Bimagrumab to improve recovery after hip fracture in older adults: a multicentre, double-blind, randomised, parallel-group, placebo-controlled, phase 2a/b trial

Hofbauer, Lorenz C.; Witvrouw, Richard; Varga, Zsuzsanna; Shiota, Naofumi; Cremer, Malika; Tankó, László B.; Rooks, Daniel; Auberson, Lixin Zhang; Arkuszewski, Michał; Fretault, Nathalie; Schubert-Tennigkeit, Agnes Annette; Papanicolaou, Dimitris A.; Recknor, Chris

doi:10.1016/s2666-7568(21)00084-2

Cited by 16 publications

(3 citation statements)

References 32 publications

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“…Although electrical muscle stimulation, electrical acupuncture, whole body vibration, and Taichi have been introduced to manage sarcopenia, our pooled analysis showed no promising evidence of these interventions having favorable effects on sarcopenia parameters [ 9 ]. Novel agents such as bimagrumab (human monoclonal antibody targeting activin type 2 receptors) [ 100 ] and MK0733 (selective androgen receptor modulator) [ 36 ] have the potential to improve skeletal muscle mass, but our results show no benefit on muscle function and physical performance. Recent studies suggested that dysfunctions at the neuromuscular junction and within mitochondria may contribute to the deterioration of muscle function [ 101 ].…”

Section: Discussionmentioning

confidence: 79%

Is moderate resistance training adequate for older adults with sarcopenia? A systematic review and network meta-analysis of RCTs

Chen,

Liu

et al. 2023

Eur Rev Aging Phys Act

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Background Resistance training (RT) and nutritional supplementation are recommended for the management of sarcopenia in older adults. However, optimal RT intensity for the treatment of sarcopenia has not been well investigated. Methods This network meta-analysis aims to determine the comparative effectiveness of interventions for sarcopenia, taking RT intensity into consideration. RT intensity was classified into light-to-moderate intensity RT(LMRT), moderate intensity RT(MRT), and moderate-to-vigorous intensity RT(MVRT) based on percentage of one repetition maximum (%1RM) and/or rating of perceived exertion. Results A total of 50 RCTs (N = 4,085) were included after screening 3,485 articles. The results confirmed that RT with or without nutrition was positively associated with improved measures of muscle strength and physical performance. Regarding RT intensity, LMRT only demonstrated positive effects on hand grip (aerobic training + LMRT + nutrition: mean difference [MD] = 2.88; 95% credential intervals [CrI] = 0.43,5.32). MRT provided benefits on improvement in the 30-s chair stand test (repetitions) (MRT: MD = 2.98, 95% CrI = 0.35,5.59), timed up and go test (MRT: MD = -1.74, 95% CrI: = -3.34,-0.56), hand grip (MRT: MD = 2.44; 95% CrI = 0.03,5.70), and leg press (MRT: MD = 8.36; 95% CrI = 1.87,13.4). MVRT also improved chair stand test repetitions (MVRT: MD = 5.64, 95% CrI = 0.14,11.4), gait speed (MVRT + nutrition: MD = 0.21, 95% CrI = 0.003,0.48), appendicular skeletal muscle index (MVRT + nutrition: MD = 0.25, 95% CrI = 0.01,0.5), and leg press (MVRT: MD = 14.7, 95% CrI: 5.96,22.4; MVRT + nutrition: MD = 17.8, 95% CrI: 7.55,28.6). Conclusion MVRT had greater benefits on muscle mass, lower extremity strength, and physical performance compared to MRT. Increasing RT intensity may be recommended for sarcopenic older adults.

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Section: Discussionmentioning

confidence: 79%

Is moderate resistance training adequate for older adults with sarcopenia? A systematic review and network meta-analysis of RCTs

Chen,

Liu

et al. 2023

Eur Rev Aging Phys Act

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“…The remaining intervention studies included three drug trials [41][42][43], two magnetic or neuromuscular stimulation trials [44,45], three trials evaluating different surgical methods [46][47][48], and one trial evaluating in-hospital geriatric treatment [49][50][51]. The longest follow-up was 17 years or until death in one of the interventions evaluating surgical methods [48].…”

Section: Description Of the Interventionsmentioning

confidence: 99%

Evaluation of mobility recovery after hip fracture: a scoping review of randomized controlled studies

Taraldsen,

Polhemus,

Engdal

et al. 2023

Osteoporos Int

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Few older adults regain their pre-fracture mobility after a hip fracture. Intervention studies evaluating effects on gait typically use short clinical tests or in-lab parameters that are often limited to gait speed only. Measurements of mobility in daily life settings exist and should be considered to a greater extent than today. Less than half of hip fracture patients regain their pre-fracture mobility. Mobility recovery is closely linked to health status and quality of life, but there is no comprehensive overview of how gait has been evaluated in intervention studies on hip fracture patients. The purpose was to identify what gait parameters have been used in randomized controlled trials to assess intervention effects on older people’s mobility recovery after hip fracture. This scoping review is a secondary paper that identified relevant peer-reviewed and grey literature from 11 databases. After abstract and full-text screening, 24 papers from the original review and 8 from an updated search and manual screening were included. Records were eligible if they included gait parameters in RCTs on hip fracture patients. We included 32 papers from 29 trials (2754 unique participants). Gait parameters were primary endpoint in six studies only. Gait was predominantly evaluated as short walking, with gait speed being most frequently studied. Only five studies reported gait parameters from wearable sensors. Evidence on mobility improvement after interventions in hip fracture patients is largely limited to gait speed as assessed in a controlled setting. The transition from traditional clinical and in-lab to out-of-lab gait assessment is needed to assess effects of interventions on mobility recovery after hip fracture at higher granularity in all aspects of patients’ lives, so that optimal care pathways can be defined. Supplementary Information The online version contains supplementary material available at 10.1007/s00198-023-06922-4.

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“…As higher ADL levels are associated with higher physical activity levels in older adults (Amaral Gomes et al., 2021), changes in physical activity should be monitored throughout the hospitalization period. Because the ability of patients with hip fractures to stand and walk is temporarily impaired immediately after surgery (Hofbauer et al., 2021), making it difficult to measure physical activity at the time of rehabilitation admission (Pommerich et al., 2023), the relationship between physical activity at the time of rehabilitation admission and ADL at discharge is unclear. An activity monitor, such as an activity tracker using a triaxial accelerometer, can detect human body movements during the free‐living activities as well as walking (Szeto et al., 2023), allowing continuous sampling of physical activity in older adults with residual ADL disabilities after hip fracture surgery.…”

Section: Introductionmentioning

confidence: 99%

Relationship between independence in activities of daily living at discharge and physical activity at admission of older postoperative hip fracture rehabilitation inpatients: A retrospective case‐control study

Shimizu,

Kanai,

Asakawa

2024

Physiotherapy Res Intl

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Background and PurposeHip fractures are associated with a reduction in activities of daily living (ADL) and require long‐term care. The physical activity of patients with hip fractures is temporarily impaired immediately after surgery, causing difficulty in the measurement of physical activities at the time of rehabilitation admission. This study examined the relationship between ADL at discharge and light‐ and moderate‐intensity physical activity at the time of rehabilitation admission by determining a cut‐off value predicting ADL independence.MethodsThis retrospective case control study analyzed 43 postoperative hip fracture patients aged ≥65 years admitting into inpatient rehabilitation. ADL at discharge was assessed using the Functional Independent Measure motor items (FIM‐m). The duration of physical activity at the time of rehabilitation admission was measured using an activity tracker equipped with an accelerometer. Prehospital frailty was evaluated using Clinical Frailty Scale. The relationship between these variables was examined using Spearman's product‐moment correlation coefficient. Differences in physical activity between patients requiring and not requiring assistance with ADLs were examined using the analysis of covariance. A receiver operating characteristic curve of the need for ADL assistance at discharge was constructed from the duration of physical activity.ResultsThe duration of physical activity at the time of rehabilitation admission was related to FIM‐m at discharge. The cut‐off value of the duration of physical activity for predicting the need for ADL assistance at discharge was 135 s, with a sensitivity of 83.3% and specificity of 68.4% (area under the curve: 0.76).DiscussionThe duration of physical activity at the time of rehabilitation admission may be a factor that can quantitatively predict the risk of requiring assistance with ADLs at discharge in older hip fracture patients. The duration of light‐and‐moderate intensity physical activity may be a component of multidisciplinary inpatient rehabilitation to improve patients' ADL.

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Bimagrumab to improve recovery after hip fracture in older adults: a multicentre, double-blind, randomised, parallel-group, placebo-controlled, phase 2a/b trial

Cited by 16 publications

References 32 publications

Is moderate resistance training adequate for older adults with sarcopenia? A systematic review and network meta-analysis of RCTs

Is moderate resistance training adequate for older adults with sarcopenia? A systematic review and network meta-analysis of RCTs

Evaluation of mobility recovery after hip fracture: a scoping review of randomized controlled studies

Relationship between independence in activities of daily living at discharge and physical activity at admission of older postoperative hip fracture rehabilitation inpatients: A retrospective case‐control study

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