Bimodal magnetic-fluorescent nanostructures for biomedical applications

Versatile electrostatic assembly of nanoparticles and polyelectrolytes: Coating, clustering and layer-by-layer processes

“…2a). Other clustering strategies allowing interchain associations were also attempted using magnetic NPs for the evaluation of bimodal magnetic-fluorescent contrast agents [28].…”

Magnetic polymeric nanoparticles functionalized by mannose‐rhodamine conjugate for detection of E. coli

“…After coating MPNPs with Rh B, the absolute zeta potentials of Rh B‐MPNPs were lower than those of MPNPs as shown in curve 5B. It appears that the presence of Rh B shielded the negative charge of the exposed AA or shifted the shear plane around the MPNPs …”

“…To understand interaction involved in the attachment of the fluorescent signaling unit to MPNP substrate, Rh B, a precursor for synthesis of mannose‐Rh conjugate, coated onto PS/DVB/AA MPNP was first examined. The driving force for the interaction between the MPNP and Rh B is an electrostatic interaction between negatively charged MPNP and positively charged Rh B molecule . The synthesized mannose‐Rh conjugate was subsequently produced and bound to MPNP via a hydrophobic interaction .…”

Assembly of near infra-red emitting upconverting nanoparticles and multiple Gd(iii)-chelates as a potential bimodal contrast agent for MRI and optical imaging

“…the ability of the CA to enhance the proton relaxation of water present in tissues is still relatively low, especially at higher magnetic field strengths. [31][32][33][34][35][36] Heteronuclear metal complexes combining the gadolinium(III)-entity that is responsible for the MRI signal and the luminescent metal for the optical signal have also been reported as potential imaging agents for bimodal imaging. Several routes have been explored, including conjugation of CA to macromolecular entities such as dendrimers and polymers, [2][3][4][5][6][7] interaction with proteins, such as human serum albumin (HSA), [8][9][10][11] the incorporation of CA into micelles or liposomes, [12][13][14][15][16] formation of gadolinium(III) or manganese(II) based nanoparticles [17][18][19][20] or via synthesis of large molecules [21][22][23][24] that hold multiple paramagnetic ions in a supramolecular structure.…”

“…Recently, the combination of OI and MRI has garnered substantial interest, and has been promoted to the preclinical phase. 33,35,36,[50][51][52][53][54][55][56][57][58][59][60] In this study, we report on the design and synthesis of NaGdF 4 :Yb 3+ ,Tm 3+ -UCNPs functionalized with Gd-DO3A. Different approaches have been reported on the development of luminescent/MRI bimodal imaging agents, and these are based on organic fluorophores, transition metal complexes or lanthanide ions.…”