Bimetallic PtCu nanoparticles supported on molybdenum disulfide–functionalized graphitic carbon nitride for the detection of carcinoembryonic antigen

Song, Yiju; Qiao, Jingwen; Li, Wenjun; Ma, Chaoyun; Chen, Siyu; Li, Hongling; Hong, Chenglin

doi:10.1007/s00604-020-04498-y

Cited by 11 publications

(12 citation statements)

References 39 publications

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“…In several other types of carcinomas, such as breast cancer, ovarian cancer, pancreatic cancer, and gastrointestinal cancer, CEA often shows elevation in serum level, which indicates its potentiality as being a tumor marker for clinical cancer diagnosis [ 195 , 196 , 197 ]. Therefore, quantitative measurements of CEA in biological fluids such as blood and serum are critical for locating, and understanding the prognosis, staging, and recurrence of multiple cancers [ 197 , 198 , 199 , 200 , 201 ]. For electrochemical immunosensor/aptasensor assays, MNP-based probes which have strong biocompatibility and electrical conductivity are of great interest [ 201 , 202 , 203 , 204 , 205 ].…”

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

“…For electrochemical immunosensor/aptasensor assays, MNP-based probes which have strong biocompatibility and electrical conductivity are of great interest [ 201 , 202 , 203 , 204 , 205 ]. MNPs have superior efficiency as tags or labels for amplifying biomolecular interactions and as the enhancers of electrochemical signals [ 198 , 199 , 200 , 201 , 202 , 203 ]. Depending upon the complexity and necessities, mono/bi/tri-metallic composites are utilized for constructing different types of ECBs with label-free or labeled, sandwich or non-sandwich strategies for CEA immunosensor/aptasensor [ 195 , 196 , 199 , 207 , 210 ].…”

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

“…MNPs have superior efficiency as tags or labels for amplifying biomolecular interactions and as the enhancers of electrochemical signals [ 198 , 199 , 200 , 201 , 202 , 203 ]. Depending upon the complexity and necessities, mono/bi/tri-metallic composites are utilized for constructing different types of ECBs with label-free or labeled, sandwich or non-sandwich strategies for CEA immunosensor/aptasensor [ 195 , 196 , 199 , 207 , 210 ]. In mono-metallic-based ECBs, the primary concern is to enhance electrocatalytic surface area for anchoring biomolecules such as the antibody, and labeling enzymes or conductive dyes or biomolecules for developing labeled immunosensors [ 197 , 201 ].…”

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

“…In bimetallic-based ECBs, synergistic interactions between multiple MNP components might be able to induce significant signal amplification, when compared with mono metal components [ 199 , 215 ]. In addition, the bimetallic counterpart shows enhanced photo-induced charge transfer properties and biocompatibility [ 199 ]. For instance, Song et al constructed an MoS 2 /C 3 N 4 (graphitic) composite supported with bimetallic Pt–Cu nano-dendrimers for visible light-induced amperometric sandwich immunosensing assay for CEA detection [ 199 ].…”

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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With the rise in public health awareness, research on point-of-care testing (POCT) has significantly advanced. Electrochemical biosensors (ECBs) are one of the most promising candidates for the future of POCT due to their quick and accurate response, ease of operation, and cost effectiveness. This review focuses on the use of metal nanoparticles (MNPs) for fabricating ECBs that has a potential to be used for POCT. The field has expanded remarkably from its initial enzymatic and immunosensor-based setups. This review provides a concise categorization of the ECBs to allow for a better understanding of the development process. The influence of structural aspects of MNPs in biocompatibility and effective sensor design has been explored. The advances in MNP-based ECBs for the detection of some of the most prominent cancer biomarkers (carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), Herceptin-2 (HER2), etc.) and small biomolecules (glucose, dopamine, hydrogen peroxide, etc.) have been discussed in detail. Additionally, the novel coronavirus (2019-nCoV) ECBs have been briefly discussed. Beyond that, the limitations and challenges that ECBs face in clinical applications are examined and possible pathways for overcoming these limitations are discussed.

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Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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Graphitic Carbon Nitride‐Based Photocatalysts for Biological Applications

Che

Zhang

Wang

et al. 2021

Advanced Sustainable Systems

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fluorescent feature, which makes it be served as bioimaging and fluorescence sensors. In addition, g-C 3 N 4 can be used as a drug carrier due to its π-π conjugation with the drug. It can thus be seen that g-C 3 N 4 is a 2D material with many functions in one. As a result, with the development of g-C 3 N 4 -based materials in biological fields, it is urgent to provide a comprehensive review of g-C 3 N 4 -based materials for biological applications.Like other applications, biological applications of g-C 3 N 4 -based materials are still limited by the reason of relatively large particles size, high recombination of carriers, and circumscribed visible-light absorption. [13] Therefore, in this review, the advanced synthesis approaches to improve the properties of g-C 3 N 4 -based materials are outlined and the different solutions to different problems of different applications are reported at great length. For example, three kinds of ways to improve the efficiency of photodynamic therapy (PDT) such as improving the near-infrared response of g-C 3 N 4 , [14] increasing oxygen levels in the microenvironment, [15] and reducing the glutathione (GSH) level in tumor cells are talked about. [16] Moreover, the biosafety and toxicity evaluations of g-C 3 N 4 -based materials are also conducted. Last, the challenges and personal opinions of g-C 3 N 4 -based materials in biomedical applications are discussed. It is hoped that this review could provide references and bases for further expanding the applications of g-C 3 N 4 in biomedical areas. Modification MethodsAt present, the photocatalytic performance of g-C 3 N 4 can be enhanced by defects, [17] hydrogen bond engineering, [18] and integrating with other semiconductors to form a heterojunction structure. [19] Defects EngineeringDefects engineering of g-C 3 N 4 includes vacancy defect and crystal defect. Vacancy in g-C 3 N 4 is served as effective capturing sites for photocarriers to promote charge separation and migration. [20] Doping is an impurity defect belonging to a crystal defect. Impurity defects generally do not change the crystal lattice of the original matrix, but will activate due to lattice malformation and provide conditions for the migration of particles.Metal-free graphitic carbon nitride (g-C 3 N 4 ) as a newly emerging nanomaterial has been employed in the biomedical field because of its special optical and electrical characterizations. This review summarizes diverse methods for preparing g-C 3 N 4 -based materials, and discusses contemporary advancements in biosensors, photocatalytic sterilization, photodynamic therapy, drug carrier, and biological imaging. The biosafety and toxicity evaluations of g-C 3 N 4 -based materials are discussed as well. The review ends with an overview and several insights on the challenges and opportunities of g-C 3 N 4 -based nanomaterials in this burgeoning field. This review is expected to provide inspiration for developing future g-C 3 N 4 -based materials for the biomedical applications.

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Electrochemiluminescence biosensor based on molybdenum disulfide-graphene quantum dots nanocomposites and DNA walker signal amplification for DNA detection

et al. 2021

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Bimetallic PtCu nanoparticles supported on molybdenum disulfide–functionalized graphitic carbon nitride for the detection of carcinoembryonic antigen

Cited by 11 publications

References 39 publications

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Graphitic Carbon Nitride‐Based Photocatalysts for Biological Applications

Electrochemiluminescence biosensor based on molybdenum disulfide-graphene quantum dots nanocomposites and DNA walker signal amplification for DNA detection

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