1991
DOI: 10.1159/000243412
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Bilirubin Accumulation by the Rabbit Choroid Plexus in vitro

Abstract: The postnatal development of bilirubin accumulation by the choroid plexus was studied in vitro. Choroid plexus of the fourth and lateral cerebral ventricles from adult or 1-, 7-, 15- or 21-day-old rabbits were incubated in a potassium-rich medium with 70 nmol/l of 3H-bilirubin for 5 min. The tissue/medium (T/M) ratio for 3H-bilirubin was considerable even 1 day post partum and increased during the next 2–3 weeks of life. In adults the 3H-bilirubin T/M ratio returned to the leve… Show more

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Cited by 5 publications
(2 citation statements)
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“…CHOROID PLEXUS EPITHELIUM Besides characteristic OAT-substrates, the choroid plexus has been shown to remove also larger and more lipophilic (i.e., more "bulky") organic anions from CSF such as iodipamide (Barany, 1973a,b), bile salts (Barany, 1974), and bilirubin (Jakobson, 1991). Choroid plexus transport of these organic anions was less sensitive to probenecid and not inhibitable by p-aminohippurate or urographic radiocontrast agents, but sensitive to a variety of organic compounds normally excreted into bile including bile salts, sulfobromophthalein (BSP) and cholegraphic contrast agents (Barany, 1973b).…”
Section: Polar Distribution Of Two Liver-like Organic Anion Transportmentioning
confidence: 99%
“…CHOROID PLEXUS EPITHELIUM Besides characteristic OAT-substrates, the choroid plexus has been shown to remove also larger and more lipophilic (i.e., more "bulky") organic anions from CSF such as iodipamide (Barany, 1973a,b), bile salts (Barany, 1974), and bilirubin (Jakobson, 1991). Choroid plexus transport of these organic anions was less sensitive to probenecid and not inhibitable by p-aminohippurate or urographic radiocontrast agents, but sensitive to a variety of organic compounds normally excreted into bile including bile salts, sulfobromophthalein (BSP) and cholegraphic contrast agents (Barany, 1973b).…”
Section: Polar Distribution Of Two Liver-like Organic Anion Transportmentioning
confidence: 99%
“…No study has specifically investigated the involvement of MRP1 in UCB transport across the BCSFB. A considerable uptake of UCB by isolated rabbit CP has been described, which is inhibited by iodipamide, a substrate of organic anion transport systems (Jakobson, 1991). Which OATP or other transport proteins located at the brain-facing membranes of the BCSFB are involved in the clearance of UCB from the CNS remains an open question.…”
Section: Bilirubin Interactions With Metabolic/transport Processes Atmentioning
confidence: 99%