Binding, unbinding and aggregation of crescent-shaped nanoparticles on nanoscale tubular membranes

Spangler, Eric J.; Olinger, Alexander D.; Kumar, P. B. Sunil; Laradji, Mohamed

doi:10.1039/d0sm01642j

Cited by 5 publications

(3 citation statements)

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“…1,6–17 Many computational studies have been performed, during recent years, to investigate membrane-induced interactions between spherical NPs, 13,16 cap-shaped NPs, 18 and anisotropic NPs 19–21 including highly anisotropic crescent-shaped NPs. 14,22–26…”

Section: Introductionmentioning

confidence: 99%

“…1,[6][7][8][9][10][11][12][13][14][15][16][17] Many computational studies have been performed, during recent years, to investigate membrane-induced interactions between spherical NPs, 13,16 cap-shaped NPs, 18 and anisotropic NPs [19][20][21] including highly anisotropic crescent-shaped NPs. 14,[22][23][24][25][26] Janus NPs form a special class of nanomaterials which are designed to have two moieties with different chemical compositions. [27][28][29][30] Several studies have been performed to understand the interaction between Janus NPs and lipid membranes.…”

Section: Introductionmentioning

confidence: 99%

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Modes of adhesion of two Janus nanoparticles on the outer or inner side of lipid vesicles

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modes of adhesion of two Janus nanoparticles on the outer or inner side of lipid vesicles

et al. 2022

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“…Since then, research on Janus nanoparticles has been thriving, and they have received considerable attention due to their unique physical, chemical, and biological properties [ 8 ]. Different techniques such as masking, bottom-up assemblies, and controlled phase separation have been employed to synthesize Janus nanoparticles [ 9 , 10 ], and various Janus architectures have been created, such as cylindrical-shaped [ 11 ], dumbbell-shaped with asymmetric or snowman characters [ 12 , 13 , 14 , 15 , 16 , 17 ], mushroom-shaped [ 18 , 19 ], bowl-like [ 20 , 21 ], crescent-shaped [ 22 , 23 ], and half-raspberry-shaped structures [ 24 ]. Among these, dumbbell-like nanoparticles, as a prominent subset of Janus nanoparticles, have attracted significant interest due to their unique structure and excellent performance in various application domains, including drug delivery, catalysis, sensing, and advanced materials.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Asymmetric Al2O3-SiO2 Janus Nanoparticles in Aqueous Phase and Its Interfacial Property

Jia,

Xiao,

Yang

et al. 2024

Materials

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In this study, asymmetric Al2O3-SiO2 Janus nanoparticles with a dumbbell-like structure were synthesized by a facile chemical process in the aqueous phase. Prior to synthesis, Al2O3 nanoparticles in hydrosol were amino-modified using 3-aminopropyl triethoxysilane (KH550) and then carboxyl acid-functionalized using a ring-opening reaction of the amine functions with succinic anhydride, imparting unique anionic properties to the Al2O3 end. SiO2 nanoparticles were rendered hydrophobic through modification with hexamethyldisilazane (HMDS) and further functionalized with 3-chloropropyl triethoxysilane (KH230). The two nanoparticle hydrosols were then mixed, and the asymmetric Al2O3-SiO2 Janus nanoparticles were synthesized via the reaction between the –NH2 and −CH2Cl groups. The prepared Janus nanoparticles were primarily characterized by dynamic light scattering (DLS), Zeta potential (ZP), and transmission electron microscopy (TEM). The results indicated that about 90% of the modified Al2O3 and SiO2 nanoparticles were covalently coupled in a one-to-one manner to form the dominant dumbbell-like structure. These Janus nanoparticles exhibit amphiphilic properties, making them highly promising surfactants for emulsifying oil–water mixtures.

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Spatial arrangements of spherical nanoparticles on lipid vesicles

Spangler

Laradji

2021

The Journal of Chemical Physics

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We report results of a numerical investigation of the modes of adhesion of two spherical nanoparticles (NPs) on lipid vesicles based on molecular dynamics simulations, in conjunction with the weighted histogram analysis method, of an implicit-solvent model of self-assembled membranes. Our investigation shows that the NPs exhibit a sequence of three modes of adhesion. For low adhesive interactions, the adhering NPs are apart from each other. As the adhesive interaction is increased, the NPs dimerize into in-plane dimers. As the adhesive interaction is further increased for relatively large vesicles, the NPs dimerize into tubular dimers. However, for small vesicles, the tubular dimer state is not observed. For higher values of the adhesive interaction, four endocytosis modes are observed, depending on the initial locations of the NPs on the vesicle and the relative size of the NPs with respect to that of the vesicle. For relatively large vesicles, the NPs are endocytosed individually or as a dimer. For relatively small vesicles, only one NP is endocytosed if the initial distance between the NPs is large, while the second NP remains adhered to the outer leaflet of the vesicle. However, if the initial distance between the NPs is small, one NP is endocytosed, while the other is internalized in the vesicle through a pore.

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Binding, unbinding and aggregation of crescent-shaped nanoparticles on nanoscale tubular membranes

Abstract: Using molecular dynamics simulations of a coarse-grained implicit solvent model, we investigate the binding of crescent-shaped nanoparticles (NPs) on tubular lipid membranes. The NPs adhere to the membrane through their...

Cited by 5 publications

References 64 publications

Modes of adhesion of two Janus nanoparticles on the outer or inner side of lipid vesicles

Modes of adhesion of two Janus nanoparticles on the outer or inner side of lipid vesicles

Preparation of Asymmetric Al2O3-SiO2 Janus Nanoparticles in Aqueous Phase and Its Interfacial Property

Spatial arrangements of spherical nanoparticles on lipid vesicles

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