Binary technologies of malignant tumors radiotherapy

Abstract

Binary radiotherapy (BRT) approach for curing malignant tumors is described in the paper. Two main modalities of BRT, i.e. Neutron Capture Therapy and Contrast Enhanced Radiotherapy are being described and compared. Physics of BRT practical implementation is discussed. Clinical efficacy of BRT in treating brain tumors and head and neck cancer as well as pharmacological challenges and achievements are being reviewed.

Design, synthesis and antitumor activity evaluation in vitro of 4,6,7-trisubstituted quinazoline derivatives containing acrylamide moiety

“…white yellow solid, yield 79.3%. 1 H NMR (400 MHz, DMSO-d 6 ) δ (ppm) 10.22 (s,1H),9.07 (s,1H),7.70 (s,1H),3H),7.50 (s,1H),7.35 (t,J = 8.1 Hz,1H),7.25 (s,1H),7.11 (d,J = 3.1 Hz,1H),7.04 (dd,J = 7.9,2.1 Hz,1H),6.92 (m,1H),6.33 (dd,J = 16.9,10.1 Hz,1H),6.22 (dd,J = 16.9,2.0 Hz, 1H), 5.75 (dd, J = 10.0, 2.2 Hz, 1H), 5.10 (s, 2H), 4.02 (s, 3H), 3.74 (s, 3H). 13 C NMR (101 MHz, DMSO-d 6 ) δ (ppm) 165.54, 163.24, 158.80, 156.32, 153.38, 150.42, 149.29, 140.81, 139.93, 135.71, 133.36, 131.54, 129.64, 129.45, 127.21, 122.27, 118.06, 116.22, 115.87, 115.60, 112.77, 107.10, 103.61, 69.92, 56.56, 55.43…”

“…The data showed that cancer accounted for 21% of the total human deaths, and was the second leading cause of death after cardiovascular diseases [1]. Surgical treatment and non-surgical treatment are still the main treatment methods for malignant tumors, while non-surgical treatment includes various treatment methods, such as common radiation therapy [2], chemotherapy [3,4], and targeted therapy [5,6].…”

A Laser Synthesis Route to Boron‐Doped Gold Nanoparticles Designed for X‐Ray Radiotherapy and Boron Neutron Capture Therapy Assisted by CT Imaging

“…XRT is used in more than 50 % of cancer treatments, especially for treating primary non-metastasized solid tumors. [19,39] Nothing is known about the radiobiological effects of combined radiotherapy with a combined radiosensitizer for XRT and BNCT, which have different depth dose profiles [40] and penetration depth of emitted particles (hundreds of nm for Auger and Compton electrons from XRT versus microns for alpha particles from BNCT). [4,41] Besides, BNCT is promising for the treatment of hypoxic tumor regions because the alpha particles have high linear energy transfer (LET) and induce direct damage in DNA, causing irreparable double-strand breaks, whereas the low-LET particles produced by XRT induce mostly reparable DNA singlestrand breaks by indirect damage through generation of reactive oxygen species (ROS), resulting more effective on nonhypoxic tumor regions.…”

“…XRT is used in more than 50 % of cancer treatments, especially for treating primary non‐metastasized solid tumors. [ 19,39 ] Nothing is known about the radiobiological effects of combined radiotherapy with a combined radiosensitizer for XRT and BNCT, which have different depth dose profiles [ 40 ] and penetration depth of emitted particles (hundreds of nm for Auger and Compton electrons from XRT versus microns for alpha particles from BNCT). [ 4,41 ]…”