Bimakalim: A Promising K<sub>ATP</sub> Channel Activating Agent

There is considerable evidence that opening the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) is cardioprotective in ischemia-reperfusion. Two prominent questions surround the role of mitoK(ATP) in the cardiomyocyte: How does opening mitoK(ATP) protect? What is the normal physiological role of mitoK(ATP) in the heart? Before these questions can be addressed, it is necessary to agree on the bioenergetic consequences of opening mitoK(ATP), and this distills down to a single question--does opening mitoK(ATP) cause significant uncoupling or not? The evidence strongly indicates that it does not and that reports of uncoupling and inhibition of Ca2+ uptake are the result of using toxic concentrations of K(ATP) channel openers. Thus, opening mitoK(ATP) results in increased K+ flux that is sufficient to change mitochondrial volume but is insufficient to cause significant depolarization of membrane potential. The volume changes, however, have significant bioenergetic consequences for energy coupling in the cell.

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Opening mitochondrial K ATP in the heart - what happens, and what does not happen

Garlid

2000

Basic Research in Cardiology

170

123

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S3/7 Intramitochondrial signaling — Interactions among mitoKATP, PKCε, ROS, and MPT

Garlid

Costa

2008

Biochimica et Biophysica Acta (BBA) - Bioenergetics

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Torsion of the human left ventricle: Experimental analysis and computational modeling

Evangelista

Nardinocchi

Puddu

et al. 2011

Progress in Biophysics and Molecular Biology

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Bimakalim: A Promising K_ATP Channel Activating Agent

Cited by 11 publications

References 56 publications

Opening mitochondrial K ATP in the heart - what happens, and what does not happen

Opening mitochondrial K ATP in the heart - what happens, and what does not happen

S3/7 Intramitochondrial signaling — Interactions among mitoKATP, PKCε, ROS, and MPT

Torsion of the human left ventricle: Experimental analysis and computational modeling

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Bimakalim: A Promising KATP Channel Activating Agent

Cited by 11 publications

References 56 publications

Opening mitochondrial K ATP in the heart - what happens, and what does not happen

Opening mitochondrial K ATP in the heart - what happens, and what does not happen

S3/7 Intramitochondrial signaling — Interactions among mitoKATP, PKCε, ROS, and MPT

Torsion of the human left ventricle: Experimental analysis and computational modeling

Contact Info

Product

Resources

About

Bimakalim: A Promising K_ATP Channel Activating Agent