Biliary reflux-gastritis: etiology, pathogenesis and modern principles of treatment

Tel’nykh, Yuri V.; Abgadzhava, E. Z.; Kon’kov, M. Yu.

doi:10.18821/0023-2149-2016-94-6-454-457

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Retrospective analysis showed that the detection rate of BRG in the Chinese population is 11.3% and that the rate is significantly higher among women (4). The etiology and pathogenesis of BRG are complex and involve many mechanisms, such as gastrointestinal motility and neuroendocrine and pathological changes (5). The condition reoccurs easily, often lingers, and is difficult to fully heal.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese patent medicine for bile reflux gastritis: a systematic review and network meta-analysis

He¹,

Wang²,

Liu³

et al. 2021

Ann Palliat Med

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Background: Traditional Chinese Patent Medicine (TCPM) is widely used in the treatment of bile reflux gastritis (BRG). However, there is still a lack of research evaluating the efficacy of specific drugs. Thus, we conducted a reticulated meta-analysis to compare the efficacy of TCPMs in the treatment of BRG. Methods: We searched the China National Knowledge Infrastructure (CNKI), PubMed, Web of Science, and the WanFang, and Embase databases, as of February 2021, for publications on the treatment of BRG with Chinese patent medicines in randomized controlled trials (RCTs). The main outcome indicator was the effective rate. The secondary outcome indicators were recurrence rate, traditional Chinese medicine (TCM) symptom score, and gastroscopic mucosal score. The Cochrane bias risk assessment tool was used to evaluate the research quality, and RevMan software (5.2) and Stata software (15.0) were used for the network meta- analysis.Results: A total of 24 studies were included in the meta-analysis. In total, 2,417 patients were included in the meta-analysis, comprising 1,222 patients in the treatment group and 1,195 patients in the control group.The results of the network meta-analysis showed that Weiyankang capsules combined with hydrotalcite had the best effect in the treatment of bile reflux among the 14 interventions. Among the 5 studies that reported recurrence rates, patients administered Shugan Hewei pills had the lowest recurrence rate. A direct comparison showed that TCPMs or TCPMs combined with Western medicines had certain advantages in improving the scores of traditional Chinese medicine symptoms and mucosal scores under gastroscopy.

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Section: Introductionmentioning

confidence: 99%

Traditional Chinese patent medicine for bile reflux gastritis: a systematic review and network meta-analysis

He¹,

Wang²,

Liu³

et al. 2021

Ann Palliat Med

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Specific Features of Duodenogastric Reflux Clinical Course in Patients With Chronic Gastritis

Hutsalenko

2019

VPBM

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Biliary refl ux gastritis: features of pathogenesis, diagnostics and treatment

Sheptulin,

Storonova,

Pavlov

et al. 2023

jour

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The article discusses the controversial terminology of biliary refl ux gastritis and the factors predisposing to its occurrence. Pathogenesis of this disease includes 2 main components: disorders of motility of the stomach and duodenum, leading to duodeno-gastric refl ux, and direct damaging eff ect of hydrophobic bile acids and lysolecithin on the protective barrier of the stomach mucosa. Clinical picture of biliary refl ux gastritis is nonspecifi c and most often corresponds to dyspepsia syndrome. Esophagogastroduodenoscopy with biopsy and subsequent histological examination, 24-hour pH-metry of the stomach, monitoring of bilirubin level in gastric contents are used in diagnostics of this disease. Treatment of biliary refl ux gastritis includes prescription of ursodeoxycholic acid, prokinetics, antacids, proton pump inhibitors, cytoprotectors. Given the insuffi cient study and controversial coverage of many aspects of biliary refl ux gastritis, this problem requires further research.

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Biliary reflux-gastritis: etiology, pathogenesis and modern principles of treatment

Cited by 3 publications

References 8 publications

Traditional Chinese patent medicine for bile reflux gastritis: a systematic review and network meta-analysis

Traditional Chinese patent medicine for bile reflux gastritis: a systematic review and network meta-analysis

Specific Features of Duodenogastric Reflux Clinical Course in Patients With Chronic Gastritis

Biliary refl ux gastritis: features of pathogenesis, diagnostics and treatment

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