Binding ability of sodium valproate with cationic surfactants and effect on micellization: calorimetric, surface tension, light scattering and spectroscopic approach

Kaur, Rupinder; Banipal, Parampaul K.; Banipal, Tarlok S.

doi:10.1007/s10973-019-09036-4

Cited by 6 publications

(2 citation statements)

References 49 publications

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“…Data obtained by the ITC measurements were analyzed by assuming the formation of a 1:1 inclusion complex between TMZ and SC4OH; other models were tested but were always rejected by the program. A model that assumes a 1:1 species between the drug and the micellar aggregate formed by SC4OC6 (both in the presence and in the absence of curcumin) was also employed, as previously reported by us [59] and in line with many research groups that used the "one site" binding model for the refinement of the thermodynamic parameters of similar systems [60][61][62][63][64].…”

Section: Solution Thermodynamics Of the Sc4oc6/tmz And Sc4oc6/cur/tmz...mentioning

confidence: 99%

Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium

et al. 2021

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The co-delivery of anticancer drugs into tumor cells by a nanocarrier may provide a new paradigm in chemotherapy. Temozolomide and curcumin are anticancer drugs with a synergistic effect in the treatment of multiform glioblastoma. In this study, the entrapment and co-entrapment of temozolomide and curcumin in a p-sulfonato-calix[4]arene nanoparticle was investigated by NMR spectroscopy, UV-vis spectrophotometry, isothermal titration calorimetry, and dynamic light scattering. Critical micellar concentration, nanoparticle size, zeta potential, drug loading percentage, and thermodynamic parameters were all consistent with a drug delivery system. Our data showed that temozolomide is hosted in the cavity of the calix[4]arene building blocks while curcumin is entrapped within the nanoparticle. Isothermal titration calorimetry evidenced that drug complexation and entrapment are entropy driven processes. The loading in the calixarene-based nanocontainer enhanced the solubility and half-life of both drugs, whose medicinal efficacy is affected by low solubility and rapid degradation. The calixarene-based nanocontainer appears to be a promising new candidate for nanocarrier-based drug combination therapy for glioblastoma.

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Section: Solution Thermodynamics Of the Sc4oc6/tmz And Sc4oc6/cur/tmz...mentioning

confidence: 99%

Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium

et al. 2021

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“…Moreover, due to its properties, valproic acid is effective against several types of cancer, including neuroblastoma [36,37], since it impairs growth and induces differentiation in human neuroblastoma cells in harmless concentrations [35,37]. Therefore, there is currently a great interest in evaluating the physicochemical interactions of ionic liquids and valproate [38][39][40][41][42]. However, the biological activity and toxicity of these mixtures have never been investigated.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity of Ionic Liquids Based on Valproate in SH-SY5Y Human Neuroblastoma Cell Line

Dias

Ferraz

Costa‐Rodrigues

et al. 2022

Future Pharmacology

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The search for alternative and effective therapies to fight cancer is one of the main goals of the pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. The goal of this study was to synthesize and evaluate the bioactivity of different ILs coupled with the active pharmaceutical ingredient (API) valproate (VPA) as an antitumor agent. The toxicity of the prepared ionic liquids was evaluated by the MTT cell metabolic assay in human neuroblastoma SH-SY5Y and human primary Gingival Fibroblast (GF) cell lines, in which they showed inhibitory effects during the study period. In addition, low cytotoxicity against GF cell lines was observed, suggesting that these compounds are not toxic to human cell lines. [C2OHDMiM][VPA] demonstrated an outstanding antitumor activity against SH-SY5Y and lower activity against the non-neoplastic GF line. The herein assessed compounds played an important role in the modulation of the signaling pathways involved in the cellular behavior. This work also highlights the potential of these ILs-API as possible antitumor agents.

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Binding studies of dopamine HCl drug with the mixed {sodium bis(2-ethylhexyl) sulfosuccinate + sodium dodecylsulfate} micelles: Physicochemical, spectroscopic, calorimetric and computational approach

Sohal

Kaur

Singh

et al. 2022

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Binding ability of sodium valproate with cationic surfactants and effect on micellization: calorimetric, surface tension, light scattering and spectroscopic approach

Cited by 6 publications

References 49 publications

Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium

Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium

Bioactivity of Ionic Liquids Based on Valproate in SH-SY5Y Human Neuroblastoma Cell Line

Binding studies of dopamine HCl drug with the mixed {sodium bis(2-ethylhexyl) sulfosuccinate + sodium dodecylsulfate} micelles: Physicochemical, spectroscopic, calorimetric and computational approach

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