Binding of a Polycyclic Hydrocarbon to Mouse Skin Proteins

Abstract

The tritium content of the L-and K-region of commercial available tritiated 1,2,5,6-Dibenzanthracene was measured and compared with the 3 H-release after binding of the compound to mouse skin proteins. The results exclude an addition reaction to the K-and L-region and favour a substitution reaction at one C-atom.According to the P u 11 m a n's theory the interaction of carcinogenic hydrocarbons with tissue consticuents should occur via an addition reaction at the K-region (Fig. 1) of the hydrocarbon 1 .