Binding of nickel to human epidermis in vitro

Fullerton, Ann; Hoelgaard, Annie

doi:10.1111/j.1365-2133.1988.tb03482.x

Cited by 46 publications

(21 citation statements)

References 14 publications

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“…The use of a protecting cream such as DTPA‐HY prior to exposure fits into a comprehensive concept for patients sensitized to metals, who cannot thoroughly avoid allergen contact and who cannot wear protective gloves. There are further therapeutic options: Fullerton and Hoelgaard (26) showed that significant amounts of nickel remain bound to the epidermis after skin contact. Therefore it is worth washing the hands thoroughly after skin contact because considerable amounts can be washed off.…”

Section: Discussionmentioning

confidence: 99%

A cream containing the chelator DTPA (diethylenetriaminepenta‐acetic acid) can prevent contact allergic reactions to metals

et al. 2001

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Chelating agents in protective barrier creams have often been used in the prevention of allergic contact dermatitis to nickel. In a pilot study, we demonstrated the preventive effect of 10% diethylenetriaminepentaacetic acid (DTPA) in an oil-in-water emulsion in nickel-sensitized patients. Now we reproduced these results in a randomized, double-blind study. Additionally, we investigated the efficacy of the barrier cream in other clinically relevant metal allergies. Individuals sensitized to various metals had a significant decrease in positive patch test reactions after pre-treatment with the DTPA-cream: 2.5% nickel sulfate (24/28 positive without pre-treatment versus 1/28 with pre-treatment; p<0.0001), 5% nickel sulfate (30/32 versus 15/32; p=0.0003), 1% cobalt chloride (19/20 versus 6/20; p=0.001) and 5% copper sulfate (13/14 versus 5/14; p=0.02). However, the cream had no protective effect with 1% palladium chloride (17/23 versus 16/23) and with 0.5% potassium dichromate (9/13 versus 7/13). We conclude that the DTPA-cream clearly abrogates positive patch test reactions in nickel-, cobalt- and copper-sensitized subjects and that it may therefore be helpful in the management of allergic contact dermatitis.

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Section: Discussionmentioning

confidence: 99%

A cream containing the chelator DTPA (diethylenetriaminepenta‐acetic acid) can prevent contact allergic reactions to metals

et al. 2001

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“…Once nickel is through the stratum corneum, diffusion rates accelerate (51). Nickel is mostly accumulated in the stratum corneum where 90% is bound and only minor amounts are found in the lower layers, independent of the counter‐ion (52, 55, 56).…”

Section: Introductionmentioning

confidence: 99%

Nickel and cobalt allergy before and after nickel regulation – evaluation of a public health intervention

Thyssen

2011

Contact Dermatitis

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Over the 20th century, the frequent use of nickel in consumer products resulted in an increasing prevalence of nickel allergy. Risk items included suspenders in the 1950s-1960s; buttons, zippers and rivets in the 1970s; and ear-piercing jewellery in the 1980s. When subjects allergic to nickel were exposed to nickel in high concentrations, it often resulted in allergic nickel contact dermatitis and hand eczema. In 1990, the Danish government began to regulate consumer nickel exposure as a response to the increasing nickel allergy problem. In 1994, the EU Nickel Directive was passed, a regulation that was based on the Danish and Swedish nickel regulations. These major public health interventions were expected to change the epidemiology of nickel allergy and dermatitis in Europe. Furthermore, it was debated whether nickel would be replaced by cobalt in inexpensive jewellery and result in higher prevalence of cobalt allergy. An evaluation of the possible effects of the European nickel regulations is of importance to ensure protection of consumers and dermatitis patients. This doctoral thesis aimed to evaluate the effects of regulatory interventions on nickel exposure by investigating the development of nickel allergy and dermatitis before and after nickel regulation. Furthermore, a change in the association between nickel allergy and hand eczema was evaluated. The nickel spot test was validated to determine its value when used for screening purposes. Possible explanations for the persistence of nickel allergy were explored including genetic predisposition and consumer nickel exposure from jewellery and accessories. A cobalt spot test was developed and validated. Finally, it was evaluated whether a cobalt allergy epidemic had replaced the nickel allergy epidemic after nickel regulation in terms of increasing cobalt sensitization and cobalt exposure. The thesis showed that the prevalence of nickel allergy decreased significantly after nickel regulation in young Danish women from the general population (18-35 years) and in young Danish female dermatitis patients from a university patch test clinic (0-30 years). Stratification by ear-piercing status revealed that women ear pierced before 1990 had a significantly higher prevalence of nickel allergy and dermatitis than women ear pierced after 1990. Furthermore, the association between hand eczema and nickel allergy decreased in young women aged 18-35 years when a comparison was made between women who were patch tested and questioned in, respectively, 1990 and 2006. Despite the decreasing prevalence of nickel allergy, this condition remains prevalent in young Danish women, as about 10% are nickel allergic. Genetic predisposition to nickel allergy was evaluated by investigating the possible association between filaggrin null mutation status and nickel allergy. A positive association was found but it was also concluded that environmental nickel exposure is of much greater importance. Thus, of 354 consumer items purchased from 36 different stores in Copenhagen, 22% released ni...

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“…The integument is highly permeable, and not only serves as the sole respiratory surface, but may also be the predominant uptake route for metals such as Cd, Cu, and Pb (Vijver, Vink, Miermans and Van Gestel 2003). The structure, dimensions, and composition of epidermal surfaces have been widely used for assessing the effects of xenobiotics on molluscs (Gomot-de Vaufleury and Pihan, 2002), fish (Lamche and Burkhardt-Holm, 2000), amphibians (Fenoglio et al, 2009), and mammals (Fullerton and Hoelgaard, 1988;Iwata et al, 1999), but surprisingly in view of its anatomical features and direct interfacing with soil, not in earthworms. Thus, the main objective of the present investigation was to determine morphometrically the effect of a volcanic soil on the epidermis of a cosmopolitan endogeic earthworm species (Amynthas gracilis Kinberg, 1867; Megascolecidae) resident in the Azores by comparing populations with different exposure histories confined within mesocosms in field locations with and without volcanic activity.…”

Section: Introductionmentioning

confidence: 99%

Morphometry of the epidermis of an invasive megascoelecid earthworm (Amynthas gracilis, Kinberg 1867) inhabiting actively volcanic soils in the Azores archipelago

Cunha¹,

Campos²,

Montiel³

et al. 2011

Ecotoxicology and Environmental Safety

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a b s t r a c tFor the first time, the structure, dimensions, and composition of the epidermis of an invasive earthworm species that has successfully colonized hostile conditions in actively volcanic soil on São Miguel (Azores) have been measured. Metal concentrations in actively volcanic (Furnas) and volcanically inactive (Fajã) soils were similar; however, Furnas soil was characterised by elevated temperature (10 1C differential), relative hypoxia, extremely high CO 2 tension, and accompanying acidity. The epidermis of earthworm's resident at Fajã was approximately twice the thickness of the epidermis of conspecifics resident in Furnas soil. Reference worms transferred to Furnas soil for 14 days experienced an epidermal thinning of approximately 51%. In comparison, when Furnas earthworms were transferred to mesocosms at the relatively benign Fajã site, their epidermal thickness increased by approximately 21% over 14 days. Earthworms resident in Furnas soil had higher goblet cell counts than the residents of volcanically inactive soil on a neighbouring island (S. Maria). Transferring worms from S. Maria to mesocosms at Furnas induced a significant increase in goblet cell counts. Clearly, the active volcanic environment at Furnas poses a multifactorial stress challenge to the epigeic A. gracilis colonizer.

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Binding of nickel to human epidermis in vitro

Cited by 46 publications

References 14 publications

A cream containing the chelator DTPA (diethylenetriaminepenta‐acetic acid) can prevent contact allergic reactions to metals

A cream containing the chelator DTPA (diethylenetriaminepenta‐acetic acid) can prevent contact allergic reactions to metals

Nickel and cobalt allergy before and after nickel regulation – evaluation of a public health intervention

Morphometry of the epidermis of an invasive megascoelecid earthworm (Amynthas gracilis, Kinberg 1867) inhabiting actively volcanic soils in the Azores archipelago

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