Binding of Cyproterone Acetate to Plasma Proteins

Sammelwitz, P. H.; Schreck, Carl B.; Hopwood, M. L.

doi:10.3181/00379727-143-37283

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1974

1990

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Cited by 5 publications

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“…However, from these data we cannot conclude at present whether or not an effect on testosterone-binding globulin (TeBG) by CA could account for part of the T fall observed in the in vivo study. In fact, the data concerning the binding capacity of CA to TeBG are controversial (15)(16)(17). Besides, in all experiments in rats, CA was still able to decrease T blood levels (1), although TeBG does not occur in the rat (18).…”

Section: Discussionmentioning

confidence: 93%

Effect of Cyproterone Acetate Acutely Administered on the Pituitary-Testicular Axis

D’Agata¹,

Gulizia²,

Vicari³

et al. 1979

Horm Res

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The effect of cyproterone acetate (CA) on the pituitary-testicular axis was studied in 6 healthy men. A dose of 300 mg of CA was administered orally in the early morning, after 3 h blood samples were collected using a multiple sample technique. Testosterone (T) levels were decreased by CA in all subjects (p 0.01), LH in all (p < 0.01) but one whereas 17-hydroxyprogesterone did not show any significant variation. In vitro, using an equilibrium dialysis, CA displaced T from plasma-binding proteins in males at 37 °C. The role of testosterone-binding globulin on the effects of CA on the pituitary-testicular axis remains to be clarified.

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