“…The self-assembly of micro-and nano-size particles mediated by linkers has been the focus of extensive experimental, 1-9 theoretical [10][11][12] and simulation 4,10,11,[13][14][15][16][17] studies in recent years, since the addition of a second species provides extra control of the aggregation process. Indeed the linkers to particles ratio, 1,4,6,8,9 the strength of the linker-particle interactions, 5,7 and the maximum number of linkers that can bond to one particle, 7,8 may be used to tune the stability of the mixture, the extent and topology of the assembled structures, the equilibrium phase behavior and the rheological properties of the system. 3,18 The linker-particle interactions are most often engineered using complementary biological macromolecules, such as complementary DNA strands 3,8 or streptavidin and biotin.…”