Binding Characteristics and Vascular Effects of Various Angiotensin II Antagonists

Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1‐receptor subtype

“…An international committee (Bumpus et al, 1991) has proposed the designations AT, for the receptor subtype sensitive to DuP 753 (losartan), and AT2 for the subtype sensitive to PD 123177 (Blankley et al, 1991) and CGP 42 112 A (Whitebread et al, 1989;. The AT,-receptor subtype is the one responsible for the well-known effects of AII, such as vasoconstriction, aldosterone and adrenaline release, water intake, and cellular proliferation (Criscione et al, 1990;Herblin et al, 1991;Chiu et al, 1991c;Smith et al, 1992), whereas the pathophysiological role of the AT2-receptor subtype is not yet well understood (Criscione et al, 1990;Herblin et al, 1991;Dudley et al, 1991;Timmermans et al, 1991c). Recent reports, however, indicate that the AT2 receptor does not interact with guanine-nucleotidebinding protein , but may stimulate tyrosine phosphatase activity .…”

Detection of Fetal Cells in the Maternal Kidney during Gestation in the Mouse

“…Fetal cells might infiltrate the maternal kidney and participate in renal repair. AT1 is the predominant AT subtype detected at multiple sites within the vascular system, liver, kidney, and adrenal cortex (Criscione et al 1990;Zhuo et al 1992;Miyata et al 1999). AT1 is known to mediate vasoconstriction (Criscione et al 1990;Sasaki et al 1991;Franco et al 2001) and mesangial fibrosis, leading to tubular cell hypertrophy and progressive glomerulosclerosis activation (Ardaillou 1999).…”

“…AT1 is the predominant AT subtype detected at multiple sites within the vascular system, liver, kidney, and adrenal cortex (Criscione et al 1990;Zhuo et al 1992;Miyata et al 1999). AT1 is known to mediate vasoconstriction (Criscione et al 1990;Sasaki et al 1991;Franco et al 2001) and mesangial fibrosis, leading to tubular cell hypertrophy and progressive glomerulosclerosis activation (Ardaillou 1999). In contrast, AT2 exhibits limited expression in the adult, but is abundantly expressed during fetal development (Shanmugam et al 1995;Shanmugam and Sandberg 1996;Ruan et al 1997), where it antagonizes AT1 activity (Siragy and Carey 1997;Horiuchi et al 1999;Yamada et al 1999;Gallinat et al 2000).…”

“…Fetal cells expressing AT2 may therefore be involved in the regulation of vasoreactivity, especially in the maternal kidney. In contrast, angiotensin II receptor subtype 1 (AT1) is predominantly located in the vascular system, liver, kidney, and adrenal cortex, and it mediates vasoconstriction, aldosterone secretion, and the renal sodium resorption induced by angiotensin II (Criscione et al 1990;Sasaki et al 1991;Ruan et al 1997).…”

Les récepteurs de l'angiotensine II dans le placenta humain sont de type AT1

“…Une certaine confusion existe dans la littérature (Chiu et al, 1989;Chang et (Criscione et al, 1990;de Gasparo et al, 1990 (Cooke et al, 1981;Wilkes et al, 1985; Kurauchi et al, 1990) …”