Abstract:Microtubules (MTs) and their associated proteins are essential for many cellular processes, including maintenance of cellular structure, cell motility, cell division, and intracellular transport. Kinesin superfamily (KIFs) proteins are molecular motors that directionally transport organelles and cargos along MTs. As the first-discovered kinesins, the Kinesin-1 superfamily (KIF5s) is a group of highly processive motor proteins. Despite KIF5B's importance in cellular health, atomic level insight to the structur… Show more
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