Binding of Prolactin by Fetal Rhesus Cell Membrane Fractions12

Josimovich, John B.; Merisko, Karen; Boccella, Louise; Tobón, Héctor

doi:10.1210/endo-100-2-557

Cited by 49 publications

(12 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRL and PLs circulate in fetal serum [37,[43][44][45][46] and bind to receptors on fetal tissues in mammals [43,47,48]. PRL receptors express on fetal tissues including bones, lungs, adrenal glands, kidneys, the liver and skeletal muscles in rats and humans [49][50][51].…”

Section: Discussionmentioning

confidence: 99%

The Secretory Pattern and Source of Immunoreactive Prolactin in Pregnant African (Loxodonta africana) and Asian (Elephas maximus) Elephants

Yamamoto

Yuto

et al. 2012

J. Reprod. Dev.

View full text Add to dashboard Cite

Abstract. The objective of the present study was to define the secretion of prolactin (PRL) in pregnant African and Asian elephants. Levels of immunoreactive (ir-) PRL in serum and placental homogenates were measured by a heterologous radioimmunoassay (RIA) based on an ovine and human RIA system, and the localization of ir-PRL in the placenta was detected by immunohistochemistry using anti-human PRL. Circulating ir-PRL clearly showed a biphasic pattern during pregnancy in African and Asian elephants. Serum levels of ir-PRL started to increase from the 4 -6th month of gestation and reached the first peak level around the 11-14th month. A second peak of circulating ir-PRL levels was observed around the 18-20th month of gestation followed by an abrupt decline after parturition. In contrast, in a case of abortion of an African elephant, the second peak of ir-PRL was not observed, and the levels remained low for about four months until parturition. The weight of the fetus delivered at the 17th month of gestation was 23.5 kg, which was quite small compared with normal fetuses in previous reports. Ir-PRL was detected in placental homogenates, and immunolocalization was observed in trophoblasts in both the African and Asian elephants, indicating that the placenta is the source of ir-PRL during pregnancy in elephants. The present results clearly demonstrated that circulating ir-PRL shows a biphasic pattern during normal pregnancy and that the placenta appears to be an important source of circulating ir-PRL during pregnancy in both African and Asian elephants. Key words: Female elephant, Fetal growth, Placenta, Pregnancy, Prolactin (J. Reprod. Dev. 58: [105][106][107][108][109][110][111] 2012) G estation and parturition are dramatic events for a female animal. The secretion of prolactin (PRL) shows remarkable changes during gestation and at parturition in many species [1][2][3][4][5]. The major source of PRL is the anterior pituitary gland, and its major functions during mammalian gestation are development of the mammary glands and stimulation of milk production. PRL secretion is stimulated by several environmental factors including pregnancy, suckling stimulation and stress [2,[6][7][8][9][10][11][12].Reproductive endocrinology including secretion of PRL has been studied in elephants previously [13][14][15][16][17][18][19][20][21][22]. However, many mysteries, such as the source and the function of PRL during pregnancy, still remain. It is known that PRL is derived from the placenta in humans and rats [2,[23][24][25][26]. Placentation begins at the second to third month after ovulation in elephants [27]. The placenta ultimately forms a zonary shape, and its weight at term ranges from 8.3 to 22.2 kg in elephants [28].The objectives of the present study were to investigate the secretory pattern of immunoreactive (ir-) PRL in pregnant elephants. In addition, the immunoreactivity of ir-PRL was detected in the term placental tissues of both of African and Asian elephants by radioimmunoassay and immunohistochemistry. Materi...

show abstract

Section: Discussionmentioning

confidence: 99%

The Secretory Pattern and Source of Immunoreactive Prolactin in Pregnant African (Loxodonta africana) and Asian (Elephas maximus) Elephants

Yamamoto

Yuto

et al. 2012

J. Reprod. Dev.

View full text Add to dashboard Cite

show abstract

“…There is also evidence for a prolactin receptor in fetal monkey lung (258). On the other hand, two groups have failed to confirm the finding of Hamosh and Hamosh (177).…”

Section: Prolactinmentioning

confidence: 97%

Lung surfactant.

Rooney¹

1984

Environ Health Perspect

View full text Add to dashboard Cite

Aspects of pulmonary surfactant are reviewed from a biochemical perspective. The major emphasis is on the lipid components of surfactant. Topics reviewed include surfactant composition, cellular and subcellular sites as well as pathways of biosynthesis of phosphatidylcholine, disaturated phosphatidylcholine and phosphatidylglycerol. The surfactant system in the developing fetus and neonate is considered in terms of phospholipid content and composition, rates of precursor incorporation, activities of individual enzymes of phospholipid synthesis and glycogen content and metabolism. The influence of the following hormones and other factors on lung maturation and surfactant production is discussed: glucocorticoids, thyroid hormone, estrogen, prolactin, cyclic AMP, p-adrenergic and cholinergic agonists, prostaglandins and growth factors. The influence of maternal diabetes, fetal sex, stress and labor are also considered. Nonphysiologic and toxic agents which influence surfactant in the fetus, newborn and adult are reviewed.

show abstract

“…And yet the lactogenic hormones placental lactogen (PL) and prolactin (PRL) 1 circulate in fetal as well as postnatal serum (1)(2)(3)(4)(5)(6)(7) and bind with high affinity to mammalian fetal tissues in mid-and late gestation (4,6,(8)(9)(10)(11), during periods of active tissue differentiation, growth, and maturation.…”

Section: Introductionmentioning

confidence: 99%

Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.

et al. 1997

View full text Add to dashboard Cite

To explore potential roles for lactogenic hormones in human fetal development, we examined the distribution and ontogenesis of expression of prolactin receptors (PRLRs) in human fetal tissues at 7.5-14 wk of gestation and in tissues of the embryonic and fetal rat on days e12.5-e20.5. Histochemical analysis of PRLR immunoreactivity in the human fetus and fetal rat revealed novel and unexpected patterns of receptor expression. Most remarkable was the appearance in early fetal development of intense PRLR immunoreactivity in tissues derived from embryonic mesoderm, including the periadrenal and perinephric mesenchyme, the pulmonary and duodenal mesenchyme, the cardiac and skeletal myocytes, and the mesenchymal precartilage and maturing chondrocytes of the endochondral craniofacial and long bones, vertebrae and ribs. Striking changes in the cellular distribution and magnitude of expression of PRLRs were noted in many tissues during development. In the fetal adrenal the initial mesenchymal PRLR expression is succeeded by the emergence of PRLR immunoreactivity in deeper fetal cortical cell layers. In the fetal kidney and lung, the invagination of cortical mesenchyme is accompanied by progressive PRLR immunoreactivity in bronchial and renal tubular epithelial cells. In the pancreas, the PRLR is expressed primarily in acinar cells and ducts in early gestation; in late gestation and in the postnatal period, the PRLR is expressed predominantly in pancreatic islets, co-localizing with insulin and glucagon. Finally in fetal hepatocytes, PRLR immunoreactivity increases significantly between embryonic days e52 and e96 in the human fetus and between days e16.5 and e18.5 in the fetal rat. In addition to playing important roles in reproduction, lactation, and immune function, the lactogenic hormones likely play roles in tissue differentiation and organ development early in gestation. ( J. Clin. Invest. 1997. 99:1107-1117.)

show abstract

Binding of Prolactin by Fetal Rhesus Cell Membrane Fractions¹²

Cited by 49 publications

References 2 publications

The Secretory Pattern and Source of Immunoreactive Prolactin in Pregnant African (<i>Loxodonta africana</i>) and Asian (<i>Elephas maximus</i>) Elephants

The Secretory Pattern and Source of Immunoreactive Prolactin in Pregnant African (<i>Loxodonta africana</i>) and Asian (<i>Elephas maximus</i>) Elephants

Lung surfactant.

Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.

Contact Info

Product

Resources

About