Binding studies and biological evaluation of β-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV

Naz, Huma; Khan, Parvez; Tarique, Mohd; Rahman, Safikur; Meena, Abha; Ahamad, Shahzaib; Luqman, Suaib; Islam, Asimul; Ahmad, Faizan; Hassan, Md. Imtaiyaz

doi:10.1016/j.ijbiomac.2016.12.024

Cited by 72 publications

(38 citation statements)

References 58 publications

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“…Moreover in recent studies, β-carotene has been proposed to decrease cell proliferation and induce apoptosis of various cancer cell lines by inhibiting calcium-/calmodulin-dependent protein kinase IV [65]. In another study, β-carotene has been reported to have anticancer stem cell actions on neuroblastoma, and this anticancer action is enhanced by retinoic acid receptor β [66].…”

Section: Antioxidant Functions Of Carotenoids At Molecular Level For mentioning

confidence: 98%

The Biochemistry and Antioxidant Properties of Carotenoids

Merhan¹

2017

Carotenoids

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Carotenoids are one of the most widespread pigment groups distributed in nature, and more than 700 natural carotenoids have been described so far, and new carotenoids are introduced each year. Carotenoids are derived from 4 terpenes, including totally 40 carbon atoms. Carotenoids are naturally synthesized by cyanobacteria, algae, plants, some fungi, and some bacteria, but not made by mammals. Lately, the beneficial properties of α-carotene, β-carotene, γ-carotene, lycopene, phytoene, phytofluene, lutein, zeaxanthin, β-cryptoxanthin, astaxanthin, and fucoxanthin carotenoids in prevention of various diseases, such as tumor formation, cardiovascular, and vision, have been documented due to their roles as antioxidants, activation in certain gene expression associated with cell-to-cell communication, provitamin A activity, modulation of lipoxygenase activity, and immune response. In this chapter, in addition to biochemical properties of carotenoids, how the structure of these molecules influences the oxidative stress in health and reducing the risk of formation of various diseases will be described.

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Section: Antioxidant Functions Of Carotenoids At Molecular Level For mentioning

confidence: 98%

The Biochemistry and Antioxidant Properties of Carotenoids

Merhan¹

2017

Carotenoids

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“…[31,52] Today, researchers from every field taking the support of docking to understand mode and strength of interaction at molecular level. [31,32,[53][54][55][56] In the present work, shape-based cholinium ion was docked with DNA duplex of sequence d(CGCGAATTCGCG)2 dodecamer (PDB ID: 1BNA) to predict the binding site and preferred orientation. The energetically most favorable conformation of the docked pose (Fig.…”

Section: Docking Studiesmentioning

confidence: 99%

Interaction studies of cholinium-based ionic liquids with calf thymus DNA: Spectrophotometric and computational methods

Haque

Khan

Hassan

et al. 2017

Journal of Molecular Liquids

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“…It has been shown that β-carotene is able to bind to the active site of CAMKIV with high affinity, thus forming a stable complex, resulting in decreased CAMKIV activity. This ability could make β-carotene an attractive target in cancer treatment, since it has shown no cytotoxic effects in vitro [53].…”

Section: β-Carotenementioning

confidence: 99%

Calcium-Involved Action of Phytochemicals: Carotenoids and Monoterpenes in the Brain

Rzajew

Radzik

Rębas

2020

IJMS

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Background: Neurodegenerative and mood disorders represent growing medical and social problems, many of which are provoked by oxidative stress, disruption in the metabolism of various neurotransmitters, and disturbances in calcium homeostasis. Biologically active plant compounds have been shown to exert a positive impact on the function of calcium in the central nervous system. Methods: The present paper reviews studies of naturally occurring terpenes and derivatives and the calcium-based aspects of their mechanisms of action, as these are known to act upon a number of targets linked to neurological prophylaxis and therapy. Results: Most of the studied phytochemicals possess anticancer, antioxidative, anti-inflammatory, and neuroprotective properties, and these have been used to reduce the risk of or treat neurological diseases. Conclusion: The neuroprotective actions of some phytochemicals may employ mechanisms based on regulation of calcium homeostasis and should be considered as therapeutic agents.

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Binding studies and biological evaluation of β-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV

Cited by 72 publications

References 58 publications

The Biochemistry and Antioxidant Properties of Carotenoids

The Biochemistry and Antioxidant Properties of Carotenoids

Interaction studies of cholinium-based ionic liquids with calf thymus DNA: Spectrophotometric and computational methods

Calcium-Involved Action of Phytochemicals: Carotenoids and Monoterpenes in the Brain

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