Bilirubin improves renal function by reversing the endoplasmic reticulum stress and inflammation in the kidneys of type 2 diabetic rats fed high-fat diet

Maleki, Mohammad Hassan; Nadimi, Elham; Vakili, Omid; Tavakoli, Ramin; Taghizadeh, Motahareh; Dehghanian, Amirreza; Bordbar, Hossein; Shafiee, Sayed Mohammad

doi:10.1016/j.cbi.2023.110490

Cited by 7 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the past twenty years, a series of cross-sectional studies have consistently suggested an association between high STB levels and a reduced risk of DKD in patients with diabetes (26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Concurrently, animal studies have been conducted to explore the mechanism whereby STB confers protection against DKD (36,37). However, there have been a few studies with conflicting results, suggesting no relationship between STB level and DKD (22,24), or even positing STB as a risk factor for DKD (23).…”

Section: Discussionmentioning

confidence: 99%

Association between serum total bilirubin and diabetic kidney disease in US diabetic patients

Lv,

Shi,

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundBilirubin has been widely reported to be a protective factor against diabetic kidney disease (DKD) in Asian populations. However, few large-sample analyses have been conducted in American populations. This study aimed to investigate the association between serum total bilirubin (STB) level and DKD in a US diabetic cohort.MethodsThis cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Univariate and multivariate logistic regression analyses were performed to assess the association between STB level and DKD. Three models were conducted to control the potential confounding factors. Subgroup analysis was carried out for further validation.ResultsAmong the 5,355 participants, the median age [interquartile range (IQR)] was 62 [52–71] years; 2,836 (52.96%) were male, and 1,576 (29.43%) were diagnosed with DKD. In the entire cohort, no significant association between STB level and DKD was observed in any logistic regression models (p > 0.05). Subgroup analysis revealed that, in U.S. diabetic males, STB levels > 11.98 µmol/L were associated with a nearly 30% lower risk of DKD than STB levels ≤ 8.55 µmol/L. Additionally, a moderate STB level (8.56–11.98 μmol/L) was found associated with a nearly 25% lower risk of DKD in U.S. diabetic patients over 65 years old.ConclusionThe association of STB level with DKD may depict differences across diverse populations, among which the impact of race, sex, and age requires thorough consideration and relevant inferences should be interpreted cautiously.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between serum total bilirubin and diabetic kidney disease in US diabetic patients

Lv,

Shi,

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…As one of the most serious chronic microvascular complications of diabetes mellitus (DM), Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) [ 1 ]. Studies have shown that DKD occurs in approximately 40% of patients with type 2 diabetes mellitus (T2DM) and 30% of patients with type 1 diabetes mellitus (T1DM) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease

Gong,

Wang,

Wang

et al. 2023

Renal Failure

View full text Add to dashboard Cite

Diabetic kidney disease (DKD) is a primary cause of end-stage renal disease. Proteinuria is a clinical indicator of the different stages of DKD, and podocyte injury is a major cause of proteinuria. Podocyte-specific proteins (PSPs) play important roles in the normal filtration of podocytes. Studies have shown that natural active compounds (NACs) can ameliorate proteinuria; however, the mechanism related to PSPs needs to be explored. In this study, the five stages of DKD related to proteinuria and the functions of PSPs are displayed separately. Mechanisms for ameliorating proteinuria and improving the PSPs of the 15 NACs are summarized. The in vitro and in vivo mechanistic research showed that five compounds, astragaloside IV, ligustrazine, berberine, emodin and resveratrol, exerted renal protective effects via AMPK signaling, icariin and berberine via TLR4 signaling, hirudin and baicalin via MAPK signaling, curcumin and baicalin via NF-κB signaling, and emodin via protein kinase RNA-like endoplasmic reticulum kinase signaling. The 13 PSPs were divided into five categories: actin cytoskeleton, basal domain, apical domain, slit diaphragm, and others. In conclusion, anti-inflammatory effects, anti-oxidative stress, and enhanced autophagy are the main mechanisms underlying the ameliorative effects of NACs. Podocyte apoptosis is mainly related to nephrin and podocin, which are the most studied slit diaphragm PSPs.

show abstract

Targeting apoptosis and unfolded protein response: the impact of β-hydroxybutyrate in clear cell renal cell carcinoma under glucose-deprived conditions

Roohy,

Siri,

Kohansal

et al. 2024

Mol Biol Rep

View full text Add to dashboard Cite

Bilirubin improves renal function by reversing the endoplasmic reticulum stress and inflammation in the kidneys of type 2 diabetic rats fed high-fat diet

Cited by 7 publications

References 47 publications

Association between serum total bilirubin and diabetic kidney disease in US diabetic patients

Association between serum total bilirubin and diabetic kidney disease in US diabetic patients

Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease

Targeting apoptosis and unfolded protein response: the impact of β-hydroxybutyrate in clear cell renal cell carcinoma under glucose-deprived conditions

Contact Info

Product

Resources

About