Binding of CD157 Protein to Fibronectin Regulates Cell Adhesion and Spreading

Morone, Simona; Augeri, Stefania; Cuccioloni, Massimiliano; Mozzicafreddo, Matteo; Angeletti, Mauro; Buono, Nicola Lo; Giacomino, Alice; Ortolan, Erika; Funaro, Ada

doi:10.1074/jbc.m113.535070

Cited by 26 publications

(29 citation statements)

References 38 publications

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“…More recent studies have shown that CD157 regulates cell adhesion to the extracellular matrix (ECM) [19] and binds selected ECM proteins, including fibronectin [20] which has a central role in mesenchymal differentiation [21]. This data indicates that CD157 is involved in EMT and suggests that the CD157/ECM interplay in the tumor microenvironment could be critical in determining the aggressiveness of CD157-positive tumors by facilitating the EMT differentiation program ongoing in biphasic MPM [5, 22].…”

Section: Discussionmentioning

confidence: 99%

CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome

et al. 2014

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Malignant mesothelioma is a deadly tumor whose diagnosis and treatment remain very challenging. There is an urgent need to advance our understanding of mesothelioma biology and to identify new molecular markers for improving management of patients. CD157 is a membrane glycoprotein linked to ovarian cancer progression and mesenchymal differentiation. The common embryonic origin of ovarian epithelial cells and mesothelial cells and the evident similarities between ovarian and mesothelial cancer prompted us to investigate the biological role and clinical significance of CD157 in malignant pleural mesothelioma (MPM).CD157 mRNA and protein were detected in four of nine MPM cell lines of diverse histotype and in 85.2% of MPM surgical tissue samples (32/37 epithelioid; 37/44 biphasic). CD157 expression correlated with clinical aggressiveness in biphasic MPM. Indeed, high CD157 was a negative prognostic factor and an independent predictor of poor survival for patients with biphasic MPM by multivariate survival analysis (HR = 2.433, 95% CI 1.120-5.284; p = 0.025). In mesothelioma cell lines, CD157 gain (in CD157-negative cells) or knockdown (in CD157-positive cells) affected cell growth, migration, invasion and tumorigenicity, most notably in biphasic MPM cell lines. In these cells, CD157 expression was associated with increased activation of the mTOR signaling pathway, resulting in decreased platinum sensitivity. Moreover, a trend towards reduced survival was observed in patients with biphasic MPM receiving postoperative platinum-based chemotherapy. These findings indicate that CD157 is implicated in multiple aspects of MPM progression and suggest that CD157 expression could be used to stratify patients into different prognostic groups or to select patients that might benefit from particular chemotherapeutic approach.

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Section: Discussionmentioning

confidence: 99%

CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome

et al. 2014

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“…It was reported that BST-1 promotes pre-B-cell growth and is involved in early T-cell development (30). As reported by Morone et al CD157 plays a crucial role in cell-extracellular matrix interaction (33). As reported by Morone et al CD157 plays a crucial role in cell-extracellular matrix interaction (33).…”

Section: Introductionmentioning

confidence: 92%

“…CD157 is a crucial factor for the mobility of human neutrophils (31,32) and is involved in the transmigration of monocytes (29). As reported by Morone et al CD157 plays a crucial role in cell-extracellular matrix interaction (33). In mesenchymal stem cells BST-1 has pivotal regulatory functions (34).…”

Section: Introductionmentioning

confidence: 93%

The Monoclonal Anti‐CD157 Antibody Clone SY11B5, Used for High Sensitivity Detection of PNH Clones on WBCs, Fails to Detect a Common Polymorphic Variant Encoded by BST‐1

Blaha

Schwarz

Schauwecker

et al. 2018

Cytometry Part B Clinical

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“…Despite not containing intracellular domains, CD157 was able to interact with integrins CD18 and CD29 on human neutrophils and monocytes, forming supramolecular complexes that activated signaling pathways to modulate transendothelial migration and adhesion to extracellular matrix components [81,82]. A number of extracellular matrix proteins containing heparin-binding domains were indeed shown to be high affinity non-substrate ligands for CD157, including fibronectin and fibrinogen [81,83].…”

Section: Cd157 a Cd38 Paralogue Is Important For The Host Response mentioning

confidence: 99%

Roles of CD38 in the Immune Response to Infection

Glaría

Valledor

2020

Cells

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CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker. Studies in animal models indicate that CD38 functional expression confers protection against infection by several bacterial and parasitic pathogens. In addition, infectious complications are associated with anti-CD38 immunotherapy. Although CD38 displays receptor and enzymatic activities that contribute to the establishment of an effective immune response, recent work raises the possibility that CD38 might also enhance the immunosuppressive potential of regulatory leukocytes. This review integrates the current knowledge on the diversity of functions mediated by CD38 in the host defense to infection.

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Binding of CD157 Protein to Fibronectin Regulates Cell Adhesion and Spreading

Cited by 26 publications

References 38 publications

CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome

CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome

The Monoclonal Anti‐CD157 Antibody Clone SY11B5, Used for High Sensitivity Detection of PNH Clones on WBCs, Fails to Detect a Common Polymorphic Variant Encoded by BST‐1

Roles of CD38 in the Immune Response to Infection

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