Binary polymeric amorphous carvedilol solid dispersions: In vitro and in vivo characterization

Krstić, Marko; Manić, Luka; Martić, Nikola; Vasiljević, Dragana; Mračević, Svetlana Đogo; Vukmirović, Saša; Rašković, Aleksandar

doi:10.1016/j.ejps.2020.105343

Cited by 33 publications

(29 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once a poorly water-soluble drug is dispersed in a polymer for SD formation, a weak physical bond may be formed between these components to modulate drug release ( Figure 2 ). Weak physical bonds (formed by non-covalent interactions) such as hydrogen bonds, ionic bonds, van der Waals, dipole-dipole interactions and acid-base interactions are common interactions occurred between components in SDs [ 26 , 34 , 35 , 36 , 37 , 38 ]. Among them, hydrogen bonding formation is typically observed in SDs [ 39 , 40 , 41 , 42 ].…”

Section: How Molecular Interactions Are Important In Sdsmentioning

confidence: 99%

“…Figure 3 illustrates different IR methods and their detection of molecular interactions in SDs. In SD studies, IR is a common technique for the determination of molecular interactions between components, particularly those between a drug and an SD component [ 17 , 26 , 52 , 53 , 54 , 55 , 56 ]. Indeed, the use of IR was recommended in early studies on SD to identify the interaction between a model drug and a polymer.…”

Section: Spectroscopic Techniques Used In the Investigation Of Molmentioning

confidence: 99%

“…Both traditional approaches (e.g., polymorphs, prodrugs, salt formation, and solid dispersions (SDs)) and current nanotechnologies (e.g., solid lipid nanoparticles, nanoprecipitations, and nanoemulsions) have contributed useful techniques and strategies for the development of formulations of poorly water-soluble drugs [ 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Among them, the development of SDs (even in combination with nanotechnology) is still being heavily investigated to improve the drug solubility, dissolution rate and stability of poorly water-soluble drugs [ 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs

Tran

2020

Pharmaceutics

View full text Add to dashboard Cite

Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.

show abstract

Section: How Molecular Interactions Are Important In Sdsmentioning

confidence: 99%

Section: Spectroscopic Techniques Used In the Investigation Of Molmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs

Tran

2020

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…All three prepared solid dispersions showed an improvement in the percentage of the released drug after 60 min for both active substances, compared to the pure APIs. The reason for such improvements could be because APIs in SD are surrounded by the molecules of the hydrophilic polymers, which improves wetting and dissolution [19,31,32].…”

Section: In Vitro Dissolution Datamentioning

confidence: 99%

“…A solid dispersion is a dispersion of one or more active ingredients in a hydrophilic inert carrier matrix at solid state. Two basic procedures used to prepare solid dispersions are solvent evaporation and melting methods [15,16,18,19].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Dissolution Study of Acetylsalicylic Acid and Clopidogrel Bisulfate Solid Dispersions: Validation of the RP-HPLC Method for Simultaneous Analysis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Solid dispersions were prepared via a solvent evaporation method, employing ethanol (96%, v/v) as solvent, with three different polymers as carrier: povidone, copovidone, and poloxamer 407. Previously developed reversed-phase HPLC (RP-HPLC) methods were modified and used for the simultaneous determination of acetylsalicylic acid and clopidogrel bisulfate and after release from solid dispersions. Chromatography was carried out on a C-18 column, with a mobile phase of acetonitrile–methanol–phosphate buffer pH 3.0, UV detection at 240 nm, and a run time of 6 min. The method was validated according to International Conference of Harmonisation guidelines and validation included specificity, accuracy, precision, linearity, robustness, limit of detection (LOD), and limit of quantification (LOQ). The method is specific for determination of acetylsalicylic acid and clopidogrel bisulfate. The linearity was provided in the concentration range 0.0275–0.1375 mg/mL for acetylsalicylic acid and 0.0200–0.1000 mg/mL for clopidogrel bisulfate, with a correlation coefficient (R2 value) of 0.9999 for both active pharmaceutical ingredients (APIs). Accuracy was confirmed by calculated recoveries for acetylsalicylic acid (98.6–101.0%) and clopidogrel bisulfate (100.0–101.6%). The intra-day and the inter-day precision-calculated relative standard deviations are less than 1%, which indicates high precision of the method. The limits of detection and quantification for acetylsalicylic acid were 0.0004 and 0.0012 mg/mL, and for clopidogrel bisulfate 0.0002 mg/mL and 0.0007 mg/mL, respectively. Small variations in chromatographic conditions did not significantly affect qualitative and quantitative system responses, which proved robustness of method. The proposed RP-HPLC method was applied for simultaneous determination of clopidogrel bisulfate and acetylsalicylic acid from solid dispersions.

show abstract

Advances in polymer‐based cell encapsulation and its applications in tissue repair

Xia

Chen

2023

Biotechnology Progress

View full text Add to dashboard Cite

Cell microencapsulation is a more widely accepted area of biological encapsulation.In most cases, it involves fixing cells in polymer scaffolds or semi-permeable hydrogel capsules, providing the environment for protecting cells, allowing the exchange of nutrients and oxygen, and protecting cells against the attack of the host immune system by preventing the entry of antibodies and cytotoxic immune cells. Hydrogel encapsulation provides a three-dimensional (3D) environment similar to that experienced in vivo, so it can maintain normal cellular functions to produce tissues similar to those in vivo. Embedded cells can be genetically modified to release specific therapeutic products directly at the target site, thereby eliminating the side effects of systemic treatments. Cellular microcarriers need to meet many extremely high standards regarding their biocompatibility, cytocompatibility, immunoseparation capacity, transport, mechanical, and chemical properties. In this article, we discuss the biopolymer gels used in tissue engineering applications and the brief introduction of cell encapsulation for therapeutic protein production. Also, we review polymer biomaterials and methods for preparing cell microcarriers for biomedical applications. At the same time, in order to improve the application performance of cell microcarriers in vivo, we also summarize the main limitations and improvement strategies of cell encapsulation. Finally, the main applications of polymer cell microcarriers in regenerative medicine are summarized.

show abstract

Binary polymeric amorphous carvedilol solid dispersions: In vitro and in vivo characterization

Cited by 33 publications

References 50 publications

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs

In Vitro Dissolution Study of Acetylsalicylic Acid and Clopidogrel Bisulfate Solid Dispersions: Validation of the RP-HPLC Method for Simultaneous Analysis

Advances in polymer‐based cell encapsulation and its applications in tissue repair

Contact Info

Product

Resources

About