The next generation of gravitational-wave detectors, conceived to begin operations in the 2030s, will probe fundamental physics with exquisite sensitivity. These observations will measure the equation of state of dense nuclear matter in the most extreme environments in the universe, reveal with exquisite fidelity the nonlinear dynamics of warped spacetime, put general relativity to the strictest test, and perhaps use black holes as cosmic particle detectors. Achieving each of these goals will require a new generation of numerical relativity simulations that will run at scale on the supercomputers of the 2030s to achieve the necessary accuracy, which far exceeds the capabilities of numerical relativity and high-performance computing infrastructures available today. Contents 1 Motivation 2 Gravitational waveform modeling 3 Nuclear physics and neutron stars 4 Modeling high-precision gravitational-wave observations 5 Testing gravity in the nonlinear regime 6 Black holes as cosmic particle detectors