Binding interactions of anesthetic drug with surface active ionic liquid

Pal, Amalendu; Yadav, Abhay Singh

doi:10.1016/j.molliq.2016.07.076

Cited by 46 publications

(29 citation statements)

References 39 publications

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“…Nevertheless, it is necessary to consider that the APIs evaluated demonstrated an important role in modulating the IL–IL association properties. These results corroborate with the recent investigation by Pal and Yadav, 16 which showed the pivotal role of lidocaine hydrochloride in modulating aggregation properties of monocationic ILs [DoDec(MIM)][Cl] and [TetDec(MIM)][Cl] (in which DoDec and TetDec correspond to the alkyl chain of 12 and 14 carbons, respectively). However, this interaction can be quite different because this system is composed of a mixture of salts (both IL and API are charged).…”

Section: Resultssupporting

confidence: 92%

“…In this case, the presence of a benzyl unit bonded to the imidazolium ring can promote an additional steric hindrance between the IL monomers and API molecules at aggregate interfaces, thus slowing the aggregation process. Pal et al 16 recently evaluated binding interactions of the anesthetic drug lidocaine hydrochloride with SAILs and found that cac decreases as the concentration of the drug increases. The authors attributed this cac reduction to the presence of cation−π interactions between the imidazolium ring of the SAIL and the drug molecules.…”

Section: Resultsmentioning

confidence: 99%

“…11,27 Furthermore, a broad range of studies on interactions between IL and APIs are carried out with ionic APIs, in which the association with ILs are mostly favored by ionic interactions. 10,11,16…”

Section: Introductionmentioning

confidence: 99%

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Heteroassembly Ability of Dicationic Ionic Liquids and Neutral Active Pharmaceutical Ingredients

et al. 2018

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Extensive investigation of interactions and aggregation properties of IL + API systems is necessary to apply ionic liquids (ILs) with different hydrophobic characteristics to drug delivery or in active pharmaceutical ingredient (API) formulations. Therefore, this study aims to investigate the heteroassembly between dicationic ILs ([BisOct(MIM) 2 ][2X], in which X is Br or BF 4 , and [BisOct(BnIM) 2 ][2Br]), both in the absence and the presence of neutral APIs (salicylic acid, ibuprofen, and paracetamol) with different functional groups. Isothermal titration calorimetry results demonstrate that IL–API associations occur at very low concentrations of IL. These results were reinforced by electrospray ionization mass spectrometry with variable collision-induced dissociation, in which the IL dication interactions with APIs were detected. The strength of the dication–API interaction was determined from E cm,1/2 data. The aggregation parameters (cac, Δ G agg ° , and K ) between ILs and APIs were evaluated by conductivity. The 1 H NMR data showed that differences in chemical shifts provided relevant insights about interaction sites in both components.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

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Heteroassembly Ability of Dicationic Ionic Liquids and Neutral Active Pharmaceutical Ingredients

et al. 2018

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“…Thus, the value of CMC can be obtained at the point of intersection obtained by extrapolating the regression lines obtained in the plot of surface tension vs. logarithm of surfactant concentration. Also, various surface-active parameters can be determined by employing the CMC value obtained (Mahajan and Sharma, 2011 ; Pal and Yadav, 2016 ; Zhao et al, 2017 ; Panda et al, 2018 ; Liao et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Scrutinizing Self-Assembly, Surface Activity and Aggregation Behavior of Mixtures of Imidazolium Based Ionic Liquids and Surfactants: A Comprehensive Review

Kumar

Kaur

2021

Front. Chem.

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The desire of improving various processes like enhanced oil recovery (EOR), water treatment technologies, biomass extraction, organic synthesis, carbon capture etc. in which conventional surfactants have been traditionally utilized; prompted various researchers to explore the self-assembly and aggregation behavior of different kinds of surface-active molecules. Ionic liquids (ILs) with long alkyl chain present in their structure constitute the advantageous properties of surfactant and ILs, hence termed as surface-active ionic liquids (SAILs). The addition of ILs and SAILs significantly influence the surface-activity and aggregation behavior of industrially useful conventional surfactants. After a brief review of ILs, SAILs and surfactants, the prime focus is made on analyzing the self-assembly of SAILs and the mixed micellization behavior of conventional surfactants with different ILs.

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“…The interactions phenomena of the imidazolium ILs with the amino acids have further been further investigated by fluorescence technique [40]. The imidazolium ring of the ILs is responsible for giving significant emission spectra in fluorescence.…”

Section: Steady State Fluorescence Studymentioning

confidence: 99%

Exploring Diverse Interactions of Some Surface-Active Ionic Liquids with Amino Acids Prevalent in Aqueous Environments by Physicochemical Contrivance

Majumder¹,

Kundu²,

Ghosh³

et al. 2019

JACS

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Molecular interactions of two (ILS) [BMIM][C8SO4] and [MOIM]Cl with amino acids (AA) (AA= L-tyr, Lphe) in aqueous medium have been investigated by molar conductivities (Ʌ) at three different temperatures. Spectroscopic studies have been performed to investigate the association behavior between the ILs and the selected amino acids and the spontaneity of this process. The 1 H NMR spectroscopy has also been carried out to expose the change in electronic conditions of various protons of ILs in the presence of different amino acids. All the results have been interpreted on the light of possible molecular interactions operating in the ternary system and varies in the order of ([BMIM][C8SO4] + L-tyr)> ([MOIM]Cl + L-tyr)> ([BMIM][C8SO4] + L-phe)> ([MOIM]Cl + L-phe) in water. The obtained experimental parameters will be extremely supportive to understand the mixing effect and other complicated biological process between amino acids and the chosen ionic liquids.

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Binding interactions of anesthetic drug with surface active ionic liquid

Cited by 46 publications

References 39 publications

Heteroassembly Ability of Dicationic Ionic Liquids and Neutral Active Pharmaceutical Ingredients

Heteroassembly Ability of Dicationic Ionic Liquids and Neutral Active Pharmaceutical Ingredients

Scrutinizing Self-Assembly, Surface Activity and Aggregation Behavior of Mixtures of Imidazolium Based Ionic Liquids and Surfactants: A Comprehensive Review

Exploring Diverse Interactions of Some Surface-Active Ionic Liquids with Amino Acids Prevalent in Aqueous Environments by Physicochemical Contrivance

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