Binding of Murine Antibodies Against Whole‐Cell Pertussis Vaccine or Filamentous Haemagglutinin by Bordetella pertussis from Patients with Whooping Cough
Abstract:In 1996 an unexpected rise in the incidence of whooping cough occurred in the Netherlands, and antigenic divergence between vaccine strains and clinical isolates has been suggested as a cause for this phenomenon. To investigate this assumption, the binding of murine antibodies against the whole-cell pertussis vaccine or filamentous haemagglutinin, an important protective antigen, to a limited number of Bordetella pertussis strains isolated during different time-periods (1991-92, 1994 and 1996) was assessed. Th… Show more
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