Binding and Transfer of Human Immunodeficiency Virus by DC-SIGN⁺Cells in Human Rectal Mucosa

HIV-1 Transmission by Dendritic Cell-specific ICAM-3-grabbing Nonintegrin (DC-SIGN) Is Regulated by Determinants in the Carbohydrate Recognition Domain That Are Absent in Liver/Lymph Node-SIGN (L-SIGN)

“…ϩ T cells (6), and up to 90% of HIV-1 binding to human mucosal tissue explants has been attributed to DC-SIGN-expressing cells (31). DC-SIGN expressed by in vitro differentiated immature monocyte-derived DCs confers signifi-cant HIV-1 binding and transmission by these cells (32)(33)(34), which can be recapitulated through ectopic expression of DC-SIGN in Raji B cells (35).…”

Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1

“…Most of these experiments have been carried out by using HIV-1 glycoprotein gp120. Experiments using HIV-1 particles, rather than recombinant gp120, have suggested that other unknown receptors are involved (13)(14)(15).…”

“…HIV-1 binds to DCs. However, the identity of the HIV-1 receptors on DCs is currently under intense debate (11)(12)(13)(14)(15). Different receptors have been demonstrated to interact with HIV-1 on DCs, such as the C-type lectin DC-SIGN (11,16), the mannose receptor (17), langerin (18), and CD4 (17).…”

Morphometric analysis of dendritic cells from anal mucosa of HIV-positive patients and the relation to intraepithelial lesions and cancer seen at a tertiary health institution in Brazil

“…A difference was present in the CD1a+ DC when comparing the whole HIV-negative group (median of 3.75, n=46) with the whole HIV-positive group (median of 2.54, n=51) (p=0.018) (n=97) ( Table 1). The study of the distribution of DC-SIGN in DC anal or rectal mucosa has previously been performed by other authors [15][16][17] .…”