Binding of metal ions to polysaccharides. V.

Balt, S.; Bolster, M. W. G. De; Booij, Meindert; Herk, Alex M. van; Visser-Luirink, Gesina

doi:10.1016/0162-0134(83)85026-0

Cited by 18 publications

(5 citation statements)

References 25 publications

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“…In this study, it has been found that the structure of the ytterbium-polysaccharide complex in solution is similar to that of calcium-C4S, in which Ca ++ coordinates to the carboxylate group. The same workers [38] reported a study in which the binding of metal ions, such as Cu ++ and Na + , to polysaccharides was investigated. In this report, Authors elucidated that the site binding of chondroitin sulphate is localised into the carboxylate group and the sulphate group binds the ions with electrostatic interaction only.…”

Section: Cs As Metal Ion Chelatormentioning

confidence: 96%

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Campo¹,

Avenoso²,

Campo³

et al. 2006

MRMC

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Most biological molecules exhibit more than one function. In particular, many molecules have the ability to directly/indirectly scavenge free radicals and thus act in living organisms as antioxidant. During oxidative stress, the increase of these molecules levels seems to be a biological response that in synergism with the other antioxidant defence systems may protect cells from oxidation. Among these structures, chondroitin sulphate is a biomolecule which has increasingly focused the interest of many research groups due to its antioxidant activity. This review briefly summarises the action of chondroitin sulphate in reducing molecular damage caused by free radicals and associated oxygen reactants.

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Section: Cs As Metal Ion Chelatormentioning

confidence: 96%

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Campo¹,

Avenoso²,

Campo³

et al. 2006

MRMC

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“…In a more recent study of the interaction of Cu(II) with CSA, interation through the carboxylate group was also demonstrated, whereas the nitrogen atom of the N-acetyl group appeared not to be involved in bonding (23).…”

Section: Hl_mentioning

confidence: 96%

“…On the other hand, in all similar systems formerly investigated, it was also found that the sulfate groups were not involved in bonding. They participate only in electrostatic interactions with the cations (18,23).…”

Section: Hl_mentioning

confidence: 99%

The interaction of the vanadyl (IV) cation with chondroitin sulfate A

Etcheverry

Williams

Baran

1994

Biol Trace Elem Res

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The interaction of VO2+ with the muchopolysaccharide chondroitin sulfate A (CSA) has been investigated by electron absorption spectroscopy and infrared measurements in aqueous solutions at different pH-values and ligand to metal ratios up to 6:1. The generation of a VO(CSA)2 species could be demonstrated. Coordination of the oxocation through the carboxylate group and the glycosidic oxygen of the D-glucuronate moieties is suggested. Infrared spectra of some poorly characterized solid VO/CSA complexes point to the same bonding characteristics. Preliminary results obtained at higher ligand to metal ratios suggest a different coordination behavior.

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“…A fructose‐containing polysaccharide with a chondroitin backbone from E. coli also effectively inhibited human low‐density lipoprotein (LDL) oxidation [18,19] . The mechanism of action to demonstrate the antioxidant potency is exhibited by the chelation capability with the transition metals, namely Fe 2+ and Cu 2+ [21,22] . Understanding CSs’ antioxidant capacity would be useful for designing new therapeutic molecules for oxidative stress‐induced diseases.…”

Section: Introductionmentioning

confidence: 99%

“…[18,19] The mechanism of action to demonstrate the antioxidant potency is exhibited by the chelation capability with the transition metals, namely Fe 2 + and Cu 2 + . [21,22] Understanding CSs' antioxidant capacity would be useful for designing new therapeutic molecules for oxidative stress-induced diseases.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Antioxidant, Anticholinesterase, and Antibacterial Activity of Microbial Chondroitin Sulfate and Commercial Chondroitin Sulfate

Unver,

Erenler,

Bingul

et al. 2023

Chemistry & Biodiversity

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Chondroitin synthesis was performed using the recombinant Escherichia coli (C2987) strain created by transforming the plasmid pETM6‐PACF‐vgb, which carries the genes responsible for chondroitin synthesis, kfoA, kfoC, kfoF, and the Vitreoscilla hemoglobin gene (vgb). Then, Microbial chondroitin sulfate (MCS)'s antioxidant, anticholinesterase, and antibacterial activity were compared with commercial chondroitin sulfate (CCS). The antioxidant studies revealed that the MCS and CCS samples could be potential targets for scavenging radicals and cupric ion reduction. MCS demonstrated better antioxidant properties in the ABTS assay with the IC50 value of 0.66 mg than CCS. MCS showed 2.5‐fold for DPPH and almost 5‐fold for ABTS•+ (with a value of 3.85 mg/mL) better activity than the CCS. However, the compounds were not active for cholinesterase enzyme inhibitions. In the antibacterial assay, the Minimum inhibitory concentration (MIC) values of MCS against S. aureus, E. aerogenes, E. coli, P. aeruginosa, and K. pneumoniae (0.12, 0.18, 0.12, 0.18, and 0.18 g/mL, respectively) were found to be greater than that of CCS (0.42, 0.48, 0.36, 0.36, and 0.36 g/mL, respectively). This study demonstrates that MCS is a potent pharmacological agent due to its physicochemical properties, and its usability as a therapeutic‐preventive agent will shed light on future studies.

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Binding of metal ions to polysaccharides. V.

Cited by 18 publications

References 25 publications

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

The interaction of the vanadyl (IV) cation with chondroitin sulfate A

Comparative Analysis of Antioxidant, Anticholinesterase, and Antibacterial Activity of Microbial Chondroitin Sulfate and Commercial Chondroitin Sulfate

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