Bilirubin (Modified Jendrassik and Grof)—Provisional

Gambino, S. Raymond; Golden, Walter R.C.; Smith, A.

doi:10.1016/b978-1-4831-9686-2.50012-2

Cited by 30 publications

(7 citation statements)

References 13 publications

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“…The serum so obtained was used to estimate the biochemical study parameters viz. Alanine transaminase (ALT), Alkaline phosphatase (ALP), Total bilirubin and Albumin which were all estimated spectrophotometrically via commercially available reagent kits based on established methods 9,10,11,12 .…”

Section: Biological Study Parametersmentioning

confidence: 99%

Hepatoprotective Effect of Sarvakalp Kwath Against Carbon Tetrachloride Induced Hepatic Injury in Albino Rats

Yadav¹,

Kumar²

2014

Biomed. Pharmacol. J.

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Modern medicine, even in the modern era, lacks effective medications in its armamentarium which could be useful to treat or prevent hepatic ailments. However, Indian Ayurvedic system claims to have many indigenous plants and herbal preparations which provide therapeutic benefit in the treatment of liver diseases. One of such herbal preparations claiming to be of benefit in liver diseases is Sarvakalp Kwath by Divya Pharmacy, Haridwar. This study was undertaken to explore the hepatoprotective effects of Sarvakalp Kwath in animal model using albino rats. The animals were administered aqueous extract of the preparation in the dose of 120 mg/kg for seven days followed by carbon tetrachloride (CCl 4) challenge. Animals were then sacrificed. Hepatic damage and protection from the damage was assessed by biochemical parameters viz. alanine transaminase, alkaline phosphatase, total bilirubin and albumin as well as histological studies. It was observed that aqueous extract of Sarvakalp Kwath offered significant hepatoprotection as reflected by improvement in all biochemical and histological parameters as compared to saline controls. In conclusion, Sarvakalp Kwath offers significant hepatoprotection as is observed in this study. Further studies are warranted to establish its therapeutic efficacy in humans.

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Section: Biological Study Parametersmentioning

confidence: 99%

Hepatoprotective Effect of Sarvakalp Kwath Against Carbon Tetrachloride Induced Hepatic Injury in Albino Rats

Yadav¹,

Kumar²

2014

Biomed. Pharmacol. J.

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“…Biological tests. The serum total bilirubin was measured by the method of Jendrassik & Grof [6], the cholesterol by Pearson's method [7] and the total protein concentration by the biuret method. Protein electrophoresis was performed on cellulose acetate strips which were scanned after staining with Ponceau S. Alanine aminotransferase (L-alanine: 2-oxoglutarate aminotransferase, ALT, EC 2.6.1.2), aspartate aminotransferase (L-aspartic acid: 2-oxoglutarate aminotransferase, AST, EC 2.6.1. l), alkaline phosphatase (EC 3.1.3.1) and y-glutamul transferase (GGT, EC 2.3.2.2) were performed by methods recommended by the German Society for Clinical Chemistry [8].…”

Section: Quick-testmentioning

confidence: 99%

Multivariate analysis of clinical and biological data in cirrhotic patients: application to prognosis

Ekindjian

Devanlay

Duchassaing

et al. 1981

Eur J Clin Investigation

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One hundred and thirty-one patients underwent clinical and biological investigation with the following determinations performed on the same day; presence or absence of ascites, icterus and/or encephalopathy, coagulation study, biochemical determinations including albumin, transferrin and immunoglobulins immunoassays. The principal component analysis of biological data showed two sets of highly representative and inversely correlated data; one included coagulation tests, albumin and transferrin, and the other included immunoglobulin A/transferrin ratio, immunoglobulin A and total bilirubin. Clinical and biological data were computed using discriminant analysis between dead and survivors. Six parameters were then selected (total bilirubin, encephalopathy, factor V, AST, antithrombin III and transferrin) giving a correct prognosis in 81.6% (31/38) of cases in a test sample. Neither ascites nor immunoglobulins were useful for the estimation of the prognosis.

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“…The total cholesterol levels were estimated by enzymatic colorimetric method [13] , total bilirubin levels were estimated by colorimetric method of Accurex Biomedical Pvt. Ltd [14] , and triglyceride levels were measured by enzymatic colorimetric method [15] . This study was approved by the Ethics Committee of the Nalanda Medical College, Patna, India.…”

Section: Methodsmentioning

confidence: 99%

A Comparative Study of Biliary and Serum Lipid Profiles in Patients of Obstructive jaundice due to stones in common bile duct

Nasar¹

2018

jmscr

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Bilirubin (Modified Jendrassik and Grof)—Provisional

Cited by 30 publications

References 13 publications

Hepatoprotective Effect of Sarvakalp Kwath Against Carbon Tetrachloride Induced Hepatic Injury in Albino Rats

Hepatoprotective Effect of Sarvakalp Kwath Against Carbon Tetrachloride Induced Hepatic Injury in Albino Rats

Multivariate analysis of clinical and biological data in cirrhotic patients: application to prognosis

A Comparative Study of Biliary and Serum Lipid Profiles in Patients of Obstructive jaundice due to stones in common bile duct

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