies are needed to better disentangle the nature of the association and the role of other possible confounding factors.

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Section: Introductionsupporting

confidence: 60%

mentioning

confidence: 99%

The developmental origin of adolescent alcohol use: Findings from the Mater University Study of Pregnancy and its outcomes

Alati¹,

Clavarino²,

Najman³

et al. 2008

Drug and Alcohol Dependence

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“…Pesquisas prévias demonstraram a associação entre fumo materno ou alcoolismo durante a gravidez e problemas do comportamento na infância e adolescência 46,47,48 . No nosso trabalho, após ajuste para fumo materno e consumo de álcool na gravidez, as associações entre déficit de peso e IMC para idade ao nascimento se mantiveram significativas.…”

Section: Discussionunclassified

Tamanho ao nascer e problemas de saúde mental aos 11 anos em uma coorte brasileira de nascimentos

et al. 2011

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O objetivo foi avaliar a associação entre tamanho ao nascer e problemas de saúde mental aos 11 anos na Coorte de Nascimentos de Pelotas, Rio Grande do Sul, Brasil, de 1993. Foram pesados e medidos ao nascer 4.358 recém-nascidos. Avaliou-se problemas de saúde mental com o questionário de capacidades e dificuldades (Strengths and Difficulties Questionnaire - SDQ). A prevalência de problemas de saúde mental foi de 32% (IC95%: 31-33). Na análise ajustada, os 291 (6,7%) recém-nascidos com escorez de peso/idade e os 268 (6,2%) com índice de massa corporal (IMC)/idade < -2 DP tiveram, respectivamente, 27% (IC95%: 7-49) e 29% (IC95%: 10-51) maior risco de apresentar problemas de saúde mental aos 11 anos quando comparados com aqueles com escore normal. Os 102 (2,43%) recém-nascidos com escorez de IMC e os 279 (6,4%) com perímetro cefálico/idade > +2 DP tiveram, respectivamente, 34% (IC95%: 6-71) e 19% (IC95%: 1-40) maior risco de apresentar esses problemas se comparados com aqueles com escore normal. Os resultados sugerem que fatores ocorridos na gestação e refletidos nas medidas de tamanho ao nascer podem ocasionar problemas de saúde mental em etapas tardias.

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“…Alcohol use in the family, paternal use in particular, has been linked to increased risk of child abuse, as well as future alcohol abuse by children themselves [51][52][53]. This can predispose children to behaviors that can perpetuate the occurrence of FASD as they grow into child bearing years [43,[51][52][53][54][55][56][57]. Therefore, a familial approach in the detection of alcohol use is important for advances in FASD research.…”

Section: Alcohol Use In the Family And Fasdmentioning

confidence: 99%

The fatty acid ethyl esters (FAEE) hair test: emerging technology for the diagnosis of fetal alcohol spectrum disorders (FASD)

Kulaga¹,

Pragst²,

Koren³

2009

Ann Toxicol Anal

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-Aim: Fetal alcohol spectrum disorder (FASD) is the most prevalent cause of neurocognitive handicap among North American children. A serious challenge in the diagnosis of FASD is the need to document excessive maternal drinking during pregnancy, however maternal self-report is often unreliable creating a need for an objective biomarker. Methodology: Testing for xenobiotics in hair has been gaining popularity in recent years as a screening method for drug use because of its unique advantage of being non-invasive and providing a stable, long-term record of past and or chronic drug exposure. The recent advent of a hair test to measure excessive alcohol use, the FAEE hair test, has opened the door to exploring its use as a new diagnostic tool for FASD. The current article briefly reviews recent advances in research involving the FAEE hair test in this context. Conclusion: Recent advances in research involving the FAEE hair test suggest that FAEE hair analysis may be a powerful tool in detecting heavy alcohol use in the perinatal period and in FASD diagnosis.Key words: Foetal alcoholism spectrum disorder biomarker, FAEE, hair testing Résumé -Objectif : Le syndrome d'alcoolisation foetal (SAF) est en Amérique du Nord la première cause de handicaps neuro-cognitifs chez l'enfant. Quantifier la consommation excessive pendant la grossesse apparaît crucial pour le diagnostic du SAF, cependant l'information fournie par la mère elle-même apparaît souvent peu fiable, et rend né-cessaire le recours à un marqueur biologique fiable. Méthodes : La recherche de xénobiotiques dans les cheveux s'est généralisée, ces dernières années, pour détecter l'usage de produits toxiques : elle présente l'avantage de ne pas être traumatique, tout en informant de façon continue, sur de longues périodes quant à l'exposition passée ou chronique à des xénobiotiques. L'arrivée récente d'un test capillaire pour évaluer la consommation excessive d'alcool -recherche et dosage des FAAE -a posé la question de son utilisation comme nouvel outil de diagnostic du SAF. Le présent article passe en revue les avancées récentes concernant l'utilisation du test FAAE dans ce contexte. Conclusion : Les recherches relatives au test FAAE montrent que l'analyse des cheveux par ce test peut se révéler un outil puissant pour détecter la consommation d'alcool à hautes doses en période prénatale, et peut être utilisé pour le dépistage du SAF.

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Binge Drinking During Pregnancy as a Predictor of Psychiatric Disorders on the Structured Clinical Interview for DSM-IV in Young Adult Offspring

Abstract: Prenatal exposure to alcohol may be a risk factor for specific psychiatric disorders and traits in early adulthood, even in a nonclinical group.

Cited by 140 publications

References 25 publications

The developmental origin of adolescent alcohol use: Findings from the Mater University Study of Pregnancy and its outcomes

The developmental origin of adolescent alcohol use: Findings from the Mater University Study of Pregnancy and its outcomes

Tamanho ao nascer e problemas de saúde mental aos 11 anos em uma coorte brasileira de nascimentos

The fatty acid ethyl esters (FAEE) hair test: emerging technology for the diagnosis of fetal alcohol spectrum disorders (FASD)

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