Biliary Drainage Improves the Predictive Value of Modified Glasgow Prognostic Scores in Inoperable Pancreatic Cancer

Abstract

ObjectiveTo assess the influence of biliary drainage to cholangitis on modified Glasgow Prognostic Score (mGPS) in patients with pancreatic cancer. MethodsmGPS was calculated before and after biliary drainage in 47 consecutive patients with inoperable pancreatic cancer who were receiving chemotherapy. Biliary drainage was indicated for malignant obstructive jaundice that prevented the administration of chemotherapy. To elucidate mGPS values, serum levels of CRP and albumin were measured at the time of diagnosis (before biliary drainage). Overall survival was evaluated and risk factors, which contribute to overall survival, were examined.

Prognostic Significance of the Modified Glasgow Prognostic Score in Patients With Pancreatic Cancer: A Meta-Analysis

“…Finally, 26 studies were included in this meta-analysis. 15 - 40 The literature selection process is shown in Figure 1 . In the included studies, one study 18 recruited 2 independent cohorts of patients receiving chemotherapy or surgical resection, and the HRs and 95% CIs were separately given for these 2 cohorts.…”

“…A total of 24 cohort studies consisting of 4651 patients [15][16][17][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][36][37][38][39][40] reported the HRs and 95% CIs for the relationship between mGPS and OS in pancreatic cancer. A random-effects model was applied due to significant heterogeneity (I 2 ¼ 68.1%, P < .001, Table 2; Figure 2A).…”

The Prognostic Value of Modified Glasgow Prognostic Score in Pancreatic Cancer: A Meta-analysis

“…Ultimately, 20 studies [8,[15][16][17][18][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] including 6512 patients were enrolled in this meta-analysis after excluding ineligible studies.…”

“…2. In 12 studies that used mGPS=1 as the cutoff value, the subgroup analyses based on the region showed that eastern patients with higher mGPS had a decline of OS (HR=1.60, 95% CI=1 24. 2.06, P<0.0001), but not in western patients (HR=1.34, 95% CI=0.80-2.26, P=0.268; Fig.…”

The Prognostic Value of Modified Glasgow Prognostic Score in Pancreatic Cancer: A Meta-analysis

“…1, the literature search process was summarized in the ow diagram according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) [23]. Ultimately, 20 studies [8,[15][16][17][18][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] including 6512 patients were enrolled in this meta-analysis after excluding ineligible studies.…”