Bilirubin Conjugation and Biliary Bilirubin Excretion after Intravenous Bilirubin Injection in Dogs.

Bilirubin and bile acids may modulate their own metabolism via regulating uridine diphosphate‐glucuronosyltransferase expression in the rat

“…Previous studies have demonstrated that bilirubin loading in both rats and dogs increased the proportion of conjugated bilirubin. 3,4 This enhancement of conjugation was postulated to be a result of increased UGT activity in the hepatocytes. Increased glucuronidation of bile acids following their infusion in the rat has also been reported.…”