Binding of an Anti-Fullerene IgG Monoclonal Antibody to Single Wall Carbon Nanotubes

Erlanger, Bernard F.; Chen, Bi-Xing; Zhu, Min; Brus, L. E.

doi:10.1021/nl015570r

Cited by 204 publications

(134 citation statements)

References 13 publications

(18 reference statements)

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“…The most common route to improvement in reactivity and sensitivity is through functionalization of CNT sidewalls with specific bio/chemical molecules. [4][5][6]8 In fact, chemical functionalization can both ensure better chemical bonding between the nanotube and a specific chemical species as well as improve the selectivity of the adsorption process.Alternatively, metal nanoparticles can be used to functionalize CNTs, enabling attachment of other species. Indeed, nanotubes coated with Pd nanoparticles become excellent H 2 sensors.…”

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confidence: 99%

Carbon Nanotube−Metal Cluster Composites: A New Road to Chemical Sensors?

et al. 2005

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Novel carbon nanotube−metal cluster structures are proposed as prototype systems for molecular recognition at the nanoscale. Ab initio calculations show that already the bare nanotube cluster system displays some specificity because the adsorption of ammonia on a carbon nanotube−Al cluster system is easily detected electrically, while diborane adsorption does not provide an electrical signature. Since there are well-established procedures for attaching molecular receptors to metal clusters, these results provide a "proof-of-principle" for the development of novel, high-specificity molecular sensors.Since their discovery in 1991, carbon nanotubes (CNTs) have become one of the most exciting nanomaterials, combining a range of extraordinary physical properties, such as extremely small size and high aspect ratio, high stiffness and excellent flexibility under different mechanical stimuli, high structural and chemical stability, and a rich spectrum of electrical properties. Many potential applications have been proposed: superstrong composites, energy storage and energy conversion devices, field emission displays, mechanical, chemical and biological probes and sensors, radiation sources, nanoelectronic devices, and more. 1 In this letter we concentrate on the possibility of using carbon nanotubes as chemical sensors and probes. Pioneering experiments from Dai's group 2,3 have shown that at room temperature the resistance of an individual single wall carbon nanotube is very responsive to the adsorption of molecules, such as NO 2 and NH 3 . These measurements demonstrate the excellent sensing capabilities of CNTs, in particular their fast response time, high selectivity, and reversibility. It has also been shown that CNT-based single-molecule biosensors 4-6 can compete with other nanowire nanosensors 7 in detecting biological and chemical molecules. If appropriately functionalized, carbon nanotubes even have the ability to recognize proteins and DNA. [8][9][10] Moreover, their intrinsic strength and resilience makes them ideally suited for ultrasmall sensors capable of exploring complicated geometries at the nanoscale. 5,6 Real-world applications, such as CNTbased resonant-circuit wireless ammonia sensors, have been developed by different groups. 11,12 Due to their strong sp 2 bonding and near perfect hexagonal network, carbon nanotubes are chemically stable and do not form strong chemical bonds with most molecules. However, since experiments have shown that the properties of a CNT can change when it is immersed in a specific chemical or biological environment, there has been a substantial effort toward the development of techniques to enhance the sensing capability of CNTs. The most common route to improvement in reactivity and sensitivity is through functionalization of CNT sidewalls with specific bio/chemical molecules. [4][5][6]8 In fact, chemical functionalization can both ensure better chemical bonding between the nanotube and a specific chemical species as well as improve the selectivity of the adsorptio...

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confidence: 99%

Carbon Nanotube−Metal Cluster Composites: A New Road to Chemical Sensors?

et al. 2005

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“…The hydrophobic structure of the peptide chains suggests that they act as symmetric detergents. An IgG monoclonal antibody against the fullerene C 60 (Braden et al, 2000) was also studied to show binding to CNTs with some selectivity (Erlanger et al, 2001). The combination of multiwalled carbon nanotubes (MWCNT) as a transducer with polysulfone (PS) polymer enables easy incorporation of biological moieties (hormones or antibodies).…”

Section: Methods Of Immobilization Of Biomolecules On Cntsmentioning

confidence: 99%

Carbon Nanotubes - A Potential Material for Affinity Biosensors

Rao¹,

Suresh²,

Sharma³

et al. 2011

Carbon Nanotubes - Growth and Applications

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“…In certain circumstances, the molecules are directly adsorbed to either the nanomaterial surface or the shell of stabilizing molecules around the nanomaterial [85]. For example, direct binding of fullerenespecific monoclonal antibodies to single walled carbon nanotubes [86] and entropic effects driving adsorption of calf thymus DNA to CdS NPs [87] have been demonstrated as possible attachment methods. However, for both of these cases, stability is poor.…”

Section: Attachment Of Biomolecules To Nanomaterialsmentioning

confidence: 99%

Nano-bio interfaces probed by advanced optical spectroscopy: From model system studies to optical biosensors

Zhang

Han

et al. 2013

Chin. Sci. Bull.

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Research in biology and medicine is a rapidly expanding field incorporating some of the most fundamental questions concerning structure, function, and purpose. The forefront of new research demands access to advanced techniques and instrumentation capable of probing these unanswered questions. Over the past several decades, nano-scale materials and devices ranging from quasione dimensional quantum dots to two dimensional graphene sheets have been engineered and have found applications in nano-bio imaging and spectroscopy. In this review, the incorporation of nanomaterials into three influential spectroscopic and microscopic techniques including fluorescence microscopy, surface plasmon resonance, and sum frequency generation will be introduced. Fluorescence imaging has visualized nanomaterials as compliments or replacements to comparable organic fluorphores, act as a quencher for FRET-based sensing, and serve as a nanoscaffold for molecular beacons. Their versatility in coating materials makes nanomaterials an excellent targeting molecule for any cellular macromolecule or structure. In addition to the targeting capabilities of nanomaterials in fluorescence imaging, surface plasmon resonance has incorporated nanomaterials for applications in signal enhancement, selectivity of target molecules, and the development of more refined and accurate detection. Functionalized nanoparticles enhance the capabilities of sum frequency generation vibrational spectroscopy by providing unique surface chemistry which alters target molecule interactions and orientations. In summary, the incorporation of nanomaterials has greatly enhanced the field of biology and medicine and has allowed for the continual advancement of not only research but instrument development. nano-bio interfaces, optical spectroscopy, fluoroscence, SERS, SFG Citation:Zhang X X, Han X F, Wu F G, et al. Nano-bio interfaces probed by advanced optical spectroscopy: From model system studies to optical biosensors. Chin Sci Bull, 2013, 58: 25372556, doi: 10.1007/s11434-013-5700-y Nanomaterials, which size ranges (1-100 nm) coincide with fundamentally important length scales in physics, are considered to be promising building blocks for future electrical, optical and optoelectronic applications [1][2][3][4][5][6][7][8]. For example, in metals, the mean free path of an electron at room temperature is ~10-100 nm [9]; the Bohr radius of photo-excited electron-hole pairs in semiconductors is ~1-10 nm [10]; and the 1-100 nm dimension is the range over which molecules assemble into nucleic acids and proteins [11]. Nanostructures on this size scale provide a unique technology to determine many critical structure/function relationships of biological molecules at the cellular level without introducing substantial interference. Advances in nanotechnology have developed at several stages: materials, devices, and systems. A decade ago, extensive research has focused on the development of various methods to precisely control the synthesis of nanomaterials. Therefore, many differ...

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Binding of an Anti-Fullerene IgG Monoclonal Antibody to Single Wall Carbon Nanotubes

Cited by 204 publications

References 13 publications

Carbon Nanotube−Metal Cluster Composites: A New Road to Chemical Sensors?

Carbon Nanotube−Metal Cluster Composites: A New Road to Chemical Sensors?

Carbon Nanotubes - A Potential Material for Affinity Biosensors

Nano-bio interfaces probed by advanced optical spectroscopy: From model system studies to optical biosensors

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