Binary Isobaric Vapor–Liquid Equilibrium for the System of 1-Phenylethanol + Ethyl Butyrate + Ethanol +1-Phenylethyl Butyrate at 101.3 kPa

Abstract

The enzymatic reaction−distillation coupling process is a promising technology to realize the chiral resolution of (R/S)-1-phenylethanol with ethyl butyrate and ethanol as acyl donor and byproduct, respectively. In order to design such a coupling process, the vapor−liquid equilibrium (VLE) data are necessary. However, these data were incomplete in literatures. In this work, the isobaric VLE experiments were conducted at 101.3 kPa for the binary systems of 1-phenylethanol + ethyl butyrate, 1-phenylethanol + ethanol, 1-phenylethyl butyrate + ethyl butyrate, 1phenylethyl butyrate + ethanol, and 1-phenylethyl butyrate +1-pheny ethanol. Additionally, the saturated vapor pressure of 1-phenylethyl butyrate was measured in the temperature range 420−500 K and correlated with the Antoine equation. Both the Non-Random Two Liquid (NRTL) and Wilson models were used for the correlation of experimental VLE data. Both models showed satisfactory accuracy, although the Wilson model performed slightly better than the NRTL model. This work would provide important thermodynamic information for the design of enzymatic reaction−distillation coupling process to realize the chiral resolution of (R/S)-1-phenylethanol.

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“…This is almost the same as the experimental instruments and procedures used in the references, − which also shows the rationality of the experimental method.…”

Unraveling the reaction route and kinetics of 3‐methyl‐3‐penten‐2‐one synthesis for synthetic ketone fragrances

“…[19][20][21][22][23][24][25] Generally, detailed reaction kinetics and thermodynamics data are necessary to choose feasible PI technologies for a certain reaction. [26][27][28][29][30] If the main reaction is accompanied by several complex side reactions, the detailed reaction routes must be also provided. That is because the side reactions might be enhanced or suppressed by using a certain process intensification method.…”

“…There are several PI technologies that could be considered, such as reactive distillation, micro‐reactors, high gravity rotating packed bed reactor, etc 19–25 . Generally, detailed reaction kinetics and thermodynamics data are necessary to choose feasible PI technologies for a certain reaction 26–30 . If the main reaction is accompanied by several complex side reactions, the detailed reaction routes must be also provided.…”