Binaural interaction in the human auditory cortex revealed by neuromagnetic frequency tagging: no effect of stimulus intensity

Kaneko, Ken‐ichi; Fujiki, Nobuya; Hari, Riitta

doi:10.1016/s0378-5955(03)00186-2

Cited by 38 publications

(62 citation statements)

References 18 publications

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“…2 B). The tagged auditory-cortex responses were selectively extracted from each hemisphere with magnetoencephalography with a method previously developed in our laboratory (Fujiki et al, 2002;Kaneko et al, 2003). By means of the modulation frequencies, MEG signals for the left and right-ear inputs of the binaural stimuli can be separated from each other and then compared with the monaural responses to quantify the binaural suppression.…”

Section: Methodsmentioning

confidence: 99%

“…The stimulation and analysis were based on previous nonclinical studies of frequency-tagged auditory inputs (Fujiki et al, 2002;Kaneko et al, 2003). We delivered, via plastic tubes and earpieces, continuous 1 kHz tones that were amplitude modulated with 100% depth at 41.1 Hz in the left ear and at 39.1 Hz in the right ear (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Sound intensity was set at the loudest but still comfortable listening level (60 -75 dB above the individual hearing threshold; mean Ϯ SEM, 70 Ϯ 1.5 for ROBO1 group and 71 Ϯ 1.4 for control subjects); intensity changes have no effect on the magnitude of binaural interaction within the range of 45-75 dB sensation level (Kaneko et al, 2003) and thus to the focus of this study. The subjects were instructed to keep their eyes open during the experiment.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, the auditory cortices of each hemisphere receive input from both ears. Cortical steady-state responses to sounds from one ear are weaker during binaural than monaural listening, indicating binaural suppressive interaction (Fujiki et al, 2002;Kaneko et al, 2003). The suppression is stronger for ipsilateral than contralateral sounds and requires convergence of the inputs from both ears somewhere in the auditory pathways.…”

Section: Introductionmentioning

confidence: 99%

“…We studied binaural suppression-and thereby indirectly the strength of crossing in auditory pathways-in individuals with the ROBO1 gene defect by "frequency-tagging" magnetoencephalographic (MEG) steady-state responses, a method used previously in nonclinical studies (Fujiki et al, 2002;Kaneko et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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HumanROBO1Regulates Interaural Interaction in Auditory Pathways

et al. 2012

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In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left-and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dosedependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HumanROBO1Regulates Interaural Interaction in Auditory Pathways

et al. 2012

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Effect of sequential comparison on active processing of sound duration

Angenstein

Brechmann

2017

Hum. Brain Mapp.

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Previous studies on active duration processing on sounds showed opposing results regarding the predominant involvement of the left or right hemisphere. Duration of an acoustic event is normally judged relative to other sounds. This requires sequential comparison as auditory events unfold over time. We hypothesized that increasing the demand on sequential comparison in a task increases the involvement of the left auditory cortex. With the current fMRI study, we investigated the effect of sequential comparison in active duration discrimination by comparing a categorical with a comparative task. During the categorical task, the participant had to categorize the tones according to their duration (short vs long). During the comparative task, they had to decide for each tone whether its length matched the tone presented before. We used the contralateral noise procedure to reveal the degree of participation of the left and right auditory cortex during these tasks. We found that both tasks more strongly involve the left than the right auditory cortex. Furthermore, the left auditory cortex was more strongly involved during comparison than during categorization. Together with previous studies, this suggests that additional demand for sequential comparison during processing of different basic acoustic parameters leads to an increased recruitment of the left auditory cortex. In addition, the comparison task more strongly involved several brain areas outside the auditory cortex, which may also be related to the demand for additional cognitive resources as compared to the more efficient categorization of sounds. Hum Brain Mapp 38:4459-4469, 2017. © 2017 Wiley Periodicals, Inc.

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The impact of task difficulty on the lateralization of processing in the human auditory cortex

Brechmann

Angenstein

2019

Human Brain Mapping

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Perception of complex auditory stimuli like speech requires the simultaneous processing of different fundamental acoustic parameters. The contribution of left and right auditory cortex (AC) in the processing of these parameters differs. In addition, activity within the AC can vary positively or negatively with task performance depending on the type of task. This might affect the allocation of processing to the left and right AC. Here we studied with functional magnetic resonance imaging the impact of task difficulty on the degree of involvement of the left and right AC in two tasks that have previously been shown to differ in hemispheric involvement: categorization and sequential comparison of the direction of frequency modulations (FM). Task difficulty was manipulated by changing the speed of modulation and by that the frequency range covered by the FM. To study the impact of task‐difficulty despite covarying the stimulus parameters, we utilized the contralateral noise procedure that allows comparing AC activation unconfounded by bottom‐up driven activity. The easiest conditions confirmed the known right AC involvement during the categorization task and the left AC involvement during the comparison task. The involvement of the right AC increased with increasing task difficulty for both tasks presumably due to the common task component of categorizing FM direction. The involvement of left AC varied with task difficulty depending on the task. Thus, task difficulty has a strong impact on lateralized processing in AC. This connection must be taken into account when interpreting future results on lateralized processing in the AC.

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Binaural interaction in the human auditory cortex revealed by neuromagnetic frequency tagging: no effect of stimulus intensity

Cited by 38 publications

References 18 publications

HumanROBO1Regulates Interaural Interaction in Auditory Pathways

HumanROBO1Regulates Interaural Interaction in Auditory Pathways

Effect of sequential comparison on active processing of sound duration

The impact of task difficulty on the lateralization of processing in the human auditory cortex

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