Binding of substance P to monolayers and vesicles made of phosphatidylcholine and/or phosphatidylserine

The temperature dependence and thermodynamic functions of partitioning of substance P peptides in dodecylphosphocholine micelles

“…cannot be accurately represented by a nonpolar bulk phase because of significant penetration of water Wimley and White 41 showed that in the incorporation of tryptophan side-chain analogues into bilayers into this region. Despite these conflicting estimates, the model of binding of SP via the hydrophobic side tition and the thermodynamic functions of partition, ensuring that the structural and thermodynamic chains is in agreement with the results of the work of Duplaa et al, 35 Seelig et al, 38 and with a molecular measurements are made on exactly the same systems. Recently, Russell et al 29 used temperaturedynamics (MD) simulation study of SP and SP [Tyr 8 ] in SDS micelles conducted in this laboradependent electron spin resonance (ESR) measurements to derive the thermodynamics function of partory.…”

“…Recently, Russell et al 29 used temperaturedynamics (MD) simulation study of SP and SP [Tyr 8 ] in SDS micelles conducted in this laboradependent electron spin resonance (ESR) measurements to derive the thermodynamics function of partory. 46 The study of Duplaa et al in vesicles 35 suggested at most the insertion of the last three (Gly 9 -titioning of Cox IVp peptides to lipid bilayers via the determination of f b as a function of temperature. Leu 10 -Met 11 ) residues of the SP peptide.…”

The study of the conformation and interaction of two tachykinin peptides in membrane mimicking systems by NMR spectroscopy and pulsed field gradient diffusion

“…12 The free energy of partitioning, ⌬G part was determined for these peptides from their partition coefficients, and their values range from Ϫ2. 10 , and Met 11 with the hydrophobic part of the bilayer. 8,40 The difference in the partition 47,48 Thus the partition results are consistent with the theoretical estimations.…”

“…14 SP has a random structure in aqueous solutions, but exhibits a partial helical structure in the presence of phospholipid bilayers, 7,10 lipid micelles, 11,12 and sodium dodecylsulfate (SDS) micelles. 12,13 NKA has been studied by nmr in water and in methanol, 15 in 28% trifluoroethanol (TFE)/water mixture, 16 and in 50 mM SDS micelles.…”

Thermodynamics of Partitioning of Substance P in Isotropic Acidic Bicelles

“…21 The interaction of an amphiphatic peptide, SP, containing eleven residues, with lipid monolayers or bilayers has been investigated extensively in the past. 4,5,22,23 The lipid membrane has been known to play an important role in the biological activity of SP either by increasing the concentration of SP at the surface of the membrane or by inducing and stabilizing the physiologically active conformation of SP.…”