Binary ethosomes-based transdermal patches assisted by metal microneedles significantly improve the bioavailability of carvedilol

Jiang, Di; Jiang, Yuxin; Wang, Kaili; Wang, Zhe; Pei, Yanbo; Wu, Jinglei; He, Chuanglong; Mo, Xiumei; Wang, Hongsheng

doi:10.1016/j.jddst.2022.103498

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…The reported study indicates that MN-based transdermal drug delivery patches significantly reduced the fluctuation of carvedilol concentration in plasma, thus reducing blood pressure for longer. The MN transdermal drug delivery patch showed a promising prospect for improving the bioavailability of carvedilol as compared to the oral route for treating chronic diseases such as hypertension [ 156 ].…”

Section: Fabrication and Current Status Of Microneedlesmentioning

confidence: 99%

Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review

et al. 2023

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One of the most cutting-edge, effective, and least invasive pharmaceutical innovations is the utilization of microneedles (MNs) for drug delivery, patient monitoring, diagnostics, medicine or vaccine delivery, and other medical procedures (e.g., intradermal vaccination, allergy testing, dermatology, and blood sampling). The MN-based system offers many advantages, such as minimal cost, high medical effectiveness, comparatively good safety, and painless drug application. Drug delivery through MNs can possibly be viewed as a viable instrument for various macromolecules (e.g., proteins, peptides, and nucleic acids) that are not efficiently administered through traditional approaches. This review article provides an overview of MN-based research in the transdermal delivery of hypertensive drugs. The critical attributes of microneedles are discussed, including the mechanism of drug release, pharmacokinetics, fabrication techniques, therapeutic applications, and upcoming challenges. Furthermore, the therapeutic perspective and improved bioavailability of hypertensive drugs that are poorly aqueous-soluble are also discussed. This focused review provides an overview of reported studies and the recent progress of MN-based delivery of hypertensive drugs, paving the way for future pharmaceutical uses. As MN-based drug administration bypasses first-pass metabolism and the high variability in drug plasma levels, it has grown significantly more important for systemic therapy. In conclusion, MN-based drug delivery of hypertensive drugs for increasing bioavailability and patient compliance could support a new trend of hypertensive drug delivery and provide an alternative option, overcoming the restrictions of the current dosage forms.

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Section: Fabrication and Current Status Of Microneedlesmentioning

confidence: 99%

Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review

et al. 2023

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“…While some studies have investigated the potential of benzoyl peroxide ethosomes as a treatment for acne, more research is needed to confirm their safety and efficacy. 64 Furthermore, multidrug ethosomes can potentially enhance the efficacy of acne treatments and may be especially useful for patients with moderate to severe acne. 65 For example, a combination of tretinoin and benzoyl peroxide ethosomes can address multiple aspects of the acne pathogenesis.…”

Section: Ethosomes For Acnesmentioning

confidence: 99%

“…By incorporating benzoyl peroxide into ethosomes, the drug can be delivered directly to the sebaceous glands, leading to improved efficacy and reduced side effects. While some studies have investigated the potential of benzoyl peroxide ethosomes as a treatment for acne, more research is needed to confirm their safety and efficacy 64 …”

Section: Ethosomes Applications In Cosmetic Deliverymentioning

confidence: 99%

Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Abu‐Huwaij

Zidan

2023

J of Cosmetic Dermatology

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BackgroundIn a world where hair loss, acne, and skin whitening are common concerns, ethosomes emerge as a captivating breakthrough in cosmetic drug delivery.MethodThis review provides a comprehensive overview of the ethosomal system and assesses its potential as an effective nanocarrier for delivering active ingredients to the skin. The focus is on exploring their applications in various pathologies, particularly skin disorders such as acne, hair loss, and skin pigmentation.ResultsEthosomes are a novel type of vesicular nanocarrier composed of high concentrations of ethanol (20‐45%) and phospholipids. Their unique structure and composition make them an ideal choice for transporting active ingredients through the skin, offering targeted and effective treatment. The inclusion of ethanol in ethosomes' composition gives them distinctive properties, including flexibility, deformability, and stability, facilitating deep penetration into the skin and enhancing medication deposition. Moreover, ethosomes improved theoverall drug‐loading capacity, and specificity of target treatmentConclusionEthosomes represent a unique and suitable approach for delivering active cosmetic ingredients in the treatment of hair loss, acne, and skin whitening, presenting a versatile alternative to traditional dermal delivery systems. Despite the challenges associated with their complex preparation and sensitivity to temperature and humidity, the remarkable potential benefits of ethosomes cannot be ignored. Further research is crucial to unlock their full potential, understand their limitations, and refine their formulations and administration methods. Ethosomes hold the promise of transforming the way we address these cosmetic concerns, offering an exciting glimpse into the future of advanced skincare solutions.

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“…In recent years, there has been considerable interest in the use of ethosomes (Eths) for transdermal drug delivery. − Eths is a special liposome containing alcohols of low molecular weight with small particle size, high encapsulation rate, good stability, and excellent transdermal drug delivery performance . By modification with groups such as galactose or mannose on its surface, Eths can gain the ability to target DCs for antigen delivery to trigger immune response. , Silk fibroin is widely used in the biomedical field due to their excellent biocompatibility and physicochemical properties. , The silk fiber membrane (SFM) prepared by soaking silkworm cocoon shells (SCSs) in a ternary solution (CaCl 2 /ethanol/water) has shown huge application potential for its good mechanical and breathable moisturizing properties, as well as a simple, safe, and eco-friendly preparation process. − We recently reported a TCI system based on mannosylated chitosan (MC) modified Eths (Eths MC ) and silk fibrous membranes, which can effectively stimulate the immune response of the body and has the advantages of being easy to use, noninvasive, and simple to prepare. − …”

Section: Introductionmentioning

confidence: 99%

Noninvasive Transdermal Administration of mRNA Vaccines Encoding Multivalent Neoantigens Effectively Inhibits Melanoma Growth

Hou,

Wang,

Chen

et al. 2024

ACS Biomater. Sci. Eng.

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It is difficult to obtain specific tumor antigens, which is one of the main obstacles in the development of tumor vaccines. The vaccines containing multivalent antigens are thought to be more effective in antitumor therapy. In this study, a mRNA encoding three neoantigens of melanoma were prepared and encapsulated into the mannosylated chitosan-modified ethosomes (Eths MC ) to obtain a multivalent mRNA vaccine (MmRV) for transcutaneous immunization (TCI). MmRV can effectively induce maturation of dendritic cells, with a better performance than mRNA of a single neoantigen. TCI patches (TCIPs) loading MmRV or siRNA against PDL1 (siPDL1) were prepared and applied to the skin of melanoma-bearing mice. The results showed that TCIPs significantly increase the levels of TNF-α, IFN-γ, and IL-12 in both plasma and tumor tissues, inhibit tumor growth, as well as promote infiltration of CD 4+ and CD 8+ T cells in the tumor tissues. Furthermore, the combination of MmRV and siPDL1 showed much better antitumor effects than either monotherapy, suggesting a synergistic effect between the vaccine and PDL1 blocker. In addition, the treatment with the TCIPs did not cause damage to the skin, blood, and vital organs of the mice, showing good biosafety. To the best of our knowledge, this work is the first to construct a noninvasive TCI system containing MmRV and siPDL1, providing a convenient and promising approach for tumor treatment.

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Binary ethosomes-based transdermal patches assisted by metal microneedles significantly improve the bioavailability of carvedilol

Cited by 4 publications

References 43 publications

Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review

Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review

Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Noninvasive Transdermal Administration of mRNA Vaccines Encoding Multivalent Neoantigens Effectively Inhibits Melanoma Growth

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