Binding of Corticosteroids by Plasma Proteins. Iii. The Binding of Corticosteroid and Related Hormones by Human Plasma and Plasma Protein Fractions as Measured by Equilibrium Dialysis12

Daughaday, William H.

doi:10.1172/jci103632

Cited by 168 publications

(35 citation statements)

References 9 publications

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“…The delayed clearance of exogenous tetrahydrocortisone, a steroid not bound in any significant degree by corticosteroid-binding globulin (18), cannot be explained by increases in the binding capacity of this protein. The existence of a protein-binding system for tetrahydrocortisone, as yet undescribed, which may be influenced by the administration of estrogens, should be considered.…”

Section: Methodsmentioning

confidence: 98%

Studies on the Mechanism of the Plasma 17-Hydroxycorticosteroid Elevation Induced in Man by Estrogens*

Wallace¹,

Carter²

1960

J. Clin. Invest.

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The administration of estrogens to man produces sustained elevation above normal levels of plasma (1, 2). The elevated levels of plasma 17-OHCS are associated with an augmented response of plasma levels of these steroids to exogenous adrenocorticotropic hormone (ACTH) and with a marked delay in the rate of clearance of exogenous cortisol from plasma (2). The last trimester of pregnancy is associated with similar changes in levels of plasma 17-OHCS and in their response to exogenous ACTH (3-9). In the last trimester of pregnancy there is a variable increase in urinary 17-OHCS excretion, a decrease in the rate of clearance of exogenous cortisol from plasma (9-11), a decrease in the rate of clearance of exogenous tetrahydrocortisone from plasma (11) and an increase in corticosteroid-binding protein (12). The apparently normal adrenal status of pregnant women and of patients treated with estrogens for long periods of time suggests that the administration of estrogens to man elevates plasma 17-OHCS levels by altering the normal metabolism of endogenous cortisol by a mechanism similar to that seen in pregnancy. Studies have been made of urinary 17-OHCS excretion, of clearance of tetrahydrocortisone from plasma, and of plasma corticosteroid-binding protein after the administration of estrogens to man. MATERIALS AND METHODSThe patients studied were primarily adult females ranging in age from 37 to 75 years, all of whom either had been surgically castrated or were at least 3 years past a spontaneous menopause. A number of these subjects were patients with metastatic carcinoma of the * This work was supported in part by a research grant from The National Cancer Institute, Bethesda, Md. breast. One male was studied during recovery from a myocardial infarction.After appropriate control studies, the patients were treated for periods of 2 weeks to 6 months with either oral ethinyl estradiol (Estinyl), diethylstilbestrol or conjugated equine estrogens (Premarin). Only doses of these preparations which uniformly elevated plasma 17-OHCS levels above normal were used in the studies (Table I). Ethinyl estradiol 0.1 and 0.5 mg, diethylstilbestrol 15 mg, and Premarin 10 mg, daily by mouth, all caused significant increases in the levels of plasma 17-OHCS.The effect of oral ethinyl estradiol, 0.5 mg daily, on urinary excretion of free and total 17-OHCS and of 17-ketosteroids was studied. Twenty-four hour urinary excretion of steroids was determined in each patient before estrogen therapy and again after plasma 17-OHCS

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Section: Methodsmentioning

confidence: 98%

Studies on the Mechanism of the Plasma 17-Hydroxycorticosteroid Elevation Induced in Man by Estrogens*

Wallace¹,

Carter²

1960

J. Clin. Invest.

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“…The increase in corticosterone secretion during chronic GH deficiency, which would be a logical consequence of our experiments, may be a factor in the hyoglycemia frequently seen in GH-deficient children. Although both cortisol and corticosterone are bound to the glucocorticoid-binding protein, the protein has a greater afiinity for cortisol (19). Thus, a greater amount of corticosterone would be unbound and available to the receptor for glucocorticoids.…”

Section: Discussiokmentioning

confidence: 99%

Modulation of Glucocorticoid Secretion by Growth Hormone

Chasalow

Blethen

1985

Pediatr Res

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“…Subsequent experiments with carbon labeled steroids using dialysis equilibrium suggested the possibility that there were two important corticosteroid binding proteins of human plasma (4). The first of these binding systems probably accounts for nearly all the binding of cortisol at normal physiologic concentrations.…”

mentioning

confidence: 99%

Binding of Corticosteroids by Plasma Proteins. Iv. The Electrophoretic Demonstration of Corticosteroid Binding Globulin12

Daughaday¹

1958

J. Clin. Invest.

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100

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Binding of Corticosteroids by Plasma Proteins. Iii. The Binding of Corticosteroid and Related Hormones by Human Plasma and Plasma Protein Fractions as Measured by Equilibrium Dialysis12

Cited by 168 publications

References 9 publications

Studies on the Mechanism of the Plasma 17-Hydroxycorticosteroid Elevation Induced in Man by Estrogens*

Studies on the Mechanism of the Plasma 17-Hydroxycorticosteroid Elevation Induced in Man by Estrogens*

Modulation of Glucocorticoid Secretion by Growth Hormone

Binding of Corticosteroids by Plasma Proteins. Iv. The Electrophoretic Demonstration of Corticosteroid Binding Globulin12

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