Binding of Nitric Oxide to Iron(II) Porphyrins:  Radiative Association, Blackbody Infrared Radiative Dissociation, and Gas-Phase Association Equilibrium

Chen, Ounan; Groh, Susan E.; Liechty, and Alison; Ridge, D. P.

doi:10.1021/ja991477h

Cited by 66 publications

(66 citation statements)

References 15 publications

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“…A seminal study on the binding of NO to Fe III -heme and to model Fe II -and Fe III -porphyrin complexes by Ridge and his coworkers has provided quantitative data on metalloporphyrin-NO bond strengths. 20 They used a variety of experimental approaches (radiative association, blackbody infrared radiative dissociation and association equilibria) unveiling the potential of gas phase ion chemistry in yielding valuable information on intrinsic properties of nitrosyl complexes performing important biological roles.…”

Section: −12mentioning

confidence: 99%

Intrinsic Properties of Nitric Oxide Binding to Ferrous and Ferric Hemes

Chiavarino¹,

Crestoni²,

Fornarini³

2014

Croat. Chem. Acta

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Abstract. Gas phase studies offer an ideal medium whereby structural and reactivity properties of charged species may be unveiled in the absence of solvent, matrix or counterion effects. In this environment NO binds to iron(II)-and iron(III)-hemes with comparable kinetics and equilibrium parameters, conclusively elucidating the factors determining the widely different affinity in protic solvents or in heme proteins. IRMPD spectroscopy of the isolated species provides unambiguous characterization of the gaseous nitrosyl heme complexes.

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Section: −12mentioning

confidence: 99%

Intrinsic Properties of Nitric Oxide Binding to Ferrous and Ferric Hemes

Chiavarino¹,

Crestoni²,

Fornarini³

2014

Croat. Chem. Acta

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“…[5] The nitrosyl complex, FeÀheme(NO) + , is thus obtained by exposing Fe III À heme + to a stationary concentration of NO. As ionic species in the dilute gas phase are not amenable to conventional IR absorption spectroscopy, the tool of IR multiple photon dissociation (IRMPD) spectroscopy has been exploited, relying on the coupling of tandem mass spectrometry with the beamline of an IR free electron laser (FEL).…”

Section: àHemementioning

confidence: 99%

Direct Probe of NO Vibration in the Naked Ferric Heme Nitrosyl Complex

et al. 2008

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“…For instance, the loss of heme from hemoglobin [21] and myoglobin was probed by collisioninduced dissociation (CID) [22] and blackbody infrared dissociation [23]. Also, infrared multiphoton dissociation [24], radiative association, equilibrium and the kinetic methods have been used to estimate the binding strength of various axial complexes of metalloporphyrins [25].…”

mentioning

confidence: 99%

Axial Imidazole Binding Strengths in Porphyrinoid Cobalt(III) Complexes as Studied by Tandem Mass Spectrometry

Mishra

Worlinsky

Gilbert

et al. 2012

J. Am. Soc. Mass Spectrom.

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The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) in conjunction with the energy-variable collision-induced dissociation (CID) technique was used to compare the relative gas-phase binding strength of the axially coordinated imidazoles to the octahedral and square planar Co(III) porphyrinoid complex ions. The observed binding energies of these ligands were rationalized in terms of the effects of porphyrinoid core structure and meso-substitution on the electron density on the central Co(III) centers. Some of these trends were supported by DFT-based computational studies. The study highlights to which extend porphyrins vary from chlorins and chlorin analogues in their coordination abilities and to which extraordinary degree meso-thienyl-substituents influence the electronic structure of porphyrins. The study also defines further the scope and limits CID experiments can be used to interrogate the electronic structures of metalloporphyrin complexes.

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Binding of Nitric Oxide to Iron(II) Porphyrins: Radiative Association, Blackbody Infrared Radiative Dissociation, and Gas-Phase Association Equilibrium

Cited by 66 publications

References 15 publications

Intrinsic Properties of Nitric Oxide Binding to Ferrous and Ferric Hemes

Intrinsic Properties of Nitric Oxide Binding to Ferrous and Ferric Hemes

Direct Probe of NO Vibration in the Naked Ferric Heme Nitrosyl Complex

Axial Imidazole Binding Strengths in Porphyrinoid Cobalt(III) Complexes as Studied by Tandem Mass Spectrometry

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