Bilirubin concentration is positively associated with haemoglobin concentration and inversely associated with albumin to creatinine ratio among Indigenous Australians: eGFR Study

Hughes, Jaquelyne T.; Barzi, Federica; Hoy, Wendy E.; Jones, Graham; Rathnayake, Geetha; Majoni, Sandawana William; Thomas, Mark; Sinha, Ashim; Cass, Alan; MacIsaac, Richard J; O’Dea, Kerin; Maple-Brown, Louise

doi:10.1016/j.clinbiochem.2017.08.011

Cited by 9 publications

(16 citation statements)

References 37 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that serum bilirubin concentrations are positively correlated with hemoglobin concentration and inversely correlated with ACR among Indigenous Australians [27]. In the current study, we also found that serum bilirubin levels were significantly positively correlated with hemoglobin and albumin levels, and insignificantly inversely correlated with ACR in anti-NMDAR encephalitis.…”

Section: Discussionsupporting

confidence: 74%

Serum Bilirubin and Albumin in Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Shu

Chen

et al. 2018

Neuroimmunomodulation

View full text Add to dashboard Cite

Background and Objective: Low serum levels of bilirubin and albumin are associated with multiple autoimmune diseases, but their role in anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown. Methods: Serum bilirubin and albumin levels were evaluated in 60 patients with anti-NMDAR encephalitis, 50 cryptococcal encephalitis, and 145 healthy controls (CTLs). Of the 60 anti-NMDAR encephalitis patients, 30 had a follow-up evaluation at 3 months after admission. Results: Serum bilirubin and albumin levels were both significantly lower in anti-NMDAR encephalitis than in CTLs, and serum bilirubin levels were significantly lower in anti-NMDAR encephalitis than in cryptococcal encephalitis. Serum bilirubin levels were significantly lower in patients with psychiatric symptoms, with severe impairment, and with limited responses to treatment than those without psychiatric symptoms, with mild impairment, and with favorable responses to treatment, respectively. A follow-up evaluation of 30 patients revealed that the modified Rankin Scale scores were significantly decreased after treatment. Serum bilirubin significantly associated with serum albumin, and plasma hemoglobin. Conclusions: Our results revealed for the first time an association between the serum levels of bilirubin in the anti-NMDAR encephalitis. Further studies investigating the role of bilirubin and albumin in anti-NMDAR encephalitis are required.

show abstract

Section: Discussionsupporting

confidence: 74%

Serum Bilirubin and Albumin in Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Shu

Chen

et al. 2018

Neuroimmunomodulation

View full text Add to dashboard Cite

show abstract

“…J.T. Hughes et al [14] found that serum TB concentration was positively related with TC in 594 Indigenous Australians. Recent reports found the use of statins have a low negative effect on TB concentration [23].…”

Section: Discussionmentioning

confidence: 99%

“…Opposite opinion was also existed. A cross-sectional analysis of 594 Indigenous Australians reported a positive correlation between TB and TC [14]. However, their research population was too small to be demographically representative.…”

Section: Introductionmentioning

confidence: 98%

Relationships between serum total bilirubin levels and hypercholesterolemia in Chinese men and women.

Zhang

Huang

Fan

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective Bilirubin, an antioxidant, is reported to relate with metabolic syndrome and cardiovascular diseases. The current study is to assess the relationship between total bilirubin (TB) and hypercholesterolemia in the Chinese population. Methods This cross-sectional study involved 48971 males and 31327 females who were in good health. Physical examinations and laboratory tests including TB and total cholesterol (TC) were performed. Subjects were divided into the following groups according to age: subjects younger than 30 years, subjects aged between 30 to 60 years and subjects older than 60 years. Binary logistic regression models examining factors independently related to TB was performed for males and females in different age groups. Results TB was negatively related to most parameters in males and females, such as body mass index (BMI), blood urea nitrogen (BUN), TC, triglycerides (TG), low-density lipoprotein (LDL) and glucose (G). The incidence of high TC was higher in females than in males and decreased with the increasing of TB in both genders. People older than 30 years demonstrated a similar trend. When there were no other covariates, TB appeared to be an important risk factor for high TC for men and women. However, this relationship disappeared when other covariates were added in the binary logistic regression models. Similar results also existed in men younger than 60 years and women younger than 30 years. Conclusions Our findings implied that serum TB concentration was not an independent risk predictor for hypercholesterolemia. TB was thought to be a covariate factor in the development of dyslipidemia.

show abstract

“…Some recent studies have shown a possible association of elevated concentrations of white blood cells with kidney function decline [5,6] and others have shown that the neutrophil/lymphocyte ratio, a marker of systemic in ammation, may be associated with poor renal outcomes [7,8]. Furthermore, there is also emerging evidence of an association of abnormal liver function tests with decline in eGFR and increasing albuminuria [9] The eGFR study was a longitudinal study of 654 Indigenous Australian adults from more than 20 sites in urban, regional, and remote Australian regions known to have high incidence of dialysis requiring ESKD, and participants were selected across ve strata of health, diabetes status, and kidney function [10][11][12]. This study con rmed the accuracy of the CKD-EPI equation in estimating GFR in Indigenous Australians [12].…”

Section: Introductionmentioning

confidence: 99%

“…In a longitudinal follow-up, progression of CKD occurred rapidly, with loss of kidney function at approximately three times higher rate than expected through healthy ageing [13,14]. Predictors of progression of CKD included elevated baseline urine albumin/creatinine ratio (UACR) and C-reactive protein (CRP) concentrations [9,14,15]. The in ammatory marker, soluble tumour necrosis factor receptor 1 (sTNFR1), was also associated with CKD progression, where this outcome was independent of albuminuria and eGFR in participants with diabetes [4].…”

Section: Introductionmentioning

confidence: 99%

Association of Baseline Concentrations of Liver Function Tests and Full Blood Count Indices with Annual eGFR Decline and Renal Outcomes in Aboriginal and Torres Strait Islander People: The eGFR Follow- Up Study

Majoni

Barzi

Hoy

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Determination of risks for progression in chronic kidney disease (CKD) would improve strategies to reduce progression to ESKD. The eGFR study recruited and followed a cohort of adult Aboriginal and Torres Strait Islander people (Indigenous Australians) from Northern Queensland, Northern Territory and Western Australia, with the aim to address the heavy CKD burden experienced within these communities.Methods: Using data from the eGFR study, we explored the association of baseline liver function tests (LFTs) (alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), bilirubin and albumin) and full blood count (FBC) indices (white blood cell and red blood cell counts and haemoglobin) with annual eGFR decline and renal outcomes (first of 30% decline in eGFR with a follow-up eGFR <60 mL/min/1.73 m2, initiation of renal replacement therapy, or renal death). Comparisons of baseline variables across eGFR categories were calculated using analysis of variance and logistic regression as appropriate. Linear and multivariable regression models were used to estimate the annual change in eGFR for changes in FBC indices and LFTs. Cox proportional hazard models were used to estimate the hazard ratio for developing renal outcome for changes in baseline FBC indices and LFTs.Results: Of 547 participants, 540 had at least one baseline measure of LFTs and FBC indices. The mean age was 46.1 (14.7) years and 63.6% were female. The median follow-up was 3.1 (IQR 2.8-3.6) years. Annual decline in eGFR was associated with low serum albumin (p<0.001) and haemoglobin (p=0.007). After adjustment for age, gender, urine albumin/creatinine ratio, diabetes and cardiometabolic markers, low serum albumin (p<0.001), haemoglobin (p=0.012) and bilirubin (p=0.011) were associated with annual decline in eGFRRenal outcomes were inversely associated with serum albumin (p<0.001), bilirubin (p=0.012) and haemoglobin (p<0.001) and directly with GGT (p=0.007) and ALP (p<0.001). Other FBC indices and LFTs were not associated with annual decline in eGFR or renal outcomes.Conclusions: GGT, ALP, bilirubin, albumin and haemoglobin independently associate with renal outcomes. Contrary to findings from other studies, no association was found between renal outcomes and other FBC indices. These findings may help focus strategies to prevent disease progression in this high-risk population.

show abstract

Bilirubin concentration is positively associated with haemoglobin concentration and inversely associated with albumin to creatinine ratio among Indigenous Australians: eGFR Study

Abstract: Serum bilirubin concentrations were positively associated with Hb and total cholesterol, and inversely associated with ACR. Further research to determine reasons explaining lower bilirubin concentrations among Aboriginal compared with TSI participants are needed.

Cited by 9 publications

References 37 publications

Serum Bilirubin and Albumin in Anti-<b><i>N</i></b>-Methyl-D-Aspartate Receptor Encephalitis

Serum Bilirubin and Albumin in Anti-<b><i>N</i></b>-Methyl-D-Aspartate Receptor Encephalitis

Relationships between serum total bilirubin levels and hypercholesterolemia in Chinese men and women.

Association of Baseline Concentrations of Liver Function Tests and Full Blood Count Indices with Annual eGFR Decline and Renal Outcomes in Aboriginal and Torres Strait Islander People: The eGFR Follow- Up Study

Contact Info

Product

Resources

About