Bilirubinate Granules: Main Pathologic Bile Component in Patients With Idiopathic Acute Pancreatitis

Pérez-Martín, G; Gómez-Cerezo, J; Codoceo, Rosa; Olveira, Antonio; Conde, P. Delgado; Garcés, M C; Barbado, F J; Vázquez, J. J.

doi:10.1111/j.1572-0241.1998.00360.x

Cited by 9 publications

(10 citation statements)

References 8 publications

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“…In this study, we compared two different types of trans‐abdominal ultrasonographic technique for the diagnosis of biliary sludge in patients affected by ‘idiopathic’ pancreatitis. This patient selection was based on recent evidence suggesting that this disorder is strongly related to biliary sludge, 11–14 and therefore represents an ‘ideal’ model for the detection of this condition. Moreover, the well‐known conflicting aspects of echographic diagnosis of biliary sludge stimulated our study.…”

Section: Discussionmentioning

confidence: 99%

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Second harmonic imaging improves trans‐abdominal ultrasound detection of biliary sludge in ‘idiopathic’ pancreatitis

Ierardi

Muscatiello

Nacchiero

et al. 2003

Aliment Pharmacol Ther

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SUMMARYBackground: Recently, biliary sludge has been strongly correlated with 'idiopathic pancreatitis'. It is often diagnosed by trans-abdominal ultrasonography, despite the low sensitivity of this investigation. New scanners, using second harmonic imaging, may improve the quality of the echographic picture. Aim: To verify the impact of this methodology on the detection of biliary sludge in patients with 'idiopathic' pancreatitis. Methods: Fifty patients with 'idiopathic' pancreatitis observed over a 18-month period entered the study. Exclusion criteria were gall-bladder stones, polyps, clinical conditions related to biliary sludge development

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Section: Discussionmentioning

confidence: 99%

“…Recent evidence has shown that ‘idiopathic’ pancreatitis, a clinical condition characterized by recurrent episodes of acute pancreatic inflammation without an evident known cause, is associated with biliary sludge in 75–90% of patients when detected by microscopy of bile sediment and/or endoscopic ultrasonography 11–14 …”

Section: Introductionmentioning

confidence: 99%

Second harmonic imaging improves trans‐abdominal ultrasound detection of biliary sludge in ‘idiopathic’ pancreatitis

Ierardi

Muscatiello

Nacchiero

et al. 2003

Aliment Pharmacol Ther

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“…Among the ten included studies, there was one RCT 8 , one cross-sectional study 20 , six prospective cohort studies 4,5,21 -24 and two 9,19 retrospective cohort studies (Table 1). The only RCT 8 compared cholecystectomy with conservative treatment in 85 patients with IAP, with an allocation ratio of 1 : 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Most of the studies scored 3 20,24 , 4 5,21 -23 or 5 4,19 of a maximum of 9 points on the Newcastle-Ottawa Scale. One study 9 scored 6 points and the RCT 8 scored 8 points.…”

Section: Critical Appraisalmentioning

confidence: 99%

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Recurrence of idiopathic acute pancreatitis after cholecystectomy: systematic review and meta-analysis

Umans

Hallensleben

Verdonk

et al. 2019

British Journal of Surgery

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Background Occult biliary disease has been suggested as a frequent underlying cause of idiopathic acute pancreatitis (IAP). Cholecystectomy has been proposed as a strategy to prevent recurrent IAP. The aim of this systematic review was to determine the efficacy of cholecystectomy in reducing the risk of recurrent IAP. Methods PubMed, Embase and Cochrane Library databases were searched systematically for studies including patients with IAP treated by cholecystectomy, with data on recurrence of pancreatitis. Studies published before 1980 or including chronic pancreatitis and case reports were excluded. The primary outcome was recurrence rate. Quality was assessed using the Newcastle–Ottawa Scale. Meta-analyses were undertaken to calculate risk ratios using a random-effects model with the inverse-variance method. Results Overall, ten studies were included, of which nine were used in pooled analyses. The study population consisted of 524 patients with 126 cholecystectomies. Of these 524 patients, 154 (29·4 (95 per cent c.i. 25·5 to 33·3) per cent) had recurrent disease. The recurrence rate was significantly lower after cholecystectomy than after conservative management (14 of 126 (11·1 per cent) versus 140 of 398 (35·2 per cent); risk ratio 0·44, 95 per cent c.i. 0·27 to 0·71). Even in patients in whom IAP was diagnosed after more extensive diagnostic testing, including endoscopic ultrasonography or magnetic resonance cholangiopancreatography, the recurrence rate appeared to be lower after cholecystectomy (4 of 36 (11 per cent) versus 42 of 108 (38·9 per cent); risk ratio 0·41, 0·16 to 1·07). Conclusion Cholecystectomy after an episode of IAP reduces the risk of recurrent pancreatitis. This implies that current diagnostics are insufficient to exclude a biliary cause.

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Incidental giardiasis diagnosed by fine-needle aspiration of a phantom cecal “mass”

Rosenthal

2005

Diagn. Cytopathol.

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Bilirubinate Granules: Main Pathologic Bile Component in Patients With Idiopathic Acute Pancreatitis

Abstract: Bilirubinate granules are the main pathologic component of bile in patients with acute idiopathic pancreatitis. Cholecystectomy is the preferred therapeutic approach.

Cited by 9 publications

References 8 publications

Second harmonic imaging improves trans‐abdominal ultrasound detection of biliary sludge in ‘idiopathic’ pancreatitis

Second harmonic imaging improves trans‐abdominal ultrasound detection of biliary sludge in ‘idiopathic’ pancreatitis

Recurrence of idiopathic acute pancreatitis after cholecystectomy: systematic review and meta-analysis

Incidental giardiasis diagnosed by fine-needle aspiration of a phantom cecal “mass”

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