Binding of Histamine by Animal Proteins

Kaplan, E.H.; Davis, Jane S.

doi:10.3181/00379727-84-20594

Cited by 16 publications

(3 citation statements)

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“…It has been suggested that histamine combines with proteins [e.g. Parrot, Urquia and Laborde, 1951;Rocha e Silva, 1955], but in vitro studies performed with various purified proteins have not confirmed this [Kaplan and Davis, 1953;Beall, 1964]. As heparin was used as anticoagulant in the present experiments, the binding of histamine by this substance, as demonstrated by Kobayashi [1962], is also of interest.…”

Section: Discussionmentioning

confidence: 71%

Inactivation of Histamine and Occurrence of Smooth Muscle Stimulating Activity in Plasma of Sheep

Sjaastad¹

1967

Exp Physiol

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With incubation periods of 90 min., histamine inactivation in sheep plasma was nearly proportional to substrate concentration within the range of 2 to about 50 ,ug. histamine diphosphate/ml. plasma. Increasing the substrate concentration above 80 ,ug./ml. did not increase the histamine inactivation. At optimal substrate concentrations (80 pig./ml. plasma), a histamine inactivating capacity of 42-1±4-8 ,pg.histamine diphosphate/ml. plasma/hr. was found in seventeen sheep examined. About 80 per cent of the histamine inactivation was abolished by aminoguanidine, indicating that oxidative deamination is the major route of inactivation in sheep plasma in vitro.When plasma was incubated for more than 60 min. with an initial histamine concentration less than 20 ,ug./ml., smooth muscle stimulating activity interfering with the biological determination of histamine, was observed. Such activity developed rapidly when glass powder was added to plasma prepared with siliconized equipment and it is concluded that the interfering activity is due to substance(s) resembling bradykinin.

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Section: Discussionmentioning

confidence: 71%

Inactivation of Histamine and Occurrence of Smooth Muscle Stimulating Activity in Plasma of Sheep

Sjaastad¹

1967

Exp Physiol

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“…As mentioned earlier K aplan and Davis also failed to demonstrate protein binding using a sensitive tech nique with equilibrium dialysis (4). In connection with a nice demonstration of histamine binding by heparin, K obayashi (11) was unable to find any significant evidence of histamine binding to the acidic proteins, casein, edestin, zein and gliadin.…”

Section: Gel Filtration (10)mentioning

confidence: 94%

Is Histamine Bound by Serum Proteins?

Beall¹

1964

Int Arch Allergy Immunol

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“…245 A counterforce deterrent also appeared more credible as an extended deterrent strategy for NATO and as an answer to possible Soviet "salami tactics." 246 During a 1962 speech to NATO ministers in Athens, Secretary McNamara officially announced the change in US strategy from one of massive retaliation to one of flexible response. With its heavy emphasis on counterforce targeting, the new strategy appeared to affirm the counterforce targeting position.…”

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confidence: 99%

Airpower and the Cult of the Offensive

Carter¹

1998

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Binding of Histamine by Animal Proteins

Cited by 16 publications

References 0 publications

Inactivation of Histamine and Occurrence of Smooth Muscle Stimulating Activity in Plasma of Sheep

Inactivation of Histamine and Occurrence of Smooth Muscle Stimulating Activity in Plasma of Sheep

Is Histamine Bound by Serum Proteins?

Airpower and the Cult of the Offensive

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