“…There are several chemical ingredients in Binahong leaves, including flavonoids, oleanolic acid, protein, ascorbic acid (Ariani, Loho, & Durry, 2014), tannins, as well as triterpenoid, alkaloid, glycoside, and steroid saponins (Kurniawan, Carolia, & Pheilia, 2014). Binahong leaves also have antimicrobial, antiinflammatory, anti-parasitic, and anti-fever properties (Aditia et al, 2017). The ascorbic acid content in this plant is crucial for the activation of the prolyl hydroxylase enzyme, which supports the stage of hydroxylation in the formation of collagen so that the wound healing process can be accelerated (Ariani, Loho, & Durry, 2014).…”