“…Each subunit monomer has two Ca 2+ -binding sites and shows Ca 2+ -dependent binding to many different ligands, including certain oligosaccharides, glycosaminoglycans (Hamazaki 1987), fibronectin , C-reactive protein (Swanson et al, 1992), aggregated IgG (Brown and Anderson 1993), C1q (Sorensen et al, 1996), complement C4-binding protein (Sorensen et al, 1996), DNA (Pepys and Butler 1987), chromatin (Breathnach et al, 1989), histones (Hicks et al, 1992), and phosphoethanolamine-containing compounds such as phosphatidylethanolamine (Emsley et al, 1994). Interaction with these ligands localises SAP to elastic microfibrils , glomerular and alveolar basement membrane, arterioles, bronchioles, sarcolemma of cardiac and smooth muscle (Dyck et al, 1980), and all forms of amyloid .…”